Article
Cell & Tissue Engineering
Chun-Wei Chen, Linda Zhang, Ravi Dutta, Abhishek Niroula, Peter G. Miller, Christopher J. Gibson, Alexander G. Bick, Jaime M. Reyes, Yi-Tang Lee, Ayala Tovy, Tianpeng Gu, Sarah Waldvogel, Yi-Hung Chen, Bryan J. Venters, Pierre-Olivier Esteve, Sriharsa Pradhan, Michael-Christopher Keogh, Pradeep Natarajan, Koichi Takahashi, Adam S. Sperling, Margaret A. Goodell
Summary: This study describes the context and mechanisms leading to the enrichment of hematopoietic stem cells (HSCs) with SRCAP mutations. The authors demonstrate that SRCAP mutations confer a selective advantage in both human cells and mice, resulting in lymphoid-biased expansion. These findings provide new insight into the functional impact of genetic variants promoting stem cell competition in the hematopoietic system.
Article
Multidisciplinary Sciences
Davide G. Berta, Heli Kuisma, Niko Valimaki, Maritta Raisanen, Maija Jantti, Annukka Pasanen, Auli Karhu, Jaana Kaukomaa, Aurora Taira, Tatiana Cajuso, Sanna Nieminen, Rosa-Maria Penttinen, Saija Ahonen, Rainer Lehtonen, Miika Mehine, Pia Vahteristo, Jyrki Jalkanen, Biswajyoti Sahu, Janne Ravantti, Netta Makinen, Kristiina Rajamaki, Kimmo Palin, Jussi Taipale, Oskari Heikinheimo, Ralf Butzow, Eevi Kaasinen, Lauri A. Aaltonen
Summary: One in four women suffer from uterine leiomyomas (ULs) at some point in premenopausal life, which can cause excessive bleeding, pain, and infertility. Recent research identified mutations in genes encoding members of the SRCAP histone-loading complex as potential drivers of UL, indicating a potential mechanism of tumorigenesis involving epigenetic instability caused by deficient H2A.Z deposition.
Article
Biochemistry & Molecular Biology
Kewei Sun, Yiqing Li, Yunpeng Gai, Jingrui Wang, Yunqing Jian, Xin Liu, Liang Wu, Won-Bo Shim, Yin-Won Lee, Zhonghua Ma, Hubertus Haas, Yanni Yin
Summary: The study found that wheat heads are exposed to iron excess during infection by Fusarium graminearum, and the genes FgHapX and FgSreA play key roles in adapting to iron excess. FgHapX promotes iron storage by regulating the transcriptional activity of relevant genes, while FgSreA inhibits iron acquisition by facilitating the deposition and modification of relevant genes.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biology
Bhagyshree Jamge, Zdravko J. Lorkovic, Elin Axelsson, Akihisa Osakabe, Vikas Shukla, Ramesh Yelagandula, Svetlana Akimcheva, Annika Luisa Kuehn, Frederic Berger
Summary: This study investigates the assembly of histone variants and histone modifications in Arabidopsis thaliana genome and finds that both histone variants and modifications play significant roles in determining chromatin states. Particularly, there are strong associations between H2A variants and specific combinations of histone modifications. The loss of the chromatin remodeler DDM1 affects the exchange of histone variant H2A.Z, resulting in significant effects on the definition and distribution of chromatin states.
