Osteosarcoma in the Post Genome Era: Preclinical Models and Approaches to Identify Tractable Therapeutic Targets

The Clonal Evolution of Metastatic Osteosarcoma as Shaped by Cisplatin Treatment

(2019) Samuel W. Brady et al.   MOLECULAR CANCER RESEARCH

Exploring the Potential Utility of Pet Dogs With Cancer for Studying Radiation-Induced Immunogenic Cell Death Strategies

(2019) Timothy M. Fan et al.   Frontiers in Oncology

Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation

(2019) Yujiao Han et al.   JOURNAL OF CLINICAL INVESTIGATION

Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways

(2019) Christopher D. Steele et al.   CANCER CELL

Naturally occurring cancers in pet dogs as pre-clinical models for cancer immunotherapy

(2019) Lidia Tarone et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

PATIENT-DERIVED XENOGRAFTS AS A PRECLINICAL MODEL FOR BONE SARCOMAS

(2018) WALTER MEOHAS et al.   Acta Ortopedica Brasileira

Establishment and characterization of novel patient-derived osteosarcoma xenograft and cell line

(2018) Fusako Kito et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Murine models of osteosarcoma: A piece of the translational puzzle

(2018) Mannu K. Walia et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma

(2018) Yang W. Shao et al.   ONCOGENE

Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53

(2018) Mannu K. Walia et al.   Cell Death & Disease

Combinatorial screening using orthotopic patient derived xenograft-expanded early phase cultures of osteosarcoma identify novel therapeutic drug combinations

(2018) Amos H.P. Loh et al.   CANCER LETTERS

Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein

(2017) Rasoul Pourebrahim et al.   GENES & DEVELOPMENT

Immunohistochemical Validation of Spontaneously Arising Canine Osteosarcoma as a Model for Human Osteosarcoma

(2017) A.A. Al-Khan et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Comparative Oncology Evaluation of Intravenous Recombinant Oncolytic Vesicular Stomatitis Virus Therapy in Spontaneous Canine Cancer

(2017) Shruthi Naik et al.   MOLECULAR CANCER THERAPEUTICS

Comparing the incidence of bone tumors in rats chronically exposed to the selective PTH type 1 receptor agonist abaloparatide or PTH(1–34)

(2017) Jacquelin Jolette et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Prospective evaluation of toceranib phosphate in metastatic canine osteosarcoma

(2017) T. Laver et al.   Veterinary and Comparative Oncology

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

(2017) Sam Behjati et al.   Nature Communications

Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine origin

(2017) Jahnabi Roy et al.   PLoS One

Whole-exome sequencing in osteosarcoma reveals important heterogeneity of genetic alterations

(2016) M. Bousquet et al.   ANNALS OF ONCOLOGY

Intra- and interspecies gene expression models for predicting drug response in canine osteosarcoma

(2016) Jared S. Fowles et al.   BMC BIOINFORMATICS

Immunotherapy with a HER2-Targeting Listeria Induces HER2-Specific Immunity and Demonstrates Potential Therapeutic Effects in a Phase I Trial in Canine Osteosarcoma

(2016) N. J. Mason et al.   CLINICAL CANCER RESEARCH

The Childhood Solid Tumor Network: A new resource for the developmental biology and oncology research communities

(2016) Elizabeth Stewart et al.   DEVELOPMENTAL BIOLOGY

IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα

(2016) Tanmay M. Shekhar et al.   Oncotarget

Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance

(2016) Mannu K Walia et al.   eLife

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma

(2015) A. Gupte et al.   CLINICAL CANCER RESEARCH

RECQL4 Regulates p53 Function In Vivo During Skeletogenesis

(2015) Linchao Lu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Germline TP53 Variants and Susceptibility to Osteosarcoma

(2015) Lisa Mirabello et al.   JNCI-Journal of the National Cancer Institute

Establishment of a patient-derived orthotopic osteosarcoma mouse model

(2015) Claudia Blattmann et al.   Journal of Translational Medicine

The Immunotherapy of Canine Osteosarcoma: A Historical and Systematic Review

(2015) K.L. Wycislo et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

(2015) Branden S Moriarity et al.   NATURE GENETICS

Comparative oncology: what dogs and other species can teach us about humans with cancer

(2015) Joshua D. Schiffman et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

RANKL blockade prevents and treats aggressive osteosarcomas

(2015) Yan Chen et al.   Science Translational Medicine

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency

(2015) Michal Kovac et al.   Nature Communications

Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations

(2015) Susanne Lorenz et al.   Oncotarget

BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells

(2015) Emma K Baker et al.   Scientific Reports

The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation

(2015) Alvin J. M. Ng et al.   PLoS Genetics

Germline TP53 Variants and Susceptibility to Osteosarcoma

(2015) Lisa Mirabello et al.   JNCI-Journal of the National Cancer Institute

Impact of Toceranib/Piroxicam/Cyclophosphamide Maintenance Therapy on Outcome of Dogs with Appendicular Osteosarcoma following Amputation and Carboplatin Chemotherapy: A Multi-Institutional Study

(2015) Cheryl A. London et al.   PLoS One

Cells of origin in osteosarcoma: Mesenchymal stem cells or osteoblast committed cells?

(2014) Anthony J. Mutsaers et al.   BONE

Notch Activation as a Driver of Osteogenic Sarcoma

(2014) Jianning Tao et al.   CANCER CELL

Canine Osteosarcoma: A Naturally Occurring Disease to Inform Pediatric Oncology

(2014) J. M. Fenger et al.   ILAR JOURNAL

The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse

(2014) T Quist et al.   ONCOGENE

Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo

(2014) P W M Ho et al.   ONCOGENE

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

(2014) Jennifer A. Perry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle

(2014) François Lamoureux et al.   Nature Communications

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

(2014) Xiang Chen et al.   Cell Reports

Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA

(2013) Anthony J. Mutsaers et al.   BONE

Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas

(2013) Christine G. Joseph et al.   GENES CHROMOSOMES & CANCER

Cross Talk from Pets to People: Translational Osteosarcoma Treatments

(2013) S. J. Withrow et al.   ILAR JOURNAL

A multi-site feasibility study for personalized medicine in canines with Osteosarcoma

(2013) Noel R Monks et al.   Journal of Translational Medicine

Outcome for adolescent and young adult patients with osteosarcoma

(2012) Katherine A. Janeway et al.   CANCER

Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

(2012) Dongsu Park et al.   Cell Stem Cell

Osteosarcoma in Sprague-Dawley rats after long-term treatment with teriparatide (human parathyroid hormone (1-34))

(2012) Atsushi Watanabe et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Inflammation, Apoptosis, and Necrosis Induced by Neoadjuvant Fas Ligand Gene Therapy Improves Survival of Dogs With Spontaneous Bone Cancer

(2012) Jaime F Modiano et al.   MOLECULAR THERAPY

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Osteosarcoma incidence and survival rates from 1973 to 2004

(2009) Lisa Mirabello et al.   CANCER

Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice

(2009) P. P. Lin et al.   CARCINOGENESIS

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease

(2008) C. R. Walkley et al.   GENES & DEVELOPMENT

Lack of Bone Neoplasms and Persistence of Bone Efficacy in Cynomolgus Macaques After Long-Term Treatment With Teriparatide [rhPTH(1-34)]*

(2008) John L Vahle et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteosarcoma: The Addition of Muramyl Tripeptide to Chemotherapy Improves Overall Survival—A Report From the Children's Oncology Group

(2008) Paul A. Meyers et al.   JOURNAL OF CLINICAL ONCOLOGY

Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

(2008) S. D. Berman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA