Tracing IgE-Producing Cells in Allergic Patients

Allergen-Specific Antibodies Regulate Secondary Allergen-Specific Immune Responses

(2019) Julia Eckl-Dorna et al.   Frontiers in Immunology

Human BCR analysis of single-sorted, putative IgE+ memory B cells in food allergy

(2019) Rodrigo Jiménez-Saiz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Non-classical B Cell Memory of Allergic IgE Responses

(2019) Sean P. Saunders et al.   Frontiers in Immunology

IgE-expressing memory B cells and plasmablasts are increased in blood of children with asthma, food allergy, and atopic dermatitis

(2018) J. J. Heeringa et al.   ALLERGY

Mast cells and basophils in allergic inflammation

(2018) Masato Kubo   CURRENT OPINION IN IMMUNOLOGY

Immunological memories of the bone marrow

(2018) Hyun-Dong Chang et al.   IMMUNOLOGICAL REVIEWS

Human mast cells and basophils-How are they similar how are they different?

(2018) Gilda Varricchi et al.   IMMUNOLOGICAL REVIEWS

Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood

(2018) Elena Blanco et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Approaches to target IgE antibodies in allergic diseases

(2018) Bianca Balbino et al.   PHARMACOLOGY & THERAPEUTICS

Anti-IgE therapy for IgE-mediated allergic diseases: from neutralizing IgE antibodies to eliminating IgE+ B cells

(2018) Jiayun Hu et al.   Clinical and Translational Allergy

Genetic restriction of antigen-presentation dictates allergic sensitization and disease in humanized mice

(2018) Alina Neunkirchner et al.   EBioMedicine

Dupilumab does not affect correlates of vaccine-induced immunity: a randomized, placebo-controlled trial in adults with moderate-to-severe atopic dermatitis

(2018) Andrew Blauvelt et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

IgE-class–specific immunosuppression in offspring by administration of anti-IgE to pregnant mice

(2018) Hideaki Morita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes

(2018) Derek Croote et al.   SCIENCE

CD23 surface density on B cells is associated with IgE levels and determines IgE-facilitated allergen uptake, as well as activation of allergen-specific T cells

(2017) Regina Selb et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A novel recycling mechanism of native IgE-antigen complexes in human B cells facilitates transfer of antigen to dendritic cells for antigen presentation

(2017) Paul Engeroff et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Extracorporeal IgE Immunoadsorption in Allergic Asthma: Safety and Efficacy

(2017) Christian Lupinek et al.   EBioMedicine

Pharmacokinetics, Pharmacodynamics, and Safety of MEDI4212, an Anti-IgE Monoclonal Antibody, in Subjects with Atopy: A Phase I Study

(2016) Eric Sheldon et al.   ADVANCES IN THERAPY

Ontogeny of human IgE-expressing B cells and plasma cells

(2016) F. Ramadani et al.   ALLERGY

CTLA4Fcε, a novel soluble fusion protein that binds B7 molecules and the IgE receptors, and reduces humanin vitrosoluble CD23 production and lymphocyte proliferation

(2016) Daniel Perez-Witzke et al.   IMMUNOLOGY

Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis

(2016) Claus Bachert et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Frequent occurrence of T cell–mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments

(2016) Raffaela Campana et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Panimmunoglobulin and IgE-selective extracorporeal immunoadsorption in patients with severe atopic dermatitis

(2016) Kristian Reich et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human B-cell isotype switching origins of IgE

(2016) Timothy J. Looney et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A randomized trial of quilizumab in adults with refractory chronic spontaneous urticaria

(2016) Jeffrey M. Harris et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses

(2016) Gail M. Gauvreau et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgE-mediated enhancement of CD4+ T cell responses requires antigen presentation by CD8α− conventional dendritic cells

(2016) Zhoujie Ding et al.   Scientific Reports

Poor association of allergen-specific antibody, T- and B-cell responses revealed with recombinant allergens and a CFSE dilution-based assay

(2015) J. Eckl-Dorna et al.   ALLERGY

IgE+ B cells are scarce, but allergen-specific B cells with a memory phenotype circulate in patients with allergic rhinitis

(2015) K. J. Wong et al.   ALLERGY

Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells

(2015) Andrew C Nyborg et al.   Cellular & Molecular Immunology

Genetics of allergy and allergic sensitization: common variants, rare mutations

(2015) Klaus Bønnelykke et al.   CURRENT OPINION IN IMMUNOLOGY

Mouse and human FcR effector functions

(2015) Pierre Bruhns et al.   IMMUNOLOGICAL REVIEWS

A novel, nonanaphylactogenic, bispecific IgE-CD3 antibody eliminates IgE+ B cells

(2015) Oktay Kirak et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Targeting Mast Cells and Basophils with Anti-FcεRIα Fab-Conjugated Celastrol-Loaded Micelles Suppresses Allergic Inflammation

(2015) Xia Peng et al.   Journal of Biomedical Nanotechnology

Effects of Nasal Corticosteroids on Boosts of Systemic Allergen-Specific IgE Production Induced by Nasal Allergen Exposure

(2015) Cornelia Egger et al.   PLoS One

Correlation between Skin-prick Testing, Individual Specific IgE Tests, and a Multiallergen IgE Assay for Allergy Detection in Patients with Chronic Rhinitis

(2014) Jae Hoon Cho et al.   American Journal of Rhinology & Allergy

Targeting IgE production in mice and humans

(2014) Lawren C Wu et al.   CURRENT OPINION IN IMMUNOLOGY

Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells

(2014) Alexander Eggel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human IgE+ B cells are derived from T cell–dependent and T cell–independent pathways

(2014) Magdalena A. Berkowska et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin–basophil axis

(2014) Mario Noti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Microarrayed dog, cat, and horse allergens show weak correlation between allergen-specific IgE and IgG responses⋆

(2014) Mirela Curin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Novel B Cell-Mediated Transport of IgE-Immune Complexes to the Follicle of the Spleen

(2014) F. Hjelm et al.   JOURNAL OF IMMUNOLOGY

Tissue Distribution and Dependence of Responsiveness of Human Antigen-Specific Memory B Cells

(2014) C. Giesecke et al.   JOURNAL OF IMMUNOLOGY

A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma

(2014) E Suzanne Cohen et al.   mAbs

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

(2014) Lisa A. Beck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production

(2014) G. M. Gauvreau et al.   Science Translational Medicine

Omalizumab in Asthma: An Update on Recent Developments

(2014) Marc Humbert et al.   Journal of Allergy and Clinical Immunology-In Practice

What Is the Source of Serum Allergen-Specific IgE?

(2013) Julia Eckl-Dorna et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Technical issues: flow cytometry and rare event analysis

(2013) B. D. Hedley et al.   International Journal of Laboratory Hematology

The distinctive germinal center phase of IgE + B lymphocytes limits their contribution to the classical memory response

(2013) Jin-Shu He et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Omalizumab may decrease IgE synthesis by targeting membrane IgE+ human B cells

(2013) Marcia A Chan et al.   Clinical and Translational Allergy

The majority of allergen-specific IgE in the blood of allergic patients does not originate from blood-derived B cells or plasma cells

(2012) J. Eckl-Dorna et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Different modes of IgE binding to CD23 revealed with major birch allergen, Bet v 1-specific monoclonal IgE

(2012) Kavita Reginald et al.   IMMUNOLOGY AND CELL BIOLOGY

Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults

(2012) Christian Lupinek et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody

(2012) Seung Y. Chu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sequential class switching is required for the generation of high affinity IgE antibodies

(2012) Huizhong Xiong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tolerability, pharmacokinetics and pharmacodynamics of CMAB007, a humanized anti-immunoglobulin E monoclonal antibody, in healthy Chinese subjects

(2012) Bo Zhou et al.   mAbs

Ex vivo characterization and isolation of rare memory B cells with antigen tetramers

(2011) B. Franz et al.   BLOOD

Soluble IgE receptors—Elements of the IgE network

(2011) Barbara Platzer et al.   IMMUNOLOGY LETTERS

Facilitated antigen presentation and its inhibition by blocking IgG antibodies depends on IgE repertoire complexity

(2011) Jens Holm et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The who, where, and when of IgE in allergic airway disease

(2011) Melissa Dullaers et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD23-Dependent Transcytosis of IgE and Immune Complex across the Polarized Human Respiratory Epithelial Cells

(2011) S. Palaniyandi et al.   JOURNAL OF IMMUNOLOGY

Allergy transfer with hematopoietic cell transplantation from an unrelated donor

(2010) J Storek et al.   BONE MARROW TRANSPLANTATION

Microarray and allergenic activity assessment of milk allergens

(2010) H. Hochwallner et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Inhibition of CD23-dependent facilitated allergen binding to B cells following vaccination with genetically modified hypoallergenic Bet v 1 molecules

(2010) I. Pree et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Relationship between facilitated allergen presentation and the presence of allergen-specific IgE in serum of atopic patients

(2010) F. L. HEIJDEN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Visualization of clustered IgE epitopes on α-lactalbumin

(2010) Heidrun Hochwallner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice

(2010) Hans D. Brightbill et al.   JOURNAL OF CLINICAL INVESTIGATION

Murine B Cells Regulate Serum IgE Levels in a CD23-Dependent Manner

(2010) L. E. Cheng et al.   JOURNAL OF IMMUNOLOGY

Mouse models of allergic diseases

(2009) Katsuyuki Takeda et al.   CURRENT OPINION IN IMMUNOLOGY

DARPins as Bispecific Receptor Antagonists Analyzed for Immunoglobulin E Receptor Blockage

(2009) Alexander Eggel et al.   JOURNAL OF MOLECULAR BIOLOGY

Successful treatment of solar urticaria with anti-immunoglobulin E therapy

(2008) O. Güzelbey et al.   ALLERGY

The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells

(2008) M. Mamani-Matsuda et al.   BLOOD

A double-blind placebo-controlled birch allergy vaccination study II: correlation between inhibition of IgE binding, histamine release and facilitated allergen presentation

(2008) P. A. Würtzen et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Role of the spleen in peripheral memory B-cell homeostasis in patients with autoimmune thrombocytopenia purpura

(2008) Lorena Martinez-Gamboa et al.   CLINICAL IMMUNOLOGY

Local production of total IgE and specific antibodies to the house dust mite in adenoid tissue

(2008) Seung-Youp Shin et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Anti-Immunoglobulin E Therapy

(2008) Manav Segal et al.   World Allergy Organization Journal