TET2 Mutations Are Associated with Specific 5-Methylcytosine and 5-Hydroxymethylcytosine Profiles in Patients with Chronic Myelomonocytic Leukemia
Published 2012 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
TET2 Mutations Are Associated with Specific 5-Methylcytosine and 5-Hydroxymethylcytosine Profiles in Patients with Chronic Myelomonocytic Leukemia
Authors
Keywords
-
Journal
PLoS One
Volume 7, Issue 2, Pages e31605
Publisher
Public Library of Science (PLoS)
Online
2012-02-07
DOI
10.1371/journal.pone.0031605
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
- (2011) A. M. Jankowska et al. BLOOD
- TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis
- (2011) Cyril Quivoron et al. CANCER CELL
- Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation
- (2011) Kelly Moran-Crusio et al. CANCER CELL
- Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance
- (2011) V Grossmann et al. LEUKEMIA
- Frequent and Simultaneous Epigenetic Inactivation of TP53 Pathway Genes in Acute Lymphoblastic Leukemia
- (2011) Amaia Vilas–Zornoza et al. PLoS One
- Lyn- and PLC- 3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease
- (2010) W. Xiao et al. BLOOD
- Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value
- (2010) A. E. Smith et al. BLOOD
- Phase 2 study of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy
- (2010) H. M. Kantarjian et al. BLOOD
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation
- (2010) A. Puissant et al. CANCER RESEARCH
- TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine
- (2010) Haikuo Zhang et al. CELL RESEARCH
- IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis
- (2010) F. Thol et al. HAEMATOLOGICA
- Cytogenetic risk stratification in chronic myelomonocytic leukemia
- (2010) E. Such et al. HAEMATOLOGICA
- Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1
- (2010) Alexander Kohlmann et al. JOURNAL OF CLINICAL ONCOLOGY
- Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
- (2010) Myunggon Ko et al. NATURE
- Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
- (2010) Shinsuke Ito et al. NATURE
- Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
- (2010) Thomas Ernst et al. NATURE GENETICS
- TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)
- (2009) O. Kosmider et al. BLOOD
- DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia
- (2009) L. Milani et al. BLOOD
- The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
- (2009) J. W. Vardiman et al. BLOOD
- Mutations of polycomb-associated geneASXL1in myelodysplastic syndromes and chronic myelomonocytic leukaemia
- (2009) Véronique Gelsi-Boyer et al. BRITISH JOURNAL OF HAEMATOLOGY
- Tumor Suppression by Phospholipase C-β3 via SHP-1-Mediated Dephosphorylation of Stat5
- (2009) Wenbin Xiao et al. CANCER CELL
- Valproic Acid at Therapeutic Plasma Levels May Increase 5-Azacytidine Efficacy in Higher Risk Myelodysplastic Syndromes
- (2009) M. T. Voso et al. CLINICAL CANCER RESEARCH
- Genome-wide DNA methylation profiling using Infinium®assay
- (2009) Marina Bibikova et al. Epigenomics
- New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling
- (2008) J. I. Martin-Subero et al. BLOOD
- Aberrant DNA methylation is a dominant mechanism in MDS progression to AML
- (2008) Y. Jiang et al. BLOOD
- c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia
- (2008) E D Lagadinou et al. LEUKEMIA
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started