Trimethylamine N-Oxide Exacerbates Cardiac Fibrosis via Activating the NLRP3 Inflammasome

Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca 2+ /Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling

(2019) Takeshi Suetomi et al.   CIRCULATION

The gut microbiome and elevated cardiovascular risk in obesity and autoimmunity

(2018) Lora J. Kasselman et al.   ATHEROSCLEROSIS

MicroRNA-223 Regulates Cardiac Fibrosis After Myocardial Infarction by Targeting RASA1

(2018) Xiaoxiao Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation

(2018) Chunxia Yao et al.   CIRCULATION

A potential relationship between gut microbes and atrial fibrillation: Trimethylamine N-oxide, a gut microbe-derived metabolite, facilitates the progression of atrial fibrillation

(2018) Lilei Yu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

H3 relaxin inhibits the collagen synthesis via ROS- and P2X7R-mediated NLRP3 inflammasome activation in cardiac fibroblasts under high glucose

(2018) Xiaohui Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ambient fine particulate matter exposure induces reversible cardiac dysfunction and fibrosis in juvenile and older female mice

(2018) Guohua Qin et al.   Particle and Fibre Toxicology

Cardiovascular diseases, NLRP3 inflammasome, and western dietary patterns

(2018) Luis E. Pavillard et al.   PHARMACOLOGICAL RESEARCH

LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d

(2018) Haihai Liang et al.   Theranostics

CHRONIC, LOW-DOSE TMAO TREATMENT REDUCES DIASTOLIC DYSFUNCTION AND HEART FIBROSIS IN HYPERTENSIVE RATS.

(2018) Tomasz Huc et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis

(2018) Zehua Li et al.   LABORATORY INVESTIGATION

Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities

(2018) Nikolaos G. Frangogiannis   MOLECULAR ASPECTS OF MEDICINE

Sulfur dioxide attenuates sepsis-induced cardiac dysfunction via inhibition of NLRP3 inflammasome activation in rats

(2018) Lin Yang et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Gutting TMA to Save the Heart

(2018) Jessica Crothers et al.   Cell Host & Microbe

Interaction between gut microbiome and cardiovascular disease

(2018) Jieting Peng et al.   LIFE SCIENCES

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

(2018) Manuel Janeiro et al.   Nutrients

NLRP3 participates in the regulation of EMT in bleomycin-induced pulmonary fibrosis

(2017) Rui Tian et al.   EXPERIMENTAL CELL RESEARCH

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

(2017) Hadi Khalil et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats

(2017) Zhen Qiu et al.   Oxidative Medicine and Cellular Longevity

Inflammasomes in Liver Fibrosis

(2017) Fernando Alegre et al.   SEMINARS IN LIVER DISEASE

Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria

(2017) Marina Makrecka-Kuka et al.   TOXICOLOGY LETTERS

Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation

(2017) Shaofei Wang et al.   Cell Death & Disease

Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice

(2017) Fu-Li Xiang et al.   Nature Communications

Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta‐Analysis of Prospective Studies

(2017) Yoriko Heianza et al.   Journal of the American Heart Association

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

(2017) Ming‐liang Chen et al.   Journal of the American Heart Association

Trimethylamine N-oxide Supplementation Abolishes the Cardioprotective Effects of Voluntary Exercise in Mice Fed a Western Diet

(2017) Hongqi Zhang et al.   Frontiers in Physiology

Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide Contributes to Cardiac Dysfunction in Western Diet-Induced Obese Mice

(2017) Kui Chen et al.   Frontiers in Physiology

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

Brain-derived neurotrophic factor attenuates doxorubicin-induced cardiac dysfunction through activating Akt signalling in rats

(2016) Pengzhou Hang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Fluorofenidone attenuates pulmonary inflammation and fibrosisviainhibiting the activation of NALP3 inflammasome and IL-1β/IL-1R1/MyD88/NF-κB pathway

(2016) Cheng Song et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Transcriptional control of cardiac fibroblast plasticity

(2016) Janet K. Lighthouse et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection

(2016) Markus Räsänen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans

(2016) Elko Randrianarisoa et al.   Scientific Reports

Suppression of NLRP3 Inflammasome Activation Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis and Diastolic Dysfunction

(2016) Antoinette Bugyei-Twum et al.   Scientific Reports

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart FailureCLINICAL PERSPECTIVE

(2015) Chelsea L. Organ et al.   Circulation-Heart Failure

Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure

(2015) W.H. Wilson Tang et al.   JOURNAL OF CARDIAC FAILURE

Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota

(2015) Chih-Jung Chang et al.   Nature Communications

Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure

(2014) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Gut Feelings About Heart Failure∗

(2014) Jane A. Cannon et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac Fibroblasts Contribute to Myocardial Dysfunction in Mice with Sepsis: The Role of NLRP3 Inflammasome Activation

(2014) Wenbo Zhang et al.   PLoS One

NLRP3 Gene Silencing Ameliorates Diabetic Cardiomyopathy in a Type 2 Diabetes Rat Model

(2014) Beibei Luo et al.   PLoS One

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury

(2013) Øystein Sandanger et al.   CARDIOVASCULAR RESEARCH

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart

(2010) E. E. Creemers et al.   CARDIOVASCULAR RESEARCH