Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach

Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages

(2018) Marco Paolino et al.   ChemMedChem

Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues

(2018) Alessandra Vallone et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation

(2018) Simone Brogi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents

(2018) Margherita Brindisi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

(2017) Simone Brogi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of novel fluorescent probes preventing PrP Sc replication in prion diseases

(2017) Ludovica Zaccagnini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural characterization of Giardia duodenalis thioredoxin reductase ( g TrxR) and computational analysis of its interaction with NBDHEX

(2017) Simone Brogi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of novel cyclic peptides as pro-apoptotic agents

(2016) Margherita Brindisi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis

(2016) Claudia C. Maquiaveli et al.   JOURNAL OF NATURAL PRODUCTS

Ether Cleavage Re-Investigated: Elucidating the Mechanism of BBr3-Facilitated Demethylation of Aryl Methyl Ethers

(2015) Talon M. Kosak et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Novel synthetic approach to fluoro- and amido-disubstituted 3-hydroxypyridin-4-ones

(2015) Yongmin Ma et al.   JOURNAL OF FLUORINE CHEMISTRY

Design, synthesis and anti-HIV-1 evaluation of a series of 5-hydroxypyridine-4-one derivatives as possible integrase inhibitors

(2015) Mahboubeh Rostami et al.   MEDICINAL CHEMISTRY RESEARCH

Synthetic spirocyclic endoperoxides: new antimalarial scaffolds

(2015) Margherita Brindisi et al.   MedChemComm

Discovery and Cardioprotective Effects of the First Non-Peptide Agonists of the G Protein-Coupled Prokineticin Receptor-1

(2015) Adeline Gasser et al.   PLoS One

Suzuki-Miyaura Cross-Coupling Reactions of Unprotected Haloimidazoles

(2014) Jiajing Tan et al.   JOURNAL OF ORGANIC CHEMISTRY

Docking studies of some 5-hydroxypyridine-4-one derivatives: evaluation of integrase and ribonuclease H domain of reverse transcriptase as possible targets for anti-HIV-1 activity

(2014) Hajar Sirous et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds

(2013) Andrea Cappelli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibiting the HIV Integration Process: Past, Present, and the Future

(2013) Roberto Di Santo   JOURNAL OF MEDICINAL CHEMISTRY

Clauson–Kaas-Type Synthesis of Pyrrolyl-phenols, from the Hydrochlorides of Aminophenols, in the Presence of Nicotinamide

(2013) Maria Chatzopoulou et al.   SYNTHETIC COMMUNICATIONS

Viral enzymes containing magnesium: Metal binding as a successful strategy in drug design

(2012) Dominga Rogolino et al.   COORDINATION CHEMISTRY REVIEWS

Dolutegravir for the treatment of HIV

(2012) Christine Katlama et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

ZINC: A Free Tool to Discover Chemistry for Biology

(2012) John J. Irwin et al.   Journal of Chemical Information and Modeling

The FAF-Drugs2 server: a multistep engine to prepare electronic chemical compound collections

(2011) David Lagorce et al.   BIOINFORMATICS

Hydroxypyridinones as “privileged” chelating structures for the design of medicinal drugs

(2011) M. Amélia Santos et al.   COORDINATION CHEMISTRY REVIEWS

Authentic HIV-1 integrase inhibitors

(2010) Chenzhong Liao et al.   Future Medicinal Chemistry

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophore Modeling for Qualitative Prediction of Antiestrogenic Activity

(2009) Simone Brogi et al.   Journal of Chemical Information and Modeling

Quinolone Carboxylic Acids as a Novel Monoketo Acid Class of Human Immunodeficiency Virus Type 1 Integrase Inhibitors

(2009) Motohide Sato et al.   JOURNAL OF MEDICINAL CHEMISTRY

FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects

(2008) David Lagorce et al.   BMC BIOINFORMATICS

Advances in two-metal chelation inhibitors of HIV integrase

(2008) Brian A Johns et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Defining the DNA Substrate Binding Sites on HIV-1 Integrase

(2008) James Dolan et al.   JOURNAL OF MOLECULAR BIOLOGY

Assessing the Role of Polarization in Docking

(2008) Christopher J. R. Illingworth et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Integrase and integration: biochemical activities of HIV-1 integrase

(2008) Olivier Delelis et al.   Retrovirology