Article
Biochemistry & Molecular Biology
Valerie Perea, Christian Cole, Justine Lebeau, Vivian Dolina, Kelsey R. Baron, Aparajita Madhavan, Jeffery W. Kelly, Danielle A. Grotjahn, R. Luke Wiseman
Summary: Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are interconnected in the development of various diseases. The PERK signaling pathway, an arm of the unfolded protein response (UPR), plays a significant role in regulating mitochondrial biology during ER stress. This study reveals that PERK activity promotes adaptive remodeling of mitochondrial membrane phosphatidic acid (PA), leading to protective mitochondrial elongation in response to acute ER stress. These findings highlight a novel role for PERK in modulating mitochondrial phospholipids and demonstrate its involvement in adapting organellar shape during ER stress.
Article
Parasitology
Cudjoe Obed, Minmin Wu, Ying Chen, Ran An, Haijian Cai, Qingli Luo, Li Yu, Jie Wang, Fang Liu, Jilong Shen, Jian Du
Summary: Toxoplasma infection can cause ER stress and apoptosis in host cells. The dense granule protein GRA3 plays a role in the virulence of T. gondii, and it induces neural cell apoptosis via the ER stress signaling pathway.
PARASITES & VECTORS
(2022)
Article
Multidisciplinary Sciences
Gunes Parlakgul, Ana Paula Arruda, Song Pang, Erika Cagampan, Nina Min, Ekin Guney, Grace Yankun Lee, Karen Inouye, Harald F. Hess, C. Shan Xu, Gokhan S. Hotamisligil
Summary: This study reveals the complex structural organization of organelles in liver tissue and highlights the significant alterations in obese mice. The functional importance of these structural changes on cellular and systemic metabolism is also demonstrated.
Article
Biochemistry & Molecular Biology
Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Dong
Summary: The aim of this study was to investigate the protective mechanism of geraniol against cerebral ischemia-reperfusion injury (CIRI). The results showed that geraniol effectively attenuated cerebral infarction and pathological injury, reduced ER-stress-related protein expression and apoptosis occurrence, and increased anti-apoptotic protein expression, suggesting a protective effect against CIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Lingai Pan, Dongke Yu, Yuan Zhang, Changyu Zhu, Qinan Yin, Yu Hu, Xiaoqin Zhang, Ruiming Yue, Xuan Xiong
Summary: The study shows that PS microplastics can induce ER stress in the liver, leading to apoptosis and oxidative stress in hepatocytes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Neurosciences
Zahara L. Chaudhry, Mahmoud Gamal, Ingrid Ferhati, Mohamad Warda, Bushra Y. Ahmed
Summary: The outbreak of COVID-19 caused by SARS-CoV-2 is a major global public health concern. This study investigates the relationship between SARS-CoV-2 infection and Parkinson's disease (PD), both of which involve oxidative stress and endoplasmic reticulum (ER) stress. The study explores the influence of the PERK stress pathway in SARS-CoV-2 infection and PD, and examines the potential of ER stress inhibitors to provide cellular protection. The findings suggest that targeting ER stress may offer therapeutic approaches for treating COVID-19 and PD.
Article
Medicine, Research & Experimental
Zhenyan He, Linh Lieu, Yanbin Dong, Sadia Afrin, Dominic Chau, Anita Kabahizi, Briana Wallace, Jianhong Cao, Eun-Sang Hwang, Ting Yao, Yiru Huang, Jennifer Okolo, Bo Cheng, Yong Gao, Ling Hu, Kevin W. Williams
Summary: The study showed that PERK deficiency in POMC neurons in male mice may protect against diet-induced obesity, while attenuating the improvements in leptin sensitivity and energy balance induced by celastrol.
