WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice

Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis

(2018) Eric J. Lawitz et al.   Clinical Gastroenterology and Hepatology

Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis

(2018) Maria Apostolopoulou et al.   DIABETES CARE

Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents

(2018) Leigh Goedeke et al.   HEPATOLOGY

Lipotoxicity and the gut-liver axis in NASH pathogenesis

(2018) Fabio Marra et al.   JOURNAL OF HEPATOLOGY

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

(2018) James S.V. Lally et al.   Cell Metabolism

GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease

(2018) Rohit Loomba et al.   GASTROENTEROLOGY

q2-longitudinal: Longitudinal and Paired-Sample Analyses of Microbiome Data

(2018) Nicholas A. Bokulich et al.   mSystems

Comprehensive Metabolomic and Lipidomic Profiling of Human Kidney Tissue: A Platform Comparison

(2017) Patrick Leuthold et al.   JOURNAL OF PROTEOME RESEARCH

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis

(2017) Anna M. Diehl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus

(2017) Cristina Llorente et al.   Nature Communications

Design, synthesis and biological evaluation of dihydroquinoxalinone derivatives as BRD4 inhibitors

(2016) Yifei Yang et al.   BIOORGANIC CHEMISTRY

Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation

(2016) Lirui Wang et al.   Cell Host & Microbe

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

(2016) Jérôme Boursier et al.   HEPATOLOGY

Plasma Lipidomics Investigation of Hemodialysis Effects by Using Liquid Chromatography–Mass Spectrometry

(2016) Lichao Wang et al.   JOURNAL OF PROTEOME RESEARCH

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

Nonalcoholic steatohepatitis (NASH) drugs market

(2016) Sorcha Cassidy et al.   NATURE REVIEWS DRUG DISCOVERY

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

(2016) Giovanni Musso et al.   NATURE REVIEWS DRUG DISCOVERY

The role of the gut microbiota in NAFLD

(2016) Christopher Leung et al.   Nature Reviews Gastroenterology & Hepatology

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

(2016) Geraldine Harriman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase

(2015) Daniel W. Kung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice

(2015) Magdalena Mazagova et al.   FASEB JOURNAL

Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer

(2015) Jia Wei et al.   NATURE

Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

(2014) David A. Griffith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in the Development of Acetyl-CoA Carboxylase (ACC) Inhibitors for the Treatment of Metabolic Disease

(2014) Matthew P. Bourbeau et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis

(2012) David Berry et al.   ISME Journal

High-fat, high-fructose diet induces hepatic iron overload via a hepcidin-independent mechanism prior to the onset of liver steatosis and insulin resistance in mice

(2012) Hiroyuki Tsuchiya et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Global metabolic profiling of animal and human tissues via UPLC-MS

(2012) Elizabeth J Want et al.   Nature Protocols

Fatty acid metabolism: target for metabolic syndrome

(2008) Salih J. Wakil et al.   JOURNAL OF LIPID RESEARCH