Screening of Chemical Libraries Using a Yeast Model of Retinal Disease

Ligand channel in pharmacologically stabilized rhodopsin

(2018) Daniel Mattle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy

(2018) Dimitra Athanasiou et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Coupling of Human Rhodopsin to a Yeast Signaling Pathway Enables Characterization of Mutations Associated with Retinal Disease

(2018) Benjamin M. Scott et al.   GENETICS

The role of the ER stress-response protein PERK in rhodopsin retinitis pigmentosa

(2017) Dimitra Athanasiou et al.   HUMAN MOLECULAR GENETICS

Pharmacological chaperone approaches for rescuing GPCR mutants: Current state, challenges, and screening strategies

(2017) Pieter Beerepoot et al.   PHARMACOLOGICAL RESEARCH

Receptor antagonism/agonism can be uncoupled from pharmacoperone activity

(2016) Jo Ann Janovick et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Pharmacological approaches to retinitis pigmentosa: A laboratory perspective

(2015) Viviana Guadagni et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Assay strategies for identification of therapeutic leads that target protein trafficking

(2015) P. Michael Conn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Highly Characterized Yeast Toolkit for Modular, Multipart Assembly

(2015) Michael E. Lee et al.   ACS Synthetic Biology

A Phenotypic High Throughput Screening Assay for the Identification of Pharmacoperones for the Gonadotropin Releasing Hormone Receptor

(2014) P. Michael Conn et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Inherent Instability of the Retinitis Pigmentosa P23H Mutant Opsin

(2014) Yuanyuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Challenges using diagnostic next-generation sequencing in the clinical environment for inherited retinal disorders

(2014) Wayne IL Davies   Personalized Medicine

Retinitis Pigmentosa Mutants Provide Insight into the Role of the N-terminal Cap in Rhodopsin Folding, Structure, and Function

(2013) Chikwado A. Opefi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Throughput Screening for Growth Inhibitors Using a Yeast Model of Familial Paraganglioma

(2013) Irina Bancos et al.   PLoS One

Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates  -Synuclein Toxicity in Neurons

(2013) D. F. Tardiff et al.   SCIENCE

Treatment With 9-cisβ-Carotene–Rich Powder in Patients With Retinitis Pigmentosa

(2013) Ygal Rotenstreich et al.   JAMA Ophthalmology

Rhodopsin Mutant P23H Destabilizes Rod Photoreceptor Disk Membranes

(2012) Mohammad Haeri et al.   PLoS One

Rhodopsin Gene Expression Determines Rod Outer Segment Size and Rod Cell Resistance to a Dominant-Negative Neurodegeneration Mutant

(2012) Brandee A. Price et al.   PLoS One

Clinical Trial of Lutein in Patients With Retinitis Pigmentosa Receiving Vitamin A

(2010)   ARCHIVES OF OPHTHALMOLOGY

A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics

(2010) Giampiero Porcu et al.   Molecular Cancer

Pharmacological manipulation of gain-of-function and dominant-negative mechanisms in rhodopsin retinitis pigmentosa

(2008) Hugo F. Mendes et al.   HUMAN MOLECULAR GENETICS

Yeast-Based Fluorescence Reporter Assay of G Protein-coupled Receptor Signalling for Flow Cytometric Screening: FAR1-Disruption Recovers Loss of Episomal Plasmid Caused by Signalling in Yeast

(2008) J. Ishii et al.   JOURNAL OF BIOCHEMISTRY