Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

Synthesis and biological evaluation of new long-chain squaramides as anti-chagasic agents in the BALB/c mouse model

(2019) Rubén Martín-Escolano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cytotoxicity of acetylcholinesterase reactivators evaluated in vitro and its relation to their structure

(2018) Lubica Muckova et al.   DRUG AND CHEMICAL TOXICOLOGY

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease

(2018) V. Hepnarova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in the asymmetric catalytic synthesis of chiral 3-hydroxy and 3-aminooxindoles and derivatives: Medicinally relevant compounds

(2018) Pedro Brandão et al.   TETRAHEDRON

Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds

(2018) Ewgenij Proschak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Squaramide catalyzed α-chiral amine synthesis

(2018) Seda Karahan et al.   TETRAHEDRON LETTERS

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

The pharmacology of tacrine at N -methyl- d -aspartate receptors

(2017) Martin Horak et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Novel squaramides with in vitro liver stage antiplasmodial activity

(2016) Carlos J.A. Ribeiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Defining the earliest pathological changes of Alzheimer's disease

(2016) James C. Vickers et al.   Current Alzheimer Research

Effective anti-leishmanial activity of minimalist squaramide-based compounds

(2016) Clotilde Marín et al.   EXPERIMENTAL PARASITOLOGY

Bifunctional Amine-Squaramides: Powerful Hydrogen-Bonding Organocatalysts for Asymmetric Domino/Cascade Reactions

(2015) Pankaj Chauhan et al.   ADVANCED SYNTHESIS & CATALYSIS

Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

(2015) Eugenie Nepovimova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Design, synthesis and in vitro testing of 7-methoxytacrine-amantadine analogues: a novel cholinesterase inhibitors for the treatment of Alzheimer’s disease

(2015) Katarina Spilovska et al.   MEDICINAL CHEMISTRY RESEARCH

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects

(2014) Eugenie Nepovimova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

(2013) Florian Nachon et al.   BIOCHEMICAL JOURNAL

Neuroprotective Effects of Bis(7)-tacrine in a Rat Model of Pressure-Induced Retinal Ischemia

(2013) Jing-bo Li et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

A Resurrection of 7-MEOTA: A Comparison with Tacrine

(2013) Ondrej Soukup et al.   Current Alzheimer Research

Structure-Based Search for New Inhibitors of Cholinesterases

(2013) Marek Bajda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study

(2013) Vendula Sepsova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer’s Disease Treatment — Synthesis, Biological Evaluation and Molecular Modeling Studies

(2013) Katarina Spilovska et al.   MOLECULES

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metal ions, Alzheimer's disease and chelation therapy

(2011) Ana Budimir   ACTA PHARMACEUTICA

The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

(2011) Jonathan Z. Long et al.   CHEMICAL REVIEWS

Squaramides: physical properties, synthesis and applications

(2011) R. Ian Storer et al.   CHEMICAL SOCIETY REVIEWS

Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease

(2011) Rafael León et al.   MEDICINAL RESEARCH REVIEWS

Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment

(2011) A. Minarini et al.   NEUROPHARMACOLOGY

Colorimetric dipstick for assay of organophosphate pesticides and nerve agents represented by paraoxon, sarin and VX

(2010) Miroslav Pohanka et al.   TALANTA

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia

(2008) Yuming Zhao et al.   NEUROSCIENCE LETTERS

Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators

(2008) Miroslav Pohanka et al.   TALANTA

Promising anti-Alzheimer’s dimer bis(7)-tacrine reduces β-amyloid generation by directly inhibiting BACE-1 activity

(2007) Hongjun Fu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS