Review
Otorhinolaryngology
Estela Kaminagakura, Rubens Nisie Tango, Danyel Cruz-Perez, Roberta Bonan, Luciana Yamamoto de Almeida, Maria Leticia de Almeida Lanca, Paulo Bonan, Helder Martins, Ademar Takahama Jr, Fabio Augusto Ito, Claudia Malheiros Coutinho-Camillo, Silvia Vanessa Lourenco, Taciana Caneppele, Andrew G. Sikora, Luiz Paulo Kowalski, Simon Young
Summary: Young patients with oral cavity squamous cell carcinoma (OSCC) have a higher relapse rate and worse 5-year disease-free survival (DFS) compared to older patients, although the 5-year overall survival (OS) is similar between the two groups.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Urology & Nephrology
Lloyd J. W. Tack, Alexander Springer, Stefan Riedl, Ursula Tonnhofer, Manuela Hiess, Julia Weninger, Ahmed Mahmoud, Erik Van Laecke, Piet Hoebeke, Martine Cools, Anne-Francoise Spinoit
Summary: This study evaluated the long-term surgical, functional urinary and sexual outcomes of adolescent and young adult men who underwent childhood hypospadias repair, finding that 52.9% of cases had concerns requiring long-term follow-up. Patients who had their hypospadias repair before 12 months of age had higher rates of reinterventions. Adopting a restrained approach to aesthetic refinements may lead to better urinary outcomes.
JOURNAL OF UROLOGY
(2021)
Review
Oncology
Brooke Cherven, Amani Sampson, Sharon L. Bober, Kristin Bingen, Natasha Frederick, David R. Freyer, Gwendolyn P. Quinn
Summary: This study summarizes the literature on sexual function among adolescent and young adult cancer survivors, finding that they experience a burden of sexual dysfunction and interventions are needed to support sexual health and psychosexual adjustment. Collaboration between organizations is necessary to advance assessment of sexual dysfunction and test interventions to improve sexual health among this population.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Medicine, General & Internal
Carol A. Ford, Andrew C. Pool, Nicole F. Kahn, James Jaccard, Carolyn T. Halpern
Summary: This cohort study suggests that positive parent-adolescent relationships are associated with favorable outcomes in young adulthood. Investments in improving these relationships may have long-term benefits for young adult health.
Article
Oncology
Andrea C. Betts, L. Aubree Shay, Philip J. Lupo, Sandi L. Pruitt, Michael E. Roth, Marlyn A. Allicock, Barbara A. Cohn, Caitlin C. Murphy
Summary: This study examined adverse birth outcomes among adolescent and young adult women diagnosed with cancer during pregnancy. The results showed that cancer diagnosis was significantly associated with adverse birth outcomes such as low birth weight and preterm birth in this population.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Obstetrics & Gynecology
Chelsea Anderson, Victoria Fitz, Allison Deal, Darios Getahun, Marilyn L. Kwan, Jennifer E. Mersereau, Lawrence H. Kushi, Chun R. Chao, Hazel B. Nichols
Summary: This study examines the association between demographic and cancer-related characteristics and factors such as fertility discussion and fertility preservation use with attempting pregnancy after adolescent and young adult cancer. The use of fertility preservation strategies was found to be significantly associated with attempting pregnancy after cancer.
FERTILITY AND STERILITY
(2023)
Article
Oncology
Christopher Kuo, Jemily Malvar, Yueh-Yun Chi, Eugene S. Kim, Rachana Shah, Fariba Navid, James E. Stein, Leo Mascarenhas
Summary: This study compared the survival outcomes and post-operative morbidities of different surgical approaches in patients with osteosarcoma (OST) pulmonary metastases. The results showed that the surgical approach did not significantly affect survival outcomes, but thoracotomy was associated with more post-operative morbidities.
Review
Oncology
Safia K. Ahmed, Sameer R. Keole
Summary: This article discusses the usefulness of proton beam radiation therapy in the treatment of common cancers in the adolescent and young adult population. Proton beam radiation therapy may reduce the risk of radiation-associated side effects for this population without compromising treatment efficacy. Current literature suggests that proton beam radiation therapy has utility in the treatment of certain cancers in this population, and research is ongoing to further establish its role.
