Integration of Bioinformatics Resources Reveals the Therapeutic Benefits of Gemcitabine and Cell Cycle Intervention in SMAD4-Deleted Pancreatic Ductal Adenocarcinoma

Rapid research autopsy is a stealthy but growing contributor to cancer research

(2019) Eleonora Duregon et al.   CANCER

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

(2019) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

The role of TGF-β/SMAD4 signaling in cancer

(2018) Ming Zhao et al.   International Journal of Biological Sciences

Smad4 Loss Correlates With Higher Rates of Local and Distant Failure in Pancreatic Adenocarcinoma Patients Receiving Adjuvant Chemoradiation

(2018) Joseph M. Herman et al.   PANCREAS

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

(2018) Hervé Tiriac et al.   Cancer Discovery

Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism

(2018) Nikolaos Tsesmetzis et al.   Cancers

New approach for understanding genome variations in KEGG

(2018) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

A comprehensive look of poly(ADP-ribose) polymerase inhibition strategies and future directions for cancer therapy

(2017) Chandan Kumar et al.   Future Medicinal Chemistry

The Impact of SMAD4 Loss on Outcome in Patients with Advanced Pancreatic Cancer Treated with Systemic Chemotherapy

(2017) Steffen Ormanns et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TGF-β in pancreatic cancer initiation and progression: two sides of the same coin

(2017) Wei Shen et al.   Cell and Bioscience

The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance

(2017) Sunjida Ahmed et al.   Journal of Clinical Medicine

TGF-β Tumor Suppression through a Lethal EMT

(2016) Charles J. David et al.   CELL

Mitotic entry: The interplay between Cdk1, Plk1 and Bora

(2016) Alfonso Parrilla et al.   CELL CYCLE

Pancreatic cancer

(2016) Terumi Kamisawa et al.   LANCET

KEGG: new perspectives on genomes, pathways, diseases and drugs

(2016) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

CHK1 Inhibition Synergizes with Gemcitabine Initially by Destabilizing the DNA Replication Apparatus

(2015) S.-B. Koh et al.   CANCER RESEARCH

Gemcitabine resistance in pancreatic ductal adenocarcinoma

(2015) Yoav Binenbaum et al.   DRUG RESISTANCE UPDATES

Insights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-β Signaling

(2015) Paul T. Fullerton et al.   MOLECULAR ENDOCRINOLOGY

Correlating chemical sensitivity and basal gene expression reveals mechanism of action

(2015) Matthew G Rees et al.   Nature Chemical Biology

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset

(2015) B. Seashore-Ludlow et al.   Cancer Discovery

MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4

(2015) Xiang Xia et al.   Oncotarget

Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair

(2015) Tasneem Kausar et al.   NEOPLASIA

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Pancreatic Adenocarcinoma

(2015) David P. Ryan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacological targeting the ATR–CHK1–WEE1 axis involves balancing cell growth stimulation and apoptosis

(2015) Joyce P.Y. Mak et al.   Oncotarget

A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi-1

(2014) Jingnan Wang et al.   Molecular Oncology

Immunohistochemically Detected Expression of 3 Major Genes (CDKN2A/p16, TP53, and SMAD4/DPC4) Strongly Predicts Survival in Patients With Resectable Pancreatic Cancer

(2013) Minoru Oshima et al.   ANNALS OF SURGERY

Failure Patterns in Resected Pancreas Adenocarcinoma

(2013) Jordan M. Winter et al.   ANNALS OF SURGERY

An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules

(2013) Amrita Basu et al.   CELL

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Clinical Significance of the Genetic Landscape of Pancreatic Cancer and Implications for Identification of Potential Long-term Survivors

(2012) S. Yachida et al.   CLINICAL CANCER RESEARCH

Genetically Defined Subsets of Human Pancreatic Cancer Show Unique In Vitro Chemosensitivity

(2012) Y. Cui et al.   CLINICAL CANCER RESEARCH

Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation

(2012) Kenichiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

MicroRNA 421 suppresses DPC4/Smad4 in pancreatic cancer

(2011) Jun Hao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Darinaparsin Is a Multivalent Chemotherapeutic Which Induces Incomplete Stress Response with Disruption of Microtubules and Shh Signaling

(2011) Twila A. Mason et al.   PLoS One

MicroRNA 483-3p suppresses the expression of DPC4/Smad4 in pancreatic cancer

(2010) Jun Hao et al.   FEBS LETTERS

Phenotype and Genotype of Pancreatic Cancer Cell Lines

(2010) Emily L. Deer et al.   PANCREAS

DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer

(2009) Christine A. Iacobuzio-Donahue et al.   JOURNAL OF CLINICAL ONCOLOGY

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

(2009) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

Identification and Characterization of a Novel Anticancer Agent With Selectivity Against Deleted in Pancreatic Cancer Locus 4 (DPC4)-Deficient Pancreatic and Colon Cancer Cells

(2009) Hong Wang et al.   PANCREAS