Review
Biochemistry & Molecular Biology
Tohru Kitada, Mustafa T. Ardah, M. Emdadul Haque
Summary: Parkin, discovered 25 years ago as the gene responsible for hereditary Parkinson's disease, remains a subject of intense research interest. Despite extensive efforts, the function and mechanism of the Parkin protein in neuronal cell death and pathogenesis remain unknown. This review highlights the chronological research on the parkin gene and discusses unresolved issues, new trends in research, and the relationship between parkin and tumorigenesis from the perspective of Parkin's redox molecule.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jens O. Watzlawik, Fabienne C. Fiesel, Gabriella Fiorino, Bernardo A. Bustillos, Zahra Baninameh, Briana N. Markham, Xu Hou, Caleb S. Hayes, Jenny M. Bredenberg, Nicholas W. Kurchaba, Dominika Fricova, Joanna Siuda, Zbigniew K. Wszolek, Sachiko Noda, Shigeto Sato, Nobutaka Hattori, Asheeta A. Prasad, Deniz Kirik, Howard S. Fox, Kelly L. Stauch, Matthew S. Goldberg, Wolfdieter Springer
Summary: This study investigates the basal activation levels of the PINK1-PRKN signaling pathway in vivo using rodent samples, patient-derived cells, and isogenic neurons. The findings highlight the age-dependent, brain region-specific, and cell type-specific effects of PINK1-PRKN signaling, which have significant implications for improving diagnosis, prognosis, and patient stratification in Parkinson's disease.
Article
Cell Biology
Fabienne C. Fiesel, Dominika Fricova, Caleb S. Hayes, Mathew A. Coban, Roman Hudec, Jenny M. Bredenberg, Benjamin J. Broadway, Briana N. Markham, Tingxiang Yan, Paige K. Boneski, Gabriella Fiorino, Jens O. Watzlawik, Xu Hou, Arthur M. McCarty, Laura J. Lewis-Tuffin, Jun Zhong, Benjamin J. Madden, Alban Ordureau, Heeseon An, Andreas Puschmann, Zbigniew K. Wszolek, Owen A. Ross, J. Wade Harper, Thomas R. Caulfield, Wolfdieter Springer
Summary: This study investigates the impact of single nucleotide variants in the activation loop of the PINK1 kinase on its enzymatic function. The G411A variant of PINK1 is found to significantly enhance Ub phosphorylation and promote PRKN activation and mitophagy, leading to increased neuronal viability under mitochondrial stress. The mechanism involves the stabilization of PINK1's kinase fold and a change in Ub conformation. These findings suggest that the G411A variant could have therapeutic potential for neuroprotection.
Article
Cell Biology
Jens O. Watzlawik, Xu Hou, Dominika Truban, Chloe Ramnarine, Sandeep K. Barodia, Tania F. Gendron, Michael G. Heckman, Michael DeTure, Joanna Siuda, Zbigniew K. Wszolek, Clemens R. Scherzer, Owen A. Ross, Guojun Bu, Dennis W. Dickson, Matthew S. Goldberg, Fabienne C. Fiesel, Wolfdieter Springer
Summary: Mitochondrial dysfunction is an early event in neurodegenerative disorders like Parkinson's and Alzheimer's disease. Researchers developed a sensitive ELISA tool to measure mitophagy levels and found that the PINK1-PRKN mitophagy pathway is actively involved in both mice and humans under various physiological and pathological conditions.
Article
Cell Biology
Zhengying Yu, Haipeng Wang, Wanyi Tang, Shaoyang Wang, Xiaoying Tian, Yujie Zhu, Hao He
Summary: A new optical method, UPLaS, has been developed to precisely and noninvasively induce localized mitochondrial Ca2+ oscillations, which directly initiates the PINK1-Parkin pathway for mitophagy.
CELL DEATH & DISEASE
(2021)
Review
Cell Biology
Augoustos Tsamourgelis, Peter Swann, Leonidas Chouliaras, John T. O'Brien
Summary: Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia. Proteomics has revealed protein dysregulation in the brain and peripheral tissues in DLB, which shares common features with other dementias but also has unique protein signatures. Identifying novel protein targets and diagnostic biomarkers could lead to new therapeutics and improved clinical trials for DLB.
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Jannik Prasuhn, Meike Kasten, Melissa Vos, Inke R. Koenig, Sebastian M. Schmid, Britta Wilms, Christine Klein, Norbert Brueggemann
Summary: This study aims to investigate the potential effects of vitamin K2 on genetically determined Parkinson's disease patients, using advanced neuroimaging methods and biomarker sampling. Patients are selected based on mutation-related mitochondrial dysfunction in a personalized medicine approach and the study will explore the predictive ability of neuroimaging and blood-derived biomarkers on individual treatment response in sporadic PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Dajana Grossmann, Nina Malburg, Hannes Glass, Veronika Weeren, Verena Sondermann, Julia F. F. Pfeiffer, Janine Petters, Jan Lukas, Philip Seibler, Christine Klein, Anne Gruenewald, Andreas Hermann
Summary: Recent studies have shown that PINK1 and Parkin play a crucial role in mitochondrial calcium homeostasis and regulation of MERCSs. Using iPSC-derived dopaminergic neurons, researchers found that deficiency in PINK1 or PRKN affects MERCSs dynamics and composition, leading to impaired calcium homeostasis. These findings provide insights into the pathogenesis of PINK1/Parkin-related Parkinson's disease.
MOVEMENT DISORDERS
(2023)
Article
Cell Biology
Benjamin J. Broadway, Paige K. Boneski, Jenny M. Bredenberg, Ana Kolicheski, Xu Hou, Alexandra Soto-Beasley, Owen A. Ross, Wolfdieter Springer, Fabienne C. Fiesel
Summary: Loss of PINK1 or PRKN can cause early onset Parkinson's disease. Through analyzing a set of variants, this study identifies specific rare genetic PINK1 and PRKN variants that result in loss of enzymatic function and suggests their potential causative role in Parkinson's disease. Additionally, the study finds intermediate phenotypes in several variants and investigates the functional deficits of two variants using gene editing. The findings of this study contribute to the diagnostics and treatment of Parkinson's disease.
Article
Biochemistry & Molecular Biology
Esha Sircar, Sristi Raj Rai, Mark A. Wilson, Michael G. Schlossmacher, Rajib Sengupta
Summary: Parkinson's disease is a rapidly growing neurodegenerative disorder with a strong genetic component. Aberrant S-nitrosylation of proteins like Parkin, DJ-1, and PINK1 may contribute to the pathogenesis of PD, emphasizing the importance of this post-translational modification in neuronal health.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Cell Biology
Daniel Aghaie Madsen, Sissel Ida Schmidt, Morten Blaabjerg, Morten Meyer
Summary: This review article examines the role of Parkin and alpha-synuclein in the pathophysiology of Parkinson's disease, particularly focusing on the PARK2 gene mutations causing early-onset PD and the interaction between parkin and alpha-synuclein in protein aggregation regulation. The study provides insights into the potential formation of intracellular micro-aggregates in PARK2-related PD, suggesting new avenues for research into primary signaling processes involved in PD and related neurodegenerative disorders.
Review
Physiology
Mohamed A. Eldeeb, Rhalena A. Thomas, Mohamed A. Ragheb, Armaan Fallahi, Edward A. Fon
Summary: Mitochondria, as a central hub for cellular metabolism and signaling, play a crucial role in human diseases. Eukaryotic cells have developed sophisticated quality control mechanisms to monitor and repair/mitophagy abnormal proteins and dysfunctional mitochondria. Chaperones help refold unstable proteins, which are selectively degraded if repair is not possible. Autophagy-lysosomal and ubiquitin-proteasome systems mediate the degradation of abnormal proteins. Mitophagy is responsible for eliminating dysfunctional mitochondria to protect cells from damage.
PHYSIOLOGICAL REVIEWS
(2022)
Review
Neurosciences
Iryna Kamienieva, Jerzy Duszynski, Joanna Szczepanowska
Summary: The familial form of Parkinson's disease is linked to mutations in specific genes, with mutations in the parkin gene being one of the most common causes of early-onset PD. Mitochondrial dysfunction is an emerging active player in the pathology of neurodegenerative diseases, as mitochondria are highly dynamic structures integrated with many cellular functions.
TRANSLATIONAL NEURODEGENERATION
(2021)
Editorial Material
Cell Biology
Zak Doric, Huihui Li, Ken Nakamura
Summary: This study summarizes recent findings enabled by a new platform for tracking individual mitochondria in neurons, outlining the steps of PINK1- and PRKN-dependent mitochondrial turnover, including the unexplored fates of mitochondria after fusion with lysosomes. These studies reveal unexpected mechanisms of mitochondrial quality control, which may contribute to the reliance of neurons on PINK1 under stress conditions.
