Methotrexate: a detailed review on drug delivery and clinical aspects

Therapeutic efficacy of experimental rheumatoid arthritis with low-dose methotrexate by increasing partially CD4+CD25+Treg cells and inducing Th1 to Th2 shift in both cells and cytokines

(2010) Song Xinqiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Development of methotrexate proline prodrug to overcome resistance by MDA-MB-231 cells

(2010) Zhiqian Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enhanced topical delivery and anti-inflammatory activity of methotrexate from an activated nanogel

(2010) Gillian S. Leslie Singka et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Synthesis and evaluation of a technetium-99m labeled cytotoxic bombesin peptide conjugate for targeting bombesin receptor-expressing tumors

(2010) Subhani M. Okarvi et al.   NUCLEAR MEDICINE AND BIOLOGY

Intrathecal methotrexate induces focal cognitive deficits and increases cerebrospinal fluid homocysteine

(2010) Yan Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Novel hyaluronic acid–methotrexate conjugates for osteoarthritis treatment

(2009) Akie Homma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Development of enzymatically cleavable prodrugs derived from dendritic polyglycerol

(2009) Marcelo Calderón et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Engineered chylomicron mimicking carrier emulsome for lymph targeted oral delivery of methotrexate

(2009) Rishi Paliwal et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats

(2009) Leos Fuksa et al.   TOXICOLOGY

Bax-associated mechanisms underlying the response of embryonic cells to methotrexate

(2009) S. Savion et al.   TOXICOLOGY IN VITRO

Novel insulin-like growth factor-methotrexate covalent conjugate inhibits tumor growth in vivo at lower dosage than methotrexate alone

(2009) Hugh McTavish et al.   Translational Research

Active targeting schemes for nanoparticle systems in cancer therapeutics

(2008) James D. Byrne et al.   ADVANCED DRUG DELIVERY REVIEWS

Liposomes containing alkylated methotrexate analogues for phospholipase A2 mediated tumor targeted drug delivery

(2008) Thomas Kaasgaard et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Infliximab and methotrexate in the treatment of rheumatoid arthritis: A systematic review and meta-analysis of dosage regimens

(2008) Elias Zintzaras et al.   CLINICAL THERAPEUTICS

Targeted delivery of methotrexate to skeletal muscular tissue by thermosensitive magnetoliposomes

(2008) Lin Zhu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Alefacept with methotrexate for treatment of psoriatic arthritis: Open-label extension of a randomized, double-blind, placebo-controlled study

(2008) Philip J. Mease et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Self-aggregated nanoparticles from methoxy poly(ethylene glycol)-modified chitosan: Synthesis; characterization; aggregation and methotrexate release in vitro

(2007) Xindu Yang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES