Integrated transcriptomics reveals master regulators of lung adenocarcinoma and novel repositioning of drug candidates

The Human Transcription Factors

(2018) Samuel A. Lambert et al.   CELL

FOXM1 regulates radiosensitivity of lung cancer cell partly by upregulating KIF20A

(2018) Guanghong Xiu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hypoxic-stabilized EPAS1 proteins transactivate DNMT1 and cause promoter hypermethylation and transcription inhibition of EPAS1 in non-small cell lung cancer

(2018) Xiang-Hong Xu et al.   FASEB JOURNAL

HOXA4, down-regulated in lung cancer, inhibits the growth, motility and invasion of lung cancer cells

(2018) Shaofei Cheng et al.   Cell Death & Disease

Targeting the SET and RING-associated (SRA) domain of ubiquitin-like, PHD and ring finger–containing 1 (UHRF1) for anti-cancer drug development

(2018) Debasis Patnaik et al.   Oncotarget

Master Regulators Connectivity Map: A Transcription Factors-Centered Approach to Drug Repositioning

(2018) Marco A. De Bastiani et al.   Frontiers in Pharmacology

Multi-Omics Analysis Reveals a HIF Network and Hub Gene EPAS1 Associated with Lung Adenocarcinoma

(2018) Zhaoxi Wang et al.   EBioMedicine

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

HOXA4-regulated miR-138 suppresses proliferation and gefitinib resistance in non-small cell lung cancer

(2018) Xiaomei Tang et al.   MOLECULAR GENETICS AND GENOMICS

Expression and prognosis analyses of forkhead box A (FOXA) family in human lung cancer

(2018) Chaoqun Huang et al.   GENE

Transcription factor Etv5 is essential for the maintenance of alveolar type II cells

(2017) Zhen Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UHRF1: The key regulator of epigenetics and molecular target for cancer therapeutics

(2017) Harsimran Sidhu et al.   TUMOR BIOLOGY

TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment

(2017) Michael W. Pickup et al.   Cold Spring Harbor Perspectives in Biology

DACH1 inhibits the proliferation and invasion of lung adenocarcinoma through the downregulation of peroxiredoxin 3

(2016) Ji Zhu et al.   TUMOR BIOLOGY

Molecular gene signature and prognosis of non-small cell lung cancer

(2016) Poyin Huang et al.   Oncotarget

Downregulation of ATOH8 induced by EBV-encoded LMP1 contributes to the malignant phenotype of nasopharyngeal carcinoma

(2016) Zifeng Wang et al.   Oncotarget

The retinal determination gene network: from developmental regulator to cancer therapeutic target

(2016) Deguang Kong et al.   Oncotarget

A Systematic Framework for Drug Repositioning from Integrated Omics and Drug Phenotype Profiles Using Pathway-Drug Network

(2016) Erkhembayar Jadamba et al.   Biomed Research International

Smad6 determines BMP-regulated invasive behaviour of breast cancer cells in a zebrafish xenograft model

(2016) Miriam de Boeck et al.   Scientific Reports

Iron chelators target both proliferating and quiescent cancer cells

(2016) Mårten Fryknäs et al.   Scientific Reports

PharmacoGx: an R package for analysis of large pharmacogenomic datasets

(2015) Petr Smirnov et al.   BIOINFORMATICS

Hox genes, evo-devo, and the case of the ftz gene

(2015) Leslie Pick   CHROMOSOMA

Prognostic Value of FOXM1 in Patients with Malignant Solid Tumor: A Meta-Analysis and System Review

(2015) Jun Dai et al.   DISEASE MARKERS

Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells

(2015) Yangyang Song et al.   GASTROENTEROLOGY

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis

(2015) Carman Man-Chung Li et al.   GENES & DEVELOPMENT

The DACH/EYA/SIX gene network and its role in tumor initiation and progression

(2015) Yu Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Regulators of genetic risk of breast cancer identified by integrative network analysis