Review
Cell Biology
Xiaofeng Zhang, Jing Feng, Xia Li, Dan Wu, Qian Wang, Shuyu Li, Changhua Shi
Summary: This review provides compelling evidence for the important role of mitophagy in DKD and offers new insights into potential therapeutic approaches for maintaining homeostasis in the glomeruli and tubules.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Jin Ho Jung, Yae Ji Kim, Seok Jong Chung, Han Soo Yoo, Yang Hyun Lee, Kyoungwon Baik, Seong Ho Jeong, Young Gun Lee, Hye Sun Lee, Byoung Seok Ye, Young H. Sohn, Yong Jeong, Phil Hyu Lee
Summary: The study aimed to investigate the role of white matter connectivity networks in the development of levodopa-induced dyskinesia, and comparative analysis between vulnerable and resistant groups revealed lower mean diffusivity in the left frontal region of the vulnerable group. Furthermore, the study found stronger connectivity within subnetwork A and hub-subnetwork centered on the left superior frontal gyrus in the vulnerable group, which were associated with the development of levodopa-induced dyskinesia.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Seok Jong Chung, Yae Ji Kim, Jin Ho Jung, Hye Sun Lee, Byoung Seok Ye, Young H. Sohn, Yong Jeong, Phil Hyu Lee
Summary: This study demonstrates that disrupted white matter connectivity in the frontal and posterior cortical regions is associated with early dementia conversion in patients with newly diagnosed Parkinson's disease with mild cognitive impairment (PD-MCI).
Article
Clinical Neurology
Han Soo Yoo, Seun Jeon, Enrica Cavedo, MinJin Ko, Mijin Yun, Phil Hyu Lee, Young H. Sohn, Michel J. Grothe, Stefan Teipel, Harald Hampel, Alan C. Evans, Byoung Seok Ye
Summary: The relationship between cholinergic degeneration, beta-amyloid, brain atrophy, and cognitive dysfunction in Alzheimer disease (AD) and Lewy body disease (LBD) was comparatively evaluated. The results showed a common mechanism of beta-amyloid-related degeneration with or without the mediation of basal forebrain. However, the association of basal forebrain atrophy with cognitive dysfunction was more profound in LBD, where there was also localized beta-amyloid-cortical atrophy interaction.
Article
Geriatrics & Gerontology
Sakulrat Mankhong, Sujin Kim, Sohee Moon, Seong-Hye Choi, Hyo-Bum Kwak, Dong-Ho Park, Pratik Shah, Phil Hyu Lee, Seong Wook Yang, Ju-Hee Kang
Summary: This study discovered differentially expressed blood miRNAs in Korean AD patients and investigated their role in amyloidogenesis. However, the diagnostic utility of these miRNAs as biomarkers was limited.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Neurosciences
Sooyeon Ji, Eun-Jung Choi, Beomseok Sohn, Kyoungwon Baik, Na-Young Shin, Won-Jin Moon, Seongbeom Park, Soohwa Song, Phil Hyu Lee, Dong Hoon Shin, Se-Hong Oh, Eung Yeop Kim, Jongho Lee
Summary: This study proposes a new NM-sensitive imaging method called sandwichNM, which utilizes the incidental MT effects of spatial saturation RF pulses to generate high-quality NM images using product sequences. Compared to conventional NM-sensitive imaging methods, sandwichNM provides higher NM contrast and consistent contrasts across vendors in a multi-vendor experiment.
Article
Clinical Neurology
Seong Ho Jeong, Jungho Cha, Mincheol Park, Jin Ho Jung, Byoung Seok Ye, Young H. Sohn, Seok Jong Chung, Phil Hyu Lee
Summary: This study investigated the effects of enlarged perivascular space (EPVS) on amyloid burden and cognitive function in Alzheimer's disease (AD) continuum. The results showed that BG-EPVS, CSO-EPVS, and HP-EPVS were not associated with baseline amyloid burden or cognitive function in AD continuum. However, CSO-EPVS appeared to be associated with the progression of cognitive decline independently of amyloid burden.