Article
Ophthalmology
Shuizhen Shi, Chun Ding, Shuang Zhu, Fan Xia, Seth E. Buscho, Shengguo Li, Massoud Motamedi, Hua Liu, Wenbo Zhang
Summary: In this study, the role of PERK in ischemia-induced retinopathy was investigated using a mouse model of oxygen-induced retinopathy (OIR). The results showed that inhibition of PERK reduced retinal neovascularization and retinal ganglion cell loss, restored astrocyte network, and promoted revascularization. Therefore, PERK inhibition may provide an effective therapeutic intervention for alleviating retinal neovascularization and preventing neuron loss during retinal ischemia.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Immunology
Changqin Song, Jiaxi Chen, Xiaotian Li, Runyu Yang, Xiaomei Cao, Lvqi Zhou, Yanfen Zhou, Hanjie Ying, Qi Zhang, Yang Sun
Summary: Limonin mitigates DSS-induced chronic colitis by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-kappa B signaling, showing potential as an effective drug for IBD in the future.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Lili Wu, Chunfeng Liang, Xuemei Huang, Xiujun Deng, Jiming Jiang, Zuojie Luo
Summary: The study found that Sal inhibits migration and proliferation of ACC cells, increases the influx of Ca2+ ions, and promotes apoptosis. Sal treatment upregulated the expression of PERK/eIF2 alpha/ATF4 signaling-related proteins and apoptosis-related proteins. Sal reduces cell viability, increases intracellular calcium concentration, and promotes ACC cell apoptosis by activating the PERK/eIF2 alpha/ATF4 signaling pathway.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Cell Biology
Dan Zhang, Yutong Liu, Yezhang Zhu, Qian Zhang, Hongxing Guan, Shengduo Liu, Shasha Chen, Chen Mei, Chen Chen, Zhiyong Liao, Ying Xi, Songying Ouyang, Xin-Hua Feng, Tingbo Liang, Li Shen, Pinglong Xu
Summary: The non-canonical cGAS-STING pathway, involving the activation of PERK-eIF2 alpha, contributes to mRNA translation and plays a role in cellular senescence and fibrosis. This finding sheds light on the connection between DNA sensing and cellular physiology, and suggests the therapeutic potential of targeting the STING-PERK pathway in fibrotic diseases.
NATURE CELL BIOLOGY
(2022)
Article
Immunology
Mingyu Liu, Chong Wu, Shufeng Luo, Qiaomin Hua, Hai-Tian Chen, Yulan Weng, Junyu Xu, Huiling Lin, Lu Wang, Jinheng Li, Lan Zhu, Zhenhong Guo, Shi-Mei Zhuang, Tiebang Kang, Limin Zheng
Summary: The study reveals that PKR-like endoplasmic reticulum kinase (PERK) plays a crucial role in hematopoietic stem/progenitor cell (HSPC) preconditioning and the generation of tumor-promoting myeloid cells in the spleen. Inhibiting PERK signaling pathway prevents HSPCs from becoming MDSCs, providing a potential therapeutic opportunity for restraining the tumor-promoting myeloid response.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Yafeng Gao, Wenhui Li, Zhenghao Wang, Cangang Zhang, Yaping He, Xiaowei Liu, Kexin Tang, Weiguo Zhang, Qiaoming Long, Yong Liu, Jinping Zhang, Baojun Zhang, Lianjun Zhang
Summary: Studies have shown that SEL1L deficiency leads to reduced frequency and number of peripheral T cells, especially naive CD8(+) T cells. SEL1L deficiency also results in activation of mTORC1/c-MYC and metabolic shift, as well as excessive endoplasmic reticulum stress. These findings suggest that SEL1L plays an important role in preserving the survival and homeostasis of peripheral T cells.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Neurosciences
Katarzyna Mnich, Shirin Moghaddam, Patrick Browne, Timothy Counihan, Stephen P. Fitzgerald, Kenneth Martin, Ciaran Richardson, Afshin Samali, Adrienne M. Gorman
Summary: ER stress-regulated proteins in blood may serve as diagnostic biomarkers for Parkinson's disease (PD).