Article
Oncology
Yanchuan Pu, Jin Wang, Jianshu Wang, Shizhong Wang
Summary: The utility of preoperative D-dimer and plasma fibrinogen levels in predicting the clinical value of osteosarcoma patients was evaluated. Elevated D-dimer levels were associated with aggressive clinicopathological features and poor survival outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Elise Lavit, Mihaela Aldea, Sophie Piperno-Neumann, Nelly Firmin, Antoine Italiano, Nicolas Isambert, Jean-Emmanuel Kurtz, Corinne Delcambre, Valerie Lebrun, Pauline Soibinet-Oudot, Christine Chevreau, Emmanuelle Bompas, Christine Le Maignan, Pascaline Boudou-Rouquette, Axel Le Cesne, Julien Mancini, Jean-Yves Blay, Florence Duffaud
Summary: Treatment options for metastatic osteosarcomas are limited, and surgical removal of metastases is crucial for patient prognosis. Patients who relapse often receive multiple lines of systemic therapy and may be enrolled in clinical trials if available.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Jin Luo, Biyu Diao, Jinqiu Wang, Ke Yin, Shenchao Guo, Chenyan Hong, Yu Guo
Summary: The objective of this study was to construct a new clinical risk stratification system to predict overall survival in adolescent and young adult women with breast cancer. A prognostic predictive model was built using a deep learning algorithm called DeepSurv, based on data from the SEER database. The study found that the clinical risk stratification based on the total risk score derived from the prognostic predictive model had good prediction accuracy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Pediatrics
Nathan Cantor, Mila Kingsbury, Emily Warner, Hannah Landry, Zahra Clayborne, Raidah Islam, Ian Colman
Summary: This study systematically assessed the relationship between adolescent suicidal ideation and suicide attempts with young adult psychopathological outcomes. The findings showed that adolescent suicidal ideation was associated with young adult suicide attempt, depressive disorders, and anxiety disorders, while adolescent suicide attempts were associated with young adult suicide attempt and anxiety disorders.
Article
Oncology
Olga Husson, Bryce B. Reeve, Anne-Sophie Darlington, Christabel K. Cheung, Samantha Sodergren, Winette T. A. van der Graaf, John M. Salsman
Summary: The relatively small number of cancers in the adolescent and young adult age group does not reflect the true impact of the disease. Collaborative efforts are needed to develop a core outcome set (COS) for this population, which will improve care and outcomes by providing standardized measures of success. Implementation of a globally agreed COS will also facilitate better data pooling and benchmarking.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Review
Oncology
Silvie H. M. Janssen, Winette T. A. van der Graaf, Daniel J. van der Meer, Eveliene Manten-Horst, Olga Husson
Summary: Adolescent and young adult (AYA) cancer patients, aged 15-39 years old, face unique challenges in their disease trajectory. Although the number of AYA cancer survivors has increased, they are at risk of long-term and late effects. Research efforts are needed to inform survivorship care for this growing population.
Article
Oncology
Smita Bhatia, Alberto S. Pappo, Melissa Acquazzino, Wendy A. Allen-Rhoades, Marie Barnett, Scott C. Borinstein, Robert Casey, Sun Choo, Rashmi Chugh, Shira Dinner, Ralph Ermoian, Douglas Fair, Noah Federman, Jeanelle Folbrecht, Shipra Gandhi, Julie Germann, Robert Goldsby, Robert Hayashi, Alex Y. Huang, Mary S. Huang, Linda A. Jacobs, Cathy Lee-Miller, Michael P. Link, John A. Livingston, Maryam Lustberg, Marcio Malogolowkin, Kevin C. Oeffinger, Christine A. Pratilas, Damon Reed, Jodi Skiles, Margaret von Mehren, Nicholas Yeager, Sarah Montgomery, Lisa Hang
Summary: This article discusses considerations for the comprehensive care of adolescent and young adult (AYA) patients with cancer, based on the NCCN Guidelines for AYA Oncology. AYA patients have unique needs in terms of treatment, fertility counseling, psychosocial and behavioral issues, and supportive care services compared to older adults with cancer.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Pathology
Xinyi Zhang, Shidan Wang, Erin R. Rudzinski, Saloni Agarwal, Ruichen Rong, Donald A. Barkauskas, Ovidiu Daescu, Lauren Furman Cline, Rajkumar Venkatramani, Yang Xie, Guanghua Xiao, Patrick Leavey
Summary: This study developed a computational algorithm for subtype classification and prognosis prediction of rhabdomyosarcoma (RMS) using pathology images. The algorithm achieved good performance in classification and prediction on the test dataset, providing assistance in pathology evaluation and risk stratification.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Letter
Oncology
G. A. Amos Burke, Veronique Minard-Colin, Anne Auperin, Sarah Alexander, Marta Pillon, Rafael Delgado, Jozsef Zsiros, Anne Uyttebroeck, Peggy Dartigues, Rodney R. Miles, Bernarda Kazanowska, Alan K. Chiang, Stephanie Haouy, Catherine M. Bollard, Monika Csoka, Keith Wheatley, Donald A. Barkauskas, Peter C. Adamson, Gilles Vassal, Catherine Patte, Thomas G. Gross
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Qing Yang, Jiemiao Hu, Zhiliang Jia, Qi Wang, Jing Wang, Long Hoang Dao, Wendong Zhang, Sheng Zhang, Xueqing Xia, Richard Gorlick, Shulin Li
Summary: This study proposes a new cell therapy for treating osteosarcoma. By introducing a specific protein into peripheral blood mononuclear cells, tumor growth can be effectively inhibited without observable toxicity.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Aaron M. Taylor, Jiayi M. Sun, Alexander Yu, Horatiu Voicu, Jianhe Shen, Donald A. Barkauskas, Timothy J. Triche, Julie M. Gastier-Foster, Tsz-Kwong Man, Ching C. Lau
Summary: This study revealed the heterogeneity of osteosarcoma in younger populations and identified several genes, such as IGF1R and FGFR2, that are associated with the pathogenesis of the disease. These genes were found to have a significant impact on the prognosis of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
David S. Shulman, Sonja Chen, David Hall, Anwesha Nag, Aaron R. Thorner, Stephen L. Lessnick, Kimberly Stegmaier, Katherine A. Janeway, Steven G. DuBois, Mark D. Krailo, Donald A. Barkauskas, Alanna J. Church, Brian D. Crompton
Summary: This study aimed to determine the frequency of STAG2 protein loss and its association with the outcome of Ewing sarcoma. The results showed that STAG2 expression loss is common and associated with a poor prognosis in patients without STAG2 mutations. In addition, STAG2 loss in local disease is associated with a decrease in the 5-year event-free survival rate.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Paul Meyers, Emily Slotkin
Summary: This study reviewed the use of irinotecan and temozolomide in patients with recurrent Ewing sarcoma. The results showed that a 10-day irinotecan treatment schedule had a higher objective response rate compared to a 5-day schedule. Therefore, the use of a 10-day irinotecan schedule should be considered in the treatment of recurrent Ewing sarcoma.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Pathology
David J. Ho, Narasimhan P. Agaram, Stephanie D. Suser, Cynthia Chu, Chad M. Vanderbilt, Paul A. Meyers, Leonard H. Wexler, John H. Healey, Thomas J. Fuchs, Meera R. Hameed
Summary: In this study, a deep learning-based approach was proposed to estimate necrosis ratio and predict treatment response and patient outcome in osteosarcoma. The results demonstrate that deep learning can serve as an objective tool for pathologists to analyze histology, assess treatment response, and predict patient prognosis.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
David Milewski, Hyun Jung, G. Thomas Brown, Yanling Liu, Ben Somerville, Curtis Lisle, Marc Ladanyi, Erin R. Rudzinski, Hyoyoung Choo-Wosoba, Donald A. Barkauskas, Tammy Lo, David Hall, Corinne M. Linardic, Jun S. Wei, Hsien-Chao Chou, Stephen X. Skapek, Rajkumar Venkatramani, Peter K. Bode, Seth M. Steinberg, George Zaki, Igor B. Kuznetsov, Douglas S. Hawkins, Jack F. Shern, Jack Collins, Javed Khan
Summary: This study utilized convolutional neural networks (CNN) to predict high-risk mutations and prognosis of rhabdomyosarcoma (RMS) based on histologic features learned from H&E images. The CNN model achieved superior performance in predicting survival and event-free outcomes compared to current molecular-clinical risk stratification methods.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Elysia Alvarez, Jiayi He, Sheri L. Spunt, Andrea Hayes-Jordan, Simon C. Kao, David M. Parham, Lynn Million, Aaron R. Weiss, Donald A. Barkauskas
Summary: The aim of this study is to define the clinical features and outcomes of young patients with NRSTS with LN metastases. LN metastases occur in about 4% of paediatric/young adult NRSTS patients, are limited to a few histologic subtypes, and are rare in patients without clinical or imaging evidence of lymphadenopathy. Therefore, biopsies of non-enlarged LNs are not necessary to identify occult involvement.
EUROPEAN JOURNAL OF CANCER
(2023)
Correction
Medicine, General & Internal
Hannah C. Beird, Stefan S. Bielack, Adrienne M. Flanagan, Jonathan Gill, Dominique Heymann, Katherine A. Janeway, J. Andrew Livingston, Ryan D. Roberts, Sandra J. Strauss, Richard Gorlick
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Medicine, General & Internal
Hannah C. Beird, Stefan S. Bielack, Adrianne M. Flanagan, Jonathan Gill, Dominique Heymann, Katherine A. Janeway, J. Andrew Livingston, Ryan D. Roberts, Sandra J. Strauss, Richard Gorlick
Summary: Osteosarcoma is the most common primary malignant bone tumor with a bimodal incidence peaking at 18 and 60 years of age. It is more common in males and is driven by genetic factors related to bone formation leading to malignant progression and metastasis. Screening is currently focused on high-risk groups, and the prognosis for patients with metastatic disease remains poor.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Biochemistry & Molecular Biology
Jiayi Sun, Wing-Yuk Chow, Gufeng Xu, M. John Hicks, Manjula Nakka, Jianhe Shen, Patrick Kwok Shing M. Ng, Aaron Taylor, Alexander E. Yu, Jason A. Farrar, Donald Barkauskas, Richard M. Gorlick, Jaime M. Guidry Auvil, Daniela Gerhard, Paul Meltzer, Rudy Guerra, Tsz-Kwong C. Man, Ching Lau, TARGET Osteosarcoma Consortium
Summary: Osteosarcoma is a primary malignant bone tumor that commonly metastasizes to the lungs. Altered FAS expression due to DNA methylation has been explored as a mechanism in cancer cells. Analysis revealed high variability in methylation of CpG sites that correlated with FAS mRNA expression. Treatment with demethylating agent 5-azacytidine restored FAS protein expression and reduced metastasis in osteosarcoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Oncology
Paul A. Meyers
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Koichi Ogura, Arielle Elkrief, Anita S. Bowman, Richard P. Koche, Elisa de Stanchina, Ryma Benayed, Audrey Mauguen, Marissa S. Mattar, Inna Khodos, Paul A. Meyers, John H. Healey, William D. Tap, Meera Hameed, Ahmet Zehir, Neerav Shukla, Charles Sawyers, Rohit Bose, Emily Slotkin, Marc Ladanyi
Summary: This study analyzed the cooperating secondary genetic alterations in Ewing sarcoma (ES), identifying recurrent alterations in ERF and FGFR1 genes. Functional studies showed that ERF alterations influenced tumor cell growth, colony formation, and motility, while loss of ERF promoted cellular proliferation and clonogenic growth. The findings provide new insights into ES pathobiology and potential therapeutic approaches for a subset of ES patients.
JCO PRECISION ONCOLOGY
(2022)
Meeting Abstract
Oncology
Bailey A. Martin-Giacalone, Michael E. Scheurer, Javed Khan, Stephen J. Chanock, Shengchao Alfred Li, Meredith Yeager, Deborah A. Marquez-Do, Donald A. Barkauskas, David Hall, Matthew T. McEvoy, Melissa A. Richard, Pagna Sok, Austin L. Brown, Aniko Sabo, Stephen X. Skapek, Douglas S. Hawkins, Rajkumar Venkatramani, Lisa Mirabello, Philip J. Lupo