Article
Biochemistry & Molecular Biology
Chengcheng Zhang, Yuan Tian, Shuang Song, Lu Zhang, Yunkun Dang, Qun He
Summary: The deposition of H2A.Z and deacetylation of histone H3 lysine 56 play crucial roles in restricting heterochromatin spreading.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kai Ni, Kathrin Muegge
Summary: LSH, a homologue of the ISWI/SNF2 family of chromatin remodelers, is shown to interact with macroH2A1 and macroH2A2 in vitro and catalyze the transfer of macroH2A into mono-nucleosomes in an ATP dependent manner. This newly discovered role of LSH in chromatin remodeling provides a novel molecular mechanism for deposition of the histone variant macroH2A.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Cell Biology
Kathryn M. Stevens, Tobias Warnecke
Summary: Exchanging core histones in the nucleosome for paralogous variants can have important functional ramifications. Many of these variants and their physiological roles have been extensively studied in model eukaryotes, but our knowledge of histone biology in archaea, including histone variants, remains limited. Recent findings provide glimpses into the unknown world of archaeal histone biology, offering insights into chromatin organization and shedding light on the evolution of histone-based chromatin in eukaryotes.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Alessandro Scacchetti, Peter B. Becker
Summary: Histone variant H2A.Z, incorporated into chromatin by SWR1-type remodelers, plays a key role in transcriptional regulation. Tight transcriptional control by H2A.Z nucleosomes relies on other histone variants or chromatin modifications, such as histone acetylation. Functional cooperation between SWR1-type remodelers and NuA4 histone acetyltransferase complexes is structurally implemented through species-specific strategies, a recurring theme in evolution.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Article
Biology
Diyan Li, Mengnan He, Qianzi Tang, Shilin Tian, Jiaman Zhang, Yan Li, Danyang Wang, Long Jin, Chunyou Ning, Wei Zhu, Silu Hu, Keren Long, Jideng Ma, Jing Liu, Zhihua Zhang, Mingzhou Li
Summary: The three-dimensional architecture of the genome plays a crucial role in gene expression regulation and conservation across species. This study compares the 3D genomes of fish, chickens, and 10 mammalian species, and reveals that genome size and chromosome length influence the higher hierarchical organization of the genome, while local transcriptional availability is selected through vertebrate evolution. Additionally, conservation of topologically associating domains is associated with modularity of expression profiles, and LINE and SINE transposable elements contribute to heterochromatin and euchromatin organization during genome evolution.
Article
Multidisciplinary Sciences
Xueqin Sun, Olaf Klingbeil, Bin Lu, Caizhi Wu, Carlos Ballon, Meng Ouyang, Xiaoli S. Wu, Ying Jin, Yon Hwangbo, Yu-Han Huang, Tim D. D. Somerville, Kenneth Chang, Jung Park, Taemoon Chung, Scott K. K. Lyons, Junwei Shi, Hannes Vogel, Michael Schulder, Christopher R. R. Vakoc, Alea A. A. Mills
Summary: Research uncovers a GBM-specific epigenetic mechanism where the chromatin regulator BRD8 inhibits p53 transactivation by maintaining H2AZ occupancy at p53 target loci, leading to sustained proliferation in TP53 wild-type GBM.
Article
Genetics & Heredity
Yukiko Kuroda, Aiko Iwata-Otsubo, Kerith-Rae Dias, Suzanna E. L. Temple, Koji Nagao, Lachlan De Hayr, Ying Zhu, Shin-Ya Isobe, Gohei Nishibuchi, Sarah K. Fiordaliso, Yuki Fujita, Alyssa L. Rippert, Samuel W. Baker, Marco L. Leung, Daniel C. Koboldt, Adele Harman, Beth A. Keena, Izumi Kazama, Gopinath Musuwadi Subramanian, Kandamurugu Manickam, Betsy Schmalz, Maeson Latsko, Elaine H. Zackai, Matt Edwards, Carey-Anne Evans, Matthew C. Dulik, Michael F. Buckley, Toshihide Yamashita, W. Timothy O'Brien, Robert J. Harvey, Chikashi Obuse, Tony Roscioli, Kosuke Izumi
Summary: This study identified heterozygous de novo variants in the CBX1 gene, encoding HP1β, as a cause of a novel syndromic neurodevelopmental disorder. In vitro cellular assays, neurobehavioral and cytological analyses of neuronal cells, and mouse models confirmed the pathogenicity of the identified variants. The disruption of HP1β chromatin binding during neurocognitive development contributes to developmental disabilities.
GENETICS IN MEDICINE
(2023)
Article
Cell Biology
Zhihui Liu, Weiguo Wang, Yuhan Xia, Yuan Gao, Zhisong Wang, Mingyang Li, Giorgio Antonio Presicce, Liyou An, Fuliang Du
Summary: This study reveals the changes in the epigenetic modification pattern of H4K20me3 during fertilization and somatic cell nuclear transfer (NT). The results show that there are differences in the H4K20me3 pattern between fertilized embryos, NT embryos, and parthenogenetic activation (PA) embryos. H4K20me3 is only present in the maternal pronuclei of fertilized embryos. The intensity of H4K20me3 is significantly lower in fertilized embryos compared to NT and PA embryos. Knockdown of Suv4-20h2 improves the development and cloning efficiency of NT embryos by upregulating reprogramming factors and ZGA-related factors.
