Article
Pharmacology & Pharmacy
Maki Fujimoto, Hitoshi Higuchi, Yuka Honda-Wakasugi, Saki Miyake, Yukiko Nishioka, Akiko Yabuki-Kawase, Shigeru Maeda, Takuya Miyawaki
Summary: The study investigated the anti-inflammatory mechanism of dexmedetomidine in inhibiting LPS-induced inflammatory responses. It was found that dexmedetomidine inhibits inflammation by activating PPAR gamma or increasing the production of 15d-PGJ2. The results suggest that dexmedetomidine inhibits LPS-induced inflammatory responses by binding to alpha(2) adrenoceptors and activating PPAR gamma.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Chunhui Nie, Bei Wang, Baoquan Wang, Ning Lv, Rui Yu, Enfan Zhang
Summary: The study revealed that protopine inhibits liver carcinoma cell viability by triggering apoptosis and suppressing the PI3K/Akt signaling pathway. In vivo experiments showed that protopine effectively repressed tumor growth without noticeable toxicity, indicating its potential as a therapeutic agent for liver carcinoma.
CANCER CELL INTERNATIONAL
(2021)
Review
Cell Biology
Kuangqi Chen, Yanqing Li, Xuhong Zhang, Rahim Ullah, Jianping Tong, Ye Shen
Summary: The PI3K/AKT signaling pathway plays a crucial role in the proliferation, migration, and anti-apoptosis of corneal epithelial cells (CECs). It can be activated by growth factors and NK-1, and regulated by reactive oxygen species (ROS) in a concentration-dependent manner. In diseases such as diabetic keratopathy (DK) and dry eye disease (DED), the PI3K/AKT signaling pathway is inhibited, but it is overactivated in keratitis.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Lei Wang, Mengmeng Yang, Huihan Jin
Summary: The study demonstrated that PI3K/AKT phosphorylation enhances ERR alpha activity in NOZ cells by upregulating the expression levels of PGC-1 alpha and PGC-1 beta, promoting the invasion and proliferation of gallbladder cancer cells.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Ching- Chang, Chuen-Mao Yang
Summary: 15d-PGJ(2) induces the expression of HO-1 in bEnd.3 cells through the activation of NOX- and mitochondria-derived ROS-dependent PKC delta/JNK1/2/Sp1/AP-1 signaling pathway, thus protecting against inflammatory responses.
Article
Biochemistry & Molecular Biology
Mydhili Govindarasu, Pari Abirami, Govindasamy Rajakumar, Mohammad Azam Ansari, Mohammad N. Alomary, Faris F. Aba Alkhayl, Abdulaziz A. Aloliqi, Muthu Thiruvengadam, Manju Vaiyapuri
Summary: Kaempferitrin shows promise as a potential therapeutic agent for colorectal cancer, as it inhibits cancer cell proliferation and induces apoptosis through the PI3K/AKT signaling pathway.
PROCESS BIOCHEMISTRY
(2022)
Article
Neurosciences
Huqing Wang, Ming Chen, Tao Zhang, Zhen Gao, Yu Gong, Xiaorui Yu, Haiqin Wu
Summary: In this study, it was observed that rhEPO intervention improved learning and memory abilities, enhanced antioxidant capacity, and reduced neuronal apoptosis in rats subjected to oxidative stress. The PI3K/Akt and PPAR gamma pathways were found to be involved in the protective effect of rhEPO on neurons. Furthermore, the study showed that rhEPO activates the PI3K/Akt pathway to upregulate PPAR gamma, thereby enhancing cellular antioxidant capacity and protecting neurons.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Meiyang Fan, Xiaofan Xiong, Lin Han, Lingyu Zhang, Shanfeng Gao, Liying Liu, Xiaofei Wang, Chen Huang, Dongdong Tong, Juan Yang, Lingyu Zhao, Yuan Shao
Summary: This study investigated the role and potential tumorigenic mechanisms of SERPINA5 in gastric cancer (GC). The findings showed that SERPINA5 was highly expressed in GC and promoted tumor development by modulating cell proliferation ability. Furthermore, SERPINA5 was found to inhibit CBL and regulate the PI3K/AKT/mTOR signaling pathway, thereby promoting GC progression. These results highlight the importance of SERPINA5 in GC and suggest its potential as a novel target for GC treatment and a predictor for prognosis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Huqing Wang, Ming Chen, Tao Zhang, Zhen Gao, Yu Gong, Xiaorui Yu, Haiqin Wu
Summary: This study confirmed that rhEPO can enhance the antioxidant capacity of cells and delay the senescence of nerve cells through the PI3K/Akt pathway by upregulating the expression of PGC-1 alpha and PPAR gamma.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Review
Medicine, Research & Experimental
Chun-Lin Xiao, Wen-Chao Yin, Yan-Chun Zhong, Jia-Quan Luo, Lu-Lin Liu, Wu-Yang Liu, Kai Zhao
Summary: Spinal cord injury is a severe central nervous system injury that leads to sensory and motor dysfunction. The PI3K/Akt signaling pathway plays a key role in the pathological processes and neuronal recovery of spinal cord injury, and its activation can promote neurological function recovery by reducing cell apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Wenwen Dong, Bei Luo, Chang Qiu, Xu Jiang, Bo Shen, Li Zhang, Weiguo Liu, Wenbin Zhang
Summary: The study demonstrates that TRIM3 may attenuate cell apoptosis in Parkinson's disease by activating the PI3K/AKT signaling pathway, thereby improving cell viability in PD.