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Atsushi Yukimoto, Takao Watanabe, Kotaro Sunago, Yoshiko Nakamura, Takaaki Tanaka, Yohei Koizumi, Osamu Yoshida, Yoshio Tokumoto, Masashi Hirooka, Masanori Abe, Yoichi Hiasa
Summary: The study uncovers the close relationship between PERK and RMRP in HCC, with downregulation of RMRP inducing apoptotic cell death. This suggests RMRP could be a potential new therapeutic target for regulating HCC in patients with chronic liver diseases associated with ER stress.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Carmine Izzo, Valeria Visco, Jessica Gambardella, Germano Junior Ferruzzi, Antonella Rispoli, Maria Rosaria Rusciano, Anna Laura Toni, Nicola Virtuoso, Albino Carrizzo, Paola Di Pietro, Guido Iaccarino, Carmine Vecchione, Michele Ciccarelli
Summary: The COVID-19 pandemic caused by SARS-CoV-2 is a global challenge, with cardiovascular involvement being a crucial complication. This report discusses the role of microRNAs in cardiovascular complications associated with COVID-19, highlighting their potential as biomarkers and predictors of cardiac and vascular damage.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Angela Corvino, Elisa Magli, Massimiliano Minale, Andrea Autelitano, Valeria Valente, Giovanna Maria Pierantoni
Summary: This study evaluated the pharmacokinetics and effectiveness of oral and parenteral preparations based on phloroglucinol in reducing pain and spasms associated with urinary and biliary colic. The results showed that phloroglucinol is as effective as current therapeutic options in treating pain and spasms associated with these conditions.
ADVANCES IN THERAPY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Albino Carrizzo, Concetta Iside, Angela Nebbioso, Vincenzo Carafa, Antonio Damato, Michele Ciccarelli, Eleonora Venturini, Paola Di Pietro, Bruno Trimarco, Carmine Selleri, Lucia Altucci, Carmine Vecchione
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Article
Biochemistry & Molecular Biology
Riccardo Turchi, Flavia Tortolici, Monica Benvenuto, Carolina Punziano, Anastasia De Luca, Stefano Rufini, Raffaella Faraonio, Roberto Bei, Daniele Lettieri-Barbato, Katia Aquilano
Summary: Cancer cells can resist stress signals and change their metabolism to support their rapid growth. Targeting their nutrient dependencies may be an effective anti-cancer strategy. We investigated the effect of modifying nutrient availability on breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Nunzia Mollo, Roberta Scognamiglio, Anna Conti, Simona Paladino, Lucio Nitsch, Antonella Izzo
Summary: Down syndrome (DS), caused by trisomy of chromosome 21 (Hsa21), is a major cause of congenital heart defects (CHD). The overexpression of Hsa21 genes likely contributes to CHD, along with genes on other chromosomes, miRNAs, and lncRNAs. ECM plays a key role in cardiac morphogenesis, with many ECM genes overexpressed in trisomic fetal hearts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Paola Di Pietro, Carmine Izzo, Angela Carmelita Abate, Paola Iesu, Maria Rosaria Rusciano, Eleonora Venturini, Valeria Visco, Eduardo Sommella, Michele Ciccarelli, Albino Carrizzo, Carmine Vecchione
Summary: Cardiovascular diseases (CVDs) are the leading cause of death and illness worldwide, accounting for 47% of deaths in Europe. Bioactive sphingolipids, including ceramides and sphingosine-1-phosphate (S1P), have been identified as drivers of CVDs. Monitoring sphingolipid levels could provide insights into the progression and severity of cardiovascular diseases and may be a potential target for therapeutic intervention.
Article
Clinical Neurology
A. Scaravilli, M. Tranfa, G. Pontillo, F. Falco, C. Criscuolo, M. Moccia, S. Monti, R. Lanzillo, V. Brescia Morra, G. Palma, M. Petracca, E. Tedeschi, A. Elefante, A. Brunetti, S. Cocozza
Summary: This study aimed to evaluate the long-term impact of gadolinium retention in the dentate nuclei on motor and cognitive disability in patients with MS. The findings showed no significant association between gadolinium retention and long-term motor or cognitive outcomes in these patients.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
F. Sardina, A. Conte, S. Paladino, G. M. Pierantoni, C. Rinaldo
Summary: HIPK2 is an evolutionary conserved serine/threonine kinase with multifunctional roles in stress response, embryonic development, and pathological conditions. It modulates multiple signaling pathways and regulates cell fate and proliferation. HIPK2 is highly expressed in the nervous systems and is involved in neurological disorders, making it a potential therapeutic target and diagnostic or prognostic marker.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
R. Bonavita, G. Scerra, R. Di Martino, S. Nuzzo, E. Polishchuk, M. Di Gennaro, S. Williams, M. G. Caporaso, C. Caiazza, R. Polishchuk, M. D'Agostino, A. Fleming, M. Renna
Summary: Conformational diseases, such as Alzheimer's, Parkinson's, and Huntington's diseases, involve the aggregation and accumulation of proteins with abnormal conformations. Recent evidence suggests that the pathogenesis of these diseases may involve the transcellular transfer of mutated proteins. A novel role for the HSPB1-p62/SQSTM1 complex has been discovered, showing that it allows the unconventional secretion of mutant HTT through extracellular vesicles. This finding provides a new understanding of the mechanisms underlying Huntington's disease and may have implications for the treatment of other aggregation-prone proteins.