CELL PROLIFERATION
(2023)
Review
Cell Biology
Frederic Berger, Kathrin Muegge, Eric J. Richards
Summary: Different variants of the histone H2A are found in distinct locations in the genome, but the mechanisms responsible for depositing specific H2A variants are not well understood. However, there are exceptions, such as chromatin remodelers that control H2A.Z dynamics at promoters. This review focuses on the identification of a specific class of chromatin remodelers (LSH and DDM1) that deposit the variants macroH2A in mammals and H2A.W in plants, respectively, and discusses their function in heterochromatin and genome stability.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hitoshi Kurumizaka, Tomoya Kujirai, Yoshimasa Takizawa
Summary: Chromatin compacts genomic DNA through nucleosome core particles, with versatile structure and dynamics for epigenetic regulation of genomic DNA. Histone variants in higher eukaryotes contribute to nucleosome diversity and play important roles in chromatin epigenetic regulation.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Oncology
Martin Salamini-Montemurri, Monica Lamas-Maceiras, Aida Barreiro-Alonso, Angel Vizoso-Vazquez, Esther Rodriguez-Belmonte, Maria Quindos-Varela, Maria Esperanza Cerdan
Article
Oncology
Maria Camara-Quilez, Aida Barreiro-Alonso, Angel Vizoso-Vazquez, Esther Rodriguez-Belmonte, Maria Quindos-Varela, Monica Lamas-Maceiras, Maria Esperanza Cerdan
Correction
Biotechnology & Applied Microbiology
Raphael Hermano Santos Diniz, Juan C. Villada, Mariana Caroline Tocantins Alvim, Pedro Marcus Pereira Vidigal, Nivea Moreira Vieira, Monica Lamas-Maceiras, Maria Esperanza Cerdan, Maria-Isabel Gonzalez-Siso, Petri-Jaan Lahtvee, Wendel Batista da Silveira
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Oncology
Aida Barreiro-Alonso, Monica Lamas-Maceiras, Lidia Lorenzo-Catoira, Mercedes Pardo, Lu Yu, Jyoti S. Choudhary, M. Esperanza Cerdan
Summary: The study reveals new protein interactions of HMGB1 in prostate and ovary cancers, indicating connections to RNA processing and ribosome biogenesis. The findings suggest potential targets for diagnosis and therapy, and highlight the functional significance of key regulators in cancer progression.
Article
Biochemistry & Molecular Biology
Agustin Rico-Diaz, Aida Barreiro-Alonso, Cora Rey-Souto, Manuel Becerra, Monica Lamas-Maceiras, M. Esperanza Cerdan, Angel Vizoso-Vazquez
Summary: The study revealed common functions between KlIxr1 and ScIxr1 in regulating gene transcription in response to external changes, but differences in oxidative stress induced by chemical treatments. Furthermore, KlIxr1 is able to bind specific DNA sequences, providing a new mechanism for cellular metabolism maintenance.
Editorial Material
Biochemistry & Molecular Biology
Aida Barreiro-Alonso, Angel Vizoso-Vazquez, Monica Lamas-Maceiras, Maria-Esperanza Cerdan
Article
Biochemistry & Molecular Biology
Carmen Alarcon-Veleiro, Rocio Mato-Basalo, Sergio Lucio-Gallego, Andrea Vidal-Pampin, Maria Quindos-Varela, Thamer Al-Qatarneh, German Berrecoso, Angel Vizoso-Vazquez, Maria C. Arufe, Juan Fafian-Labora
Summary: Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer, and current treatment methods are not satisfactory due to the development of chemo-resistance. Recently, ferroptosis, a new form of regulated cell death, has been found to be a promising anti-tumor strategy for EOC treatment.
Review
Microbiology
Monica Lamas-Maceiras, Angel Vizoso-Vazquez, Aida Barreiro-Alonso, Maria Camara-Quilez, Maria Esperanza Cerdan
Summary: This article summarizes the significant role of yeasts in the field of life sciences and their utilization as research tools. The study of yeasts has provided valuable insights into cellular functions and gene expression regulation.
Article
Biochemistry & Molecular Biology
Martin Salamini-Montemurri, Monica Lamas-Maceiras, Lidia Lorenzo-Catoira, Angel Vizoso-Vazquez, Aida Barreiro-Alonso, Esther Rodriguez-Belmonte, Maria Quindos-Varela, M. Esperanza Cerdan
Summary: This study conducted a meta-analysis of gene expression profiling studies on epithelial ovarian cancer (EOC) patients to identify lncRNA genes that have diagnostic and prognostic value. A panel of highly correlated lncRNAs with EOC was established, including both known and previously uncorrelated lncRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Andreia Cruz, Fiz da Costa, Jenyfer Fernandez-Perez, Ana Nanton, Sergio Fernandez-Boo, Ana Insua, Josefina Mendez