(2015) Mauro A A Castro et al.   NATURE GENETICS

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

LPP inhibits collective cell migration during lung cancer dissemination

(2015) S Kuriyama et al.   ONCOGENE

Genome Wide Methylome Alterations in Lung Cancer

(2015) Nandita Mullapudi et al.   PLoS One

The rise of systems pharmacology in drug discovery and development

(2014) Neil Benson et al.   Future Medicinal Chemistry

Stability Indicators in Network Reconstruction

(2014) Michele Filosi et al.   PLoS One

Functional Module Connectivity Map (FMCM): A Framework for Searching Repurposed Drug Compounds for Systems Treatment of Cancer and an Application to Colorectal Adenocarcinoma

(2014) Feng-Hsiang Chung et al.   PLoS One

Differential network analysis for the identification of condition-specific pathway activity and regulation

(2013) Gennaro Gambardella et al.   BIOINFORMATICS

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Dachshund Binds p53 to Block the Growth of Lung Adenocarcinoma Cells

(2013) K. Chen et al.   CANCER RESEARCH

Targeting transcription factors

(2013) Jennifer E. Yeh et al.   CURRENT OPINION IN ONCOLOGY

Nkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma

(2013) Eric L. Snyder et al.   MOLECULAR CELL

Analysis Tool Web Services from the EMBL-EBI

(2013) Hamish McWilliam et al.   NUCLEIC ACIDS RESEARCH

Screening for transcription factors and their regulatory small molecules involved in regulating the functions of CL1-5 cancer cells under the effects of macrophage-conditioned medium

(2013) DONGBO XUE et al.   ONCOLOGY REPORTS

A worldwide trend of increasing primary adenocarcinoma of the lung

(2013) Haruhiko Nakamura et al.   SURGERY TODAY

Master regulators of FGFR2 signalling and breast cancer risk

(2013) Michael N. C. Fletcher et al.   Nature Communications

Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

(2012) Daniel Nagel et al.   CANCER CELL

Methotrexate: a detailed review on drug delivery and clinical aspects

(2012) Zulfequar Ahamad Khan et al.   Expert Opinion on Drug Delivery

Association of lung adenocarcinoma clinical stage with gene expression pattern in noninvolved lung tissue

(2012) Elisa Frullanti et al.   INTERNATIONAL JOURNAL OF CANCER

Frequent downregulation of the transcription factor Foxa2 in lung cancer through epigenetic silencing

(2012) Daniela S. Basseres et al.   LUNG CANCER

Differential network biology

(2012) Trey Ideker et al.   Molecular Systems Biology

RedeR: R/Bioconductor package for representing modular structures, nested networks and multiple levels of hierarchical associations.

(2012) Mauro AA Castro et al.   GENOME BIOLOGY

FoxM1: A Master Regulator of Tumor Metastasis

(2011) P. Raychaudhuri et al.   CANCER RESEARCH

The Smad family and its role in pancreatic cancer

(2011) P Singh et al.   INDIAN JOURNAL OF CANCER

Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer

(2011) G S Coombs et al.   ONCOGENE

UHRF1 is a novel diagnostic marker of lung cancer

(2010) M Unoki et al.   BRITISH JOURNAL OF CANCER

FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers

(2010) Yunneng Tang et al.   CELL RESEARCH

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Attenuation of Forkhead signaling by the retinal determination factor DACH1

(2010) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF-2  deletion promotes Kras-driven lung tumor development

(2010) J. Mazumdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug discovery targeting epigenetic codes: The great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis

(2009) Motoko Unoki et al.   BIOCHEMICAL PHARMACOLOGY

UHRF1 inhibits MDR1 gene transcription and sensitizes breast cancer cells to anticancer drugs

(2009) Wei Jin et al.   BREAST CANCER RESEARCH AND TREATMENT

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

SMAD6 Contributes to Patient Survival in Non-Small Cell Lung Cancer and Its Knockdown Reestablishes TGF-  Homeostasis in Lung Cancer Cells

(2008) H.-S. Jeon et al.   CANCER RESEARCH

Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer

(2008) Giorgio Vittorio Scagliotti et al.   JOURNAL OF CLINICAL ONCOLOGY

Lung Cancer

(2008) Roy S. Herbst et al.   NEW ENGLAND JOURNAL OF MEDICINE