HUMAN MOLECULAR GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Giuliana La Rosa, Maria Serena Lonardo, Nunzia Cacciapuoti, Espedita Muscariello, Bruna Guida, Raffaella Faraonio, Mariarosaria Santillo, Simona Damiano
Summary: Multiple sclerosis (MS) is a complex immune-mediated disease caused by gene-environment interactions. Dietary factors, particularly polyphenols, modulate inflammation and gut microbiota, making them potential adjuvant therapies for MS. This review explores the protective effects of polyphenols, such as resveratrol and curcumin, in MS through in vitro and animal studies. Clinical evidence is limited, but studies on substances like curcumin and epigallocatechin gallate show promise. Additionally, a clinical trial investigating the effects of polyphenols in MS patients is discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Alfonso Campanile, Valeria Visco, Stefania De Carlo, Germano Junior Ferruzzi, Costantino Mancusi, Carmine Izzo, Felice Mongiello, Paola Di Pietro, Nicola Virtuoso, Amelia Ravera, Domenico Bonadies, Carmine Vecchione, Michele Ciccarelli
Summary: This study compares the effects of Sac/Val and standard medical therapy on prognostically significant CPET parameters in HFrEF patients. After a median follow-up of 16 months, no significant differences were observed in peak VO2 and other CPET measures between Sac/Val and standard therapy.
Review
Cardiac & Cardiovascular Systems
Valeria Visco, Carmine Izzo, Costantino Mancusi, Antonella Rispoli, Michele Tedeschi, Nicola Virtuoso, Angelo Giano, Renato Gioia, Americo Melfi, Bianca Serio, Maria Rosaria Rusciano, Paola Di Pietro, Alessia Bramanti, Gennaro Galasso, Gianni D'Angelo, Albino Carrizzo, Carmine Vecchione, Michele Ciccarelli
Summary: Arterial hypertension is a growing concern with the increasing aging population, and the potential of artificial intelligence in its prevention and treatment is well recognized. This article reviews the benefits of AI in managing hypertension, including personalized medicine and tailored treatment. However, the limitations and technical issues, such as biases and data privacy, should also be considered.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Editorial Material
Clinical Neurology
Roberto Erro, Marina Picillo, Maria Teresa Pellecchia, Paolo Barone
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Cell Biology
Dandan Liu, Simona Paladino, Chiara Zurzolo, Stephanie Lebreton
Summary: Protein secretion is crucial for maintaining the balance of epithelial tissue and needs to be tightly regulated. Recent studies have shown that the calcium manganese pump SPCA1 and calcium-binding protein Cab45 play a role in regulating the secretion of certain soluble cargoes in nonpolarized cells. Our research focuses on the mechanism governing the polarized secretion of soluble cargoes in polarized epithelial cells, highlighting the critical role of a calcium-dependent Cab45 mechanism in regulating apical exocytosis.
MOLECULAR BIOLOGY OF THE CELL
(2023)
Review
Cardiac & Cardiovascular Systems
Valeria Visco, Carmine Izzo, Davide Bonadies, Federica Di Feo, Giuseppe Caliendo, Francesco Loria, Costantino Mancusi, Pierpaolo Chivasso, Paola Di Pietro, Nicola Virtuoso, Albino Carrizzo, Carmine Vecchione, Michele Ciccarelli
Summary: Obesity is a global public health problem that is linked to lower life expectancy and increased cardiovascular risk. In addition to direct effects, obesity can indirectly contribute to cardiovascular disease through associated comorbidities. While diet and physical activity are important for preventing cardiovascular disease, other interventions like medication and surgery may be needed. This review examines various interventions for addressing cardiovascular risk in obese patients and emphasizes the importance of adherence to treatment.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)