Article
Clinical Neurology
Seok Jong Chung, Yae Ji Kim, Yun Joong Kim, Hye Sun Lee, Seong Ho Jeong, Ji-Man Hong, Young H. Sohn, Mijin Yun, Yong Jeong, Phil Hyu Lee
Summary: Different patterns of striatal dopamine depletion are closely associated with WM structural alterations, which may contribute to heterogeneous cognitive profiles in individuals with PD.
Article
Clinical Neurology
Yae Ji Kim, Chan Wook Park, Hye Won Shin, Hye Sun Lee, Yun Joong Kim, Mijin Yun, Phil Hyu Lee, Young H. Sohn, Yong Jeong, Seok Jong Chung
Summary: This study explored the white matter structural network associated with motor reserve in patients with newly diagnosed Parkinson's disease (PD). It found that higher network strength was associated with a slower longitudinal increase in levodopa-equivalent dose (LED) during a 3-year follow-up period.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Seong Ho Jeong, Hye Sun Lee, Phil Hyu Lee, Young H. Sohn, Seok Jong Chung
Summary: The study investigates the influence of nigrostriatal dopaminergic degeneration on longitudinal outcomes in Parkinson's disease (PD) according to sex. It reveals that there are differences in the severity of dopamine transporter (DAT) availability and the risk of developing levodopa-induced dyskinesia (LID) and PD dementia (PDD) between male and female PD patients.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Cell & Tissue Engineering
Jin Young Shin, Dong-Yeol Kim, Jieun Lee, Yu Jin Shin, Yi Seul Kim, Phil Hyu Lee
Summary: Priming MSCs with alpha-syn enhances stemness properties and modulates autophagy-related gene expression profiles, suggesting a potential neuroprotective effect in Parkinsonian models.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Seok Jong Chung, Yae Ji Kim, Yun Joong Kim, Hye Sun Lee, Mijin Yun, Phil Hyu Lee, Yong Jeong, Young H. Sohn
Summary: This study found a link between cognitive function and motor reserve in patients with newly diagnosed Parkinson's disease. The motor reserve estimate was correlated with verbal memory function and white matter integrity in the left fornix.
JOURNAL OF MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Seong Ho Jeong, Chan Wook Park, Hye Sun Lee, Yun Joong Kim, Mijin Yun, Phil Hyu Lee, Young H. Sohn, Seok Jong Chung
Summary: The study investigated whether different patterns of striatal dopamine depletion are associated with motor deficits in Parkinson's disease. A total of 404 drug-naive patients with early-stage PD were enrolled and underwent dopamine transporter imaging. Principal component analysis identified three patterns of dopamine depletion: overall deficiency, selective loss in the sensorimotor striatum, and symmetric loss in the striatum. Linear regression analysis revealed that overall deficiency and selective loss were associated with motor deficits, while symmetric loss was not. Mediation analysis showed that dopamine deficiency in the posterior putamen mediated the association between dopamine depletion patterns and motor deficits. These findings suggest that dopamine deficiency in the posterior putamen plays a crucial role in motor deficits in PD.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Review
Clinical Neurology
Jin Yong Hong, Phil Hyu Lee
Summary: Subjective cognitive complaints (SCCs), self-perceived cognitive decline, are related to objective cognitive decline. SCCs in cognitively normal individuals serve as a preclinical sign of subsequent cognitive impairment due to Alzheimer's disease. This review highlights the current research on SCCs in cognitively normal patients with Parkinson's disease, emphasizing the need for coherence in defining and assessing SCCs, and the value of SCCs in predicting cognitive decline. It also calls for further biomarker studies to establish the underlying pathological basis for these findings.
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Seong Ho Jeong, Jungho Cha, Jin Ho Jung, Mijin Yun, Young H. Sohn, Seok Jong Chung, Phil Hyu Lee
Summary: This study found that additional occipital amyloid-beta deposition is associated with poor baseline language function and rapid cognitive deterioration in patients with Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Kyoungwon Baik, Seun Jeon, Mincheol Park, Young-gun Lee, Phil Hyu Lee, Young H. Sohn, Byoung Seok Ye
Summary: This study compared the imaging characteristics and cutoff value of 18F-florapronol (FC119S) and 18F-florbetaben (FBB) positron emission tomography (PET) in detecting 3-amyloid positivity and Alzheimer's disease (AD) in patients with cognitive impairment. The findings showed that quantitative FC119S-PET analysis provided reliable information for detecting 3-amyloid deposition and the presence of AD.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)