DNA Methylation of Enhancer Elements in Myeloid Neoplasms: Think Outside the Promoters?

Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene epigenetically regulated

(2019) Nicolás Martínez-Calle et al.   HAEMATOLOGICA

Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response

(2019) Xabier Agirre et al.   Nature Communications

BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses

(2019) Anup Dey et al.   EMBO JOURNAL

TET2 Function in Hematopoietic Malignancies, Immune Regulation, and DNA Repair

(2019) Yimei Feng et al.   Frontiers in Oncology

TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer

(2019) Chan-Wang J. Lio et al.   Science Immunology

Chronic myelomonocytic leukemia: 2018 update on diagnosis, risk stratification and management

(2018) Mrinal M. Patnaik et al.   AMERICAN JOURNAL OF HEMATOLOGY

Enhancer dysfunction in leukemia

(2018) Anand S. Bhagwat et al.   BLOOD

Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis

(2018) Pengxu Qian et al.   Cell Stem Cell

DNA methylation profile in chronic myelomonocytic leukemia associates with distinct clinical, biological and genetic features

(2018) Laura Palomo et al.   Epigenetics

Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate

(2018) Jose Luis Sardina et al.   Cell Stem Cell

TET2 coactivates gene expression through demethylation of enhancers

(2018) Lu Wang et al.   Science Advances

Polycomb-like proteins link the PRC2 complex to CpG islands

(2017) Haojie Li et al.   NATURE

Identification of H3K4me1-associated proteins at mammalian enhancers

(2017) Andrea Local et al.   NATURE GENETICS

Myeloproliferative Neoplasms

(2017) Jerry L. Spivak   NEW ENGLAND JOURNAL OF MEDICINE

BET Proteins as Targets for Anticancer Treatment

(2017) Anastasios Stathis et al.   Cancer Discovery

Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers

(2017) Jacob L. Glass et al.   Cancer Discovery

Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations

(2017) Helene Myrtue Nielsen et al.   Scientific Reports

EnhancerAtlas: a resource for enhancer annotation and analysis in 105 human cell/tissue types

(2016) Tianshun Gao et al.   BIOINFORMATICS

Cancer-specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemia

(2016) Ying Qu et al.   BLOOD

DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias

(2016) Liubin Yang et al.   CANCER CELL

Enhancer methylation dynamics contribute to cancer plasticity and patient mortality

(2016) Rachel E. Bell et al.   GENOME RESEARCH

Identification and function of enhancers in the human genome

(2016) Candice J. Coppola et al.   HUMAN MOLECULAR GENETICS

The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins

(2016) Yasushi Taniguchi   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Persistent DNMT3A mutation burden in DNMT3A mutated adult cytogenetically normal acute myeloid leukemia patients in long-term remission

(2016) Yanjun Sun et al.   LEUKEMIA RESEARCH

DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases

(2016) Varun Sasidharan Nair et al.   MOLECULES AND CELLS

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells

(2016) E. L. Soucie et al.   SCIENCE

In silico identification of enhancers on the basis of a combination of transcription factor binding motif occurrences

(2016) Yaping Fang et al.   Scientific Reports

Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells

(2016) Andrew D. King et al.   Cell Reports

Targeting epigenetic pathways in acute myeloid leukemia and myelodysplastic syndrome: a systematic review of hypomethylating agents trials

(2016) Seongseok Yun et al.   Clinical Epigenetics

Enhancers, enhancers – from their discovery to today’s universe of transcription enhancers

(2015) Walter Schaffner   BIOLOGICAL CHEMISTRY

TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia

(2015) J. Yamazaki et al.   CANCER RESEARCH

Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers

(2015) Xabier Agirre et al.   GENOME RESEARCH

Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia

(2015) Kristen Meldi et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

The nucleosome remodeling and deacetylase complex in development and disease

(2015) Jeannine Basta et al.   Translational Research

BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells

(2015) Marie-Magdelaine Coudé et al.   Oncotarget

Analysis of the DNA methylome and transcriptome in granulopoiesis reveals timed changes and dynamic enhancer methylation

(2014) M. Ronnerblad et al.   BLOOD

A Remote GATA2 Hematopoietic Enhancer Drives Leukemogenesis in inv(3)(q21;q26) by Activating EVI1 Expression

(2014) Hiromi Yamazaki et al.   CANCER CELL

A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia

(2014) Stefan Gröschel et al.   CELL

Role of Tet proteins in enhancer activity and telomere elongation

(2014) Falong Lu et al.   GENES & DEVELOPMENT

Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer

(2014) Phillippa C. Taberlay et al.   GENOME RESEARCH

Epigenetics in the hematologic malignancies

(2014) C. Y. Fong et al.   HAEMATOLOGICA

Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations

(2014) Karolina Skvarova Kramarzova et al.   Journal of Hematology & Oncology

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

(2014) Paul A. Northcott et al.   NATURE

Transcriptional enhancers: from properties to genome-wide predictions

(2014) Daria Shlyueva et al.   NATURE REVIEWS GENETICS

Association between DNMT3A Mutations and Prognosis of Adults with De Novo Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis

(2014) Ruxiu Tie et al.   PLoS One

Chromatin state dynamics during blood formation

(2014) D. Lara-Astiaso et al.   SCIENCE

Can genome engineering be used to target cancer-associated enhancers?

(2014) Matthew R Grimmer et al.   Epigenomics

Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancer

(2013) Marta Kulis et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Aberrant DNA methylation profile of chronic and transformed classic Philadelphia-negative myeloproliferative neoplasms

(2013) C. Perez et al.   HAEMATOLOGICA

DNMT3A mutation is a poor prognosis biomarker in AML: Results of a meta-analysis of 4500 AML patients

(2013) Velizar Shivarov et al.   LEUKEMIA RESEARCH

The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers

(2013) D. Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

Modification of Enhancer Chromatin: What, How, and Why?

(2013) Eliezer Calo et al.   MOLECULAR CELL

Polycomb-Dependent H3K27me1 and H3K27me2 Regulate Active Transcription and Enhancer Fidelity

(2013) Karin J. Ferrari et al.   MOLECULAR CELL

Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter

(2013) Hui Chen et al.   NUCLEIC ACIDS RESEARCH

Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites

(2013) Alexey Kozlenkov et al.   NUCLEIC ACIDS RESEARCH

Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA

(2013) Z Zou et al.   ONCOGENE

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

(2013) Ji-Eun Lee et al.   eLife

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

(2013) Jessica Nordlund et al.   GENOME BIOLOGY

DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes

(2013) Dvir Aran et al.   GENOME BIOLOGY

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

Long distance relationships: Enhancer–promoter communication and dynamic gene transcription

(2012) Judith Marsman et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Dynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states

(2012) T.-H. Pham et al.   BLOOD

Epigenetic reprogramming of cancer cells via targeted DNA methylation

(2012) Ashley G. Rivenbark et al.   Epigenetics

Effects ofTET2mutations on DNA methylation in chronic myelomonocytic leukemia

(2012) Jumpei Yamazaki et al.   Epigenetics

The accessible chromatin landscape of the human genome

(2012) Robert E. Thurman et al.   NATURE

Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers

(2012) Aurélien A. Sérandour et al.   NUCLEIC ACIDS RESEARCH

TET2 Mutations Are Associated with Specific 5-Methylcytosine and 5-Hydroxymethylcytosine Profiles in Patients with Chronic Myelomonocytic Leukemia

(2012) Cristina Pérez et al.   PLoS One

Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer

(2012) B. Akhtar-Zaidi et al.   SCIENCE

Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial

(2011) T. Braun et al.   BLOOD

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

(2011) Z. Li et al.   BLOOD

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

Functional and Mechanistic Diversity of Distal Transcription Enhancers

(2011) Michael Bulger et al.   CELL

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

DNA Demethylation Dynamics

(2011) Nidhi Bhutani et al.   CELL

DNA methylation status predicts cell type-specific enhancer activity

(2011) Malgorzata Wiench et al.   EMBO JOURNAL

Pioneer transcription factors: establishing competence for gene expression

(2011) K. S. Zaret et al.   GENES & DEVELOPMENT

Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions

(2011) Gabriel E. Zentner et al.   GENOME RESEARCH

DNA Methylation and Demethylation in Mammals

(2011) Zhao-xia Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Assessment of the Heterogeneous Methylation Status of CEBPA in Patients with Acute Myeloid Leukemia by Using High-Resolution Melting Profile

(2011) Tsung-Chin Lin et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

DNA-binding factors shape the mouse methylome at distal regulatory regions

(2011) Michael B. Stadler et al.   NATURE

Enhancer function: new insights into the regulation of tissue-specific gene expression

(2011) Chin-Tong Ong et al.   NATURE REVIEWS GENETICS

Relationship between Gene Body DNA Methylation and Intragenic H3K9me3 and H3K36me3 Chromatin Marks

(2011) Maria A. Hahn et al.   PLoS One

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

(2010) Maria E. Figueroa et al.   CANCER CELL

Transcriptional Enhancers in Animal Development and Evolution

(2010) Mike Levine   CURRENT BIOLOGY

Dynamic changes in the human methylome during differentiation

(2010) L. Laurent et al.   GENOME RESEARCH

Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia

(2010) I. H. I. M. Hollink et al.   HAEMATOLOGICA

A unique chromatin signature uncovers early developmental enhancers in humans

(2010) Alvaro Rada-Iglesias et al.   NATURE

Conserved role of intragenic DNA methylation in regulating alternative promoters

(2010) Alika K. Maunakea et al.   NATURE

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

(2010) Yingying Zhang et al.   NUCLEIC ACIDS RESEARCH

DNA Methylation Profiles and Their Relationship with Cytogenetic Status in Adult Acute Myeloid Leukemia

(2010) Sara Alvarez et al.   PLoS One

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing

(2009) F. Tie et al.   DEVELOPMENT

Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX–DNMT3–DNMT3L domain

(2009) Junji Otani et al.   EMBO REPORTS

Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity

(2009) C. Schmidl et al.   GENOME RESEARCH

Histone modifications at human enhancers reflect global cell-type-specific gene expression

(2009) Nathaniel D. Heintzman et al.   NATURE

Brd4 Coactivates Transcriptional Activation of NF- B via Specific Binding to Acetylated RelA

(2008) B. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-scale DNA methylation maps of pluripotent and differentiated cells

(2008) Alexander Meissner et al.   NATURE