Article
Oncology
Liliana Ordonez, Giusy Tornillo, Howard Kendrick, Trevor Hay, Matthew John Smalley
Summary: The interaction between NOTCH and PI3K/AKT signaling pathways determines the development and type of mammary tumors in mice.
Article
Cell Biology
Zuping Wu, Chenchen Zhou, Quan Yuan, Demao Zhang, Jing Xie, Shujuan Zou
Summary: CTGF promotes intercellular communication in chondrocytes through upregulating Cx43 expression and activating the PI3K/Akt signaling pathway.
CELL PROLIFERATION
(2021)
Article
Multidisciplinary Sciences
Feng Zhi, Bowen Li, Chuanxia Zhang, Fan Xia, Rong Wang, Weihong Xie, Sihui Cai, Dawei Zhang, Ren Kong, Yiqiao Hu, Yilin Yang, Ya Peng, Jun Cui
Summary: NLRP6 enhances the PI3K/AKT pathway by binding and degrading p85 alpha, promoting tumorigenesis. The interaction between NLRP6 and p85 alpha offers a potential therapeutic target for tumor treatment.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Vivek Makwana, Santosh Rudrawar, Shailendra Anoopkumar-Dukie
Summary: Hexosamine biosynthetic (HBP) and PI3K/AKT/mTOR pathways play crucial roles in the proliferation and survival of prostate cancer cells by increasing androgen receptor expression and protein levels. Inhibition of a single pathway is insufficient to halt disease progression, suggesting that targeting multiple pathways at common junctions may be beneficial for effective management of prostate cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Carine Lindquist, Bodil Bjorndal, Christine Renate Rossmann, Deusdedit Tusubira, Asbjorn Svardal, Gro Vatne Rosland, Karl Johan Tronstad, Seth Hallstroem, Rolf Kristian Berge
JOURNAL OF LIPID RESEARCH
(2017)
Article
Physiology
Gerhard Cvirn, Markus Kneihsl, Christine Rossmann, Margret Paar, Thomas Gattringer, Axel Schlagenhauf, Bettina Leschnik, Martin Koestenberger, Erwin Tafeit, Gilbert Reibnegger, Irhad Trozic, Andreas Roessler, Franz Fazekas, Nandu Goswami
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Multidisciplinary Sciences
Christine Rossmann, Christoph Nusshold, Margret Paar, Gerhard Ledinski, Erwin Tafeit, Martin Koestenberger, Eva Maria Bernhart, Wolfgang Sattler, Gerhard Cvirn, Seth Hallstroem
Article
Multidisciplinary Sciences
Carine Lindquist, Bodil Bjorndall, Christine Renate Rossmann, Asbjorn Svardal, Seth Hallstroem, Rolf Kristian Berge
Article
Multidisciplinary Sciences
Margret Paar, Christine Rossmann, Christoph Nusshold, Thomas Wagner, Axel Schlagenhauf, Bettina Leschnik, Karl Oettl, Martin Koestenberger, Gerhard Cvirn, Seth Hallstrom
Article
Physiology
Chintan N. Koyani, Christopher Trummer, Niroj Shrestha, Susanne Scheruebel, Benjamin Bourgeois, Ioanna Plastira, Sandra Kickmaier, Harald Sourij, Peter P. Rainer, Tobias Madl, Wolfgang Sattler, Brigitte Pelzmann, Ernst Malle, Dirk von Lewinski
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Immunology
Ioanna Plastira, Eva Bernhart, Lisha Joshi, Chintan N. Koyani, Heimo Strohmaier, Helga Reicher, Ernst Malle, Wolfgang Sattler
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Pharmacology & Pharmacy
Chintan N. Koyani, Ioanna Plastira, Harald Sourij, Seth Hallstrom, Albrecht Schmidt, Peter P. Rainer, Heiko Bugger, Sasa Frank, Ernst Malle, Dirk von Lewinski
PHARMACOLOGICAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Gesa Richter, Tianshu Gui, Benjamin Bourgeois, Chintan N. Koyani, Peter Ulz, Ellen Heitzer, Dirk von Lewinski, Boudewijn M. T. Burgering, Ernst Malle, Tobias Madl
Summary: The research identified the Wnt signaling pathway as a key target of FOXP2-dependent transcriptional regulation, showing that beta-catenin plays a role in regulating FOXP2 transcriptional activity. The study used nuclear magnetic resonance spectroscopy to uncover the molecular details of the interactions between beta-catenin and FOXP2, demonstrating the importance of the FOXP2 alpha-helical motif in transcriptional regulation.
Article
Biochemistry & Molecular Biology
Juergen Prasch, Eva Bernhart, Helga Reicher, Manfred Kollroser, Gerald N. Rechberger, Chintan N. Koyani, Christopher Trummer, Lavinia Rech, Peter P. Rainer, Astrid Hammer, Ernst Malle, Wolfgang Sattler
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Lisha Joshi, Ioanna Plastira, Eva Bernhart, Helga Reicher, Chintan N. Koyani, Tobias Madl, Corina Madreiter-Sokolowski, Zhanat Koshenov, Wolfgang F. Graier, Seth Hallstrom, Wolfgang Sattler
Summary: The study found that treatment with LPA can induce specific changes in the immunometabolic phenotype of BV-2 microglia, including a switch to aerobic glycolysis, de novo lipogenesis, increased amino acid content, generation of reactive oxygen species, and increased glutathione synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mahmoud Abdellatif, Viktoria Trummer-Herbst, Franziska Koser, Sylvere Durand, Rui Adao, Francisco Vasques-Novoa, Johanna K. Freundt, Julia Voglhuber, Maria-Rosaria Pricolo, Michael Kasa, Clara Turk, Fanny Aprahamian, Elias Herrero-Galan, Sebastian J. Hofer, Tobias Pendl, Lavinia Rech, Julia Kargl, Nathaly Anto-Michel, Senka Ljubojevic-Holzer, Julia Schipke, Christina Brandenberger, Martina Auer, Renate Schreiber, Chintan N. Koyani, Akos Heinemann, Andreas Zirlik, Albrecht Schmidt, Dirk von Lewinski, Daniel Scherr, Peter P. Rainer, Julia von Maltzahn, Christian Muhlfeld, Marcus Kruger, Sasa Frank, Frank Madeo, Tobias Eisenberg, Andreas Prokesch, Adelino F. Leite-Moreira, Andre P. Lourenco, Jorge Alegre-Cebollada, Stefan Kiechl, Wolfgang A. Linke, Guido Kroemer, Simon Sedej
Summary: The study suggests that using nicotinamide to increase NAD(+) can improve cardiac dysfunction in HFpEF patients by enhancing myocardial energy metabolism and directly improving cardiomyocyte function. High intake of naturally occurring NAD(+) precursors is associated with lower blood pressure and reduced risk of cardiac mortality.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Chintan N. Koyani, Susanne Scheruebel, Ge Jin, Ewald Kolesnik, Klaus Zorn-Pauly, Heinrich Maechler, Gerald Hoefler, Dirk von Lewinski, Frank R. Heinzel, Brigitte Pelzmann, Ernst Malle
Summary: Neutrophil-derived myeloperoxidase (MPO) and hypochlorous acid (HOCl) play important roles in cardiac damage and dysfunction. The presence of proatherogenic HOCl-LDL in infarcted human myocardium adversely affects electrophysiology and contractility of cardiomyocytes, leading to altered action potential characteristics and arrhythmic events. HOCl-LDL also affects the expression and function of key proteins in calcium handling, resulting in impaired contractility and calcium homeostasis.
Article
Pharmacology & Pharmacy
Chintan N. Koyani, Ewald Kolesnik, Gerald Woelkart, Niroj Shrestha, Susanne Scheruebel, Christopher Trummer, Klaus Zorn-Pauly, Astrid Hammer, Petra Lang, Helga Reicher, Heinrich Maechler, Klaus Groschner, Bernd Mayer, Peter P. Rainer, Harald Sourij, Wolfgang Sattler, Ernst Malle, Brigitte Pelzmann, Dirk von Lewinski
BIOCHEMICAL PHARMACOLOGY
(2017)
Article
Pharmacology & Pharmacy
G. Woelkart, A. Schrammel, C. N. Koyani, S. Scheruebel, K. Zorn-Pauly, E. Malle, B. Pelzmann, M. Andrae, A. Ortner, B. Mayer
BRITISH JOURNAL OF PHARMACOLOGY
(2017)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)