Antioxidant Defenses: A Context-Specific Vulnerability of Cancer Cells

Antitumor potential of new low molecular weight antioxidative preparations from the white rot fungus Cerrena unicolor against human colon cancer cells

(2019) Anna Matuszewska et al.   Scientific Reports

Rosemary (Rosmarinus officinalis) extract causes ROS-induced necrotic cell death and inhibits tumor growth in vivo

(2019) Almudena Pérez-Sánchez et al.   Scientific Reports

FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels

(2019) Vicenta Trujillo-Alonso et al.   Nature Nanotechnology

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

(2019) Isaac S. Harris et al.   Cell Metabolism

Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers

(2019) Hideaki Ogiwara et al.   CANCER CELL

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

(2019) Yu-Ru Lee et al.   SCIENCE

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

(2019) Luca Lignitto et al.   CELL

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

(2019) Clotilde Wiel et al.   CELL

Garlic augments the functional and nutritional behavior of Doenjang, a traditional Korean fermented soybean paste

(2019) Ashutosh Bahuguna et al.   Scientific Reports

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

(2018) Nobuaki Takahashi et al.   CANCER CELL

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies

(2018) Gang Xiao et al.   CELL

RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells

(2018) Mark A. Hawk et al.   NATURE CELL BIOLOGY

Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth

(2018) Yuan Liu et al.   Nature Communications

Iron addiction: a novel therapeutic target in ovarian cancer

(2017) D Basuli et al.   ONCOGENE

Inhibition of cancer growth in vitro and in vivo by a novel ROS-modulating agent with ability to eliminate stem-like cancer cells

(2017) Jiankang Wang et al.   Cell Death & Disease

Effects of Ferroportin-Mediated Iron Depletion in Cells Representative of Different Histological Subtypes of Prostate Cancer

(2017) Zhiyong Deng et al.   ANTIOXIDANTS & REDOX SIGNALING

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

(2016) Evan C. Lien et al.   NATURE CELL BIOLOGY

NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis

(2016) Hui Wang et al.   Science Translational Medicine

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Decreased Ferroportin Promotes Myeloma Cell Growth and Osteoclast Differentiation

(2015) Zhimin Gu et al.   CANCER RESEARCH

Glucose addiction in cancer therapy: advances and drawbacks

(2015) Sara Granja et al.   CURRENT DRUG METABOLISM

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

(2015) J. Yun et al.   SCIENCE

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Overexpression of iASPP-SV in glioma is associated with poor prognosis by promoting cell viability and antagonizing apoptosis

(2015) Xiangrong Liu et al.   TUMOR BIOLOGY

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Chemotherapy in metastatic renal cell carcinoma today? A systematic review

(2013) Sebastiano Buti et al.   ANTI-CANCER DRUGS

Antioxidant Enzymes Mediate Survival of Breast Cancer Cells Deprived of Extracellular Matrix

(2013) C. A. Davison et al.   CANCER RESEARCH

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

(2013) Chiara Gorrini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Ten misconceptions about antioxidants

(2013) Aalt Bast et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Electron transfer-based combination therapy of cisplatin with tetramethyl-p-phenylenediamine for ovarian, cervical, and lung cancers

(2012) T. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regulation of cancer cell death and metabolism by extracellular matrix attachment

(2012) Cassandra L. Buchheit et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Indole-3-carbinol Generates Reactive Oxygen Species and Induces Apoptosis

(2011) In-sok Hwang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

iASPP and Chemoresistance in Ovarian Cancers: Effects on Paclitaxel-Mediated Mitotic Catastrophe

(2011) L. Jiang et al.   CLINICAL CANCER RESEARCH

Clinical trials of antioxidants as cancer prevention agents: Past, present, and future

(2011) Michael Goodman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation

(2011) A. R. Grassian et al.   GENES & DEVELOPMENT

Vitamin E and the Risk of Prostate Cancer

(2011) Eric A. Klein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis

(2010) Z. K. Pinnix et al.   Science Translational Medicine

Ferritin binds and activates p53 under oxidative stress

(2009) Jong-Hyuk Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein Kinase CK2 in Health and Disease

(2009) J. H. Trembley et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Relationship between the Antioxidant Capacity and Effect of Rosemary (Rosmarinus officinalis L.) Polyphenols on Membrane Phospholipid Order

(2009) Laura Pérez-Fons et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Multiple pathways regulated by the tumor suppressor PP2A in transformation

(2008) Jukka Westermarck et al.   TRENDS IN MOLECULAR MEDICINE