Article
Pharmacology & Pharmacy
Renkan Zhang, Ling Xie, Fangfang Wu, Ji Xu, Leilei Lu, Lin Cao, Lei Li, Weiyang Meng, Hongyu Zhang, Chuxiao Shao, Xiaokun Li, Daqing Chen
Summary: Promoting blood-spinal cord barrier (BSCB) repair at the early stage plays a crucial role in treatment of spinal cord injury (SCI). A sustained-release system of basic fibroblast growth factor (bFGF) (called ALG-bFGF) has been developed using sodium alginate hydrogel, which shows improved therapeutic effect in promoting SCI repair and motor function recovery. The mechanism involves the inhibition of autophagy activation and maintenance of BSCB integrity through the PI3K/Akt/FOXO1/KLF4 pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Shun Xu, Jin Wang, Junjie Zhong, Minghao Shao, Jianyuan Jiang, Jian Song, Wei Zhu, Fan Zhang, Haocheng Xu, Guangyu Xu, Yuxuan Zhang, Xiaosheng Ma, Feizhou Lyu
Summary: The study demonstrates that CD73 inhibits microglial pyroptosis by suppressing the activation of NLRP3 inflammasome complexes and reducing GSDMD maturation. CD73 regulates GSDMD expression at the transcriptional level through Foxo1, and forms a positive feedback loop with HIF-1 alpha.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Cell Biology
Yuanzhe Ding, Di Zhang, Sheng Wang, Xiaolei Zhang, Jingquan Yang
Summary: Spinal cord injury is a devastating disease causing loss of sensory and motor functions, with a pathological process involving mechanical primary injury and secondary injury. Macrophages play a crucial role in the pathology of SCI, and can be divided into different types. Hematogenous macrophages may have various roles in SCI but their specific function remains controversial.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Zhenxin Hu, Lina Xuan, Tingting Wu, Nizhou Jiang, Xiangjun Liu, Jiazhen Chang, Te Wang, Nan Han, Xiliang Tian
Summary: Taxifolin reduces neuroinflammation and microglial pyroptosis after spinal cord injury by inhibiting oxidative stress and regulating the PI3K/AKT signaling pathway. It also promotes axonal regeneration and improves functional recovery. Taxifolin may be a potential therapeutic agent for spinal cord injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Yi Ding, Qin Chen
Summary: Spinal cord injury (SCI) is a common disabling spinal injury, and the mTOR signaling pathway plays a crucial role in the pathological process. Chinese herbal medicine has been shown to promote nerve repair after SCI by inhibiting the mTOR pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Neurosciences
Xin-Yue Bai, Xiao-Long Liu, Zhi-Zhong Deng, Dong-Min Wei, Die Zhang, Hui-Lin Xi, Qing-Yan Wang, Meng-Ze He, Yan-Ling Yang
Summary: Spinal cord injury is a serious traumatic disease, and recent studies have shown that Ferroptosis is closely related to its pathophysiological processes. Iron overload, reactive oxygen species accumulation, lipid peroxidation, and glutamate accumulation associated with Ferroptosis are all present in spinal cord injury, indicating the involvement of Ferroptosis in the secondary pathological processes. This article highlights the relationship between Ferroptosis and spinal cord injury, presents substances that improve spinal cord injury by inhibiting Ferroptosis, and discusses the potential challenges in the clinical translation of Ferroptosis inhibitors.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cell Biology
Rui Zhao, Xue Wu, Xue-Yuan Bi, Hao Yang, Qian Zhang
Summary: Baicalin is a natural active ingredient that can cross the blood-brain barrier and has neuroprotective effects on multiple central nervous system diseases. This study investigated the mechanism of action of Baicalin in treating spinal cord injury and found that it can inhibit blood-spinal cord barrier permeability and reduce neuronal apoptosis by activating the PI3K/Akt signaling pathway.
NEURAL REGENERATION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Zhenfei Ding, Ce Dai, Lin Zhong, Rui Liu, Weilu Gao, Hui Zhang, Zongsheng Yin
Summary: The study demonstrated that Nrg1 could effectively convert reactive astrocytes to oligodendrocytes, inhibit astrogliosis, promote remyelination, protect axons, and improve SCI symptoms, suggesting a promising therapeutic strategy for spinal cord repair.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Anna Smaling, Lorenzo Romero-Ramirez, Jorg Mey
Summary: Bile acids have both metabolic and signaling functions, acting through a bile acid receptor TGR5. TUDCA, a bile acid, has been tested in animal models of spinal cord injury and showed cytoprotective effects. However, the evidence does not support its use as a treatment for SCI.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Orthopedics
Chengjun Li, Tian Qin, Yuxin Jin, Jianzhong Hu, Feifei Yuan, Yong Cao, Chunyue Duan
Summary: This study found that cerebrospinal fluid-derived extracellular vesicles (CSF-EVs) can promote vascular regeneration and improve motor function recovery after spinal cord injury (SCI) by activating the PI3K/AKT pathway. This provides a potential novel therapeutic approach for the treatment of acute SCI.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Biochemistry & Molecular Biology
Xiaohui Wang, Chao Jiang, Yongyuan Zhang, Zhe Chen, Hong Fan, Yuyang Zhang, Zhiyuan Wang, Fang Tian, Jing Li, Hao Yang, Dingjun Hao
Summary: The present study aimed to investigate the pro-angiogenic potential of OECs activated by CCM and LPS and the underlying mechanisms. The activated OECs were found to effectively promote proliferation, migration, and vessel-like structure formation of vascular endothelial cells. Several pro-angiogenic growth factors were significantly elevated in the conditioned medium (CM), and the PI3K/Akt signaling pathway was involved in these pro-angiogenic events. Transplantation of activated OECs improved angiogenesis and the microenvironment in the injured spinal cord.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jiachun Dong, Zijian Wei, Zezhang Zhu
Summary: In this study, the upregulated expression of lncRNA TSIX in spinal cord tissues following spinal cord injury (SCI) was investigated. The effects of lncRNA TSIX on spinal cord neural stem cell (SC-NSC) proliferation, migration, apoptosis, and inflammation were evaluated. Moreover, the miR-532-3p/DDOST axis was identified as the downstream pathway of lncRNA TSIX, and its effects on SC-NSCs were studied. Additionally, the PI3K/AKT signaling pathway was found to be activated by lncRNA TSIX. These findings suggest the potential therapeutic applications of targeting lncRNA TSIX in SCI regeneration.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Cell Biology
Chao-Hua Yang, Zheng-Xue Quan, Gao-Ju Wang, Tao He, Zhi-Yu Chen, Qiao-Chu Li, Jin Yang, Qing Wang
Summary: The current recommended management for acute traumatic spinal cord injury aims to reduce secondary injury incidence and promote functional recovery. Elevated ISP, mainly caused by hemorrhage, edema, and blood-spinal cord barrier destruction, peaks at 3 days after traumatic spinal cord injury. Promising treatments for reducing ISP within this time window include duraplasty and hypertonic saline.
NEURAL REGENERATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Rui Lima, Andreia Monteiro, Antonio J. Salgado, Susana Monteiro, Nuno A. Silva
Summary: Spinal cord injury (SCI) is a debilitating condition that lacks effective treatment options. Recent research has uncovered the complex mechanisms involved in SCI, leading to the development of new therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Scott R. Whittemore, Sujata Saraswat Ohri, Michael D. Forston, George Z. Wei, Michal Hetman
Summary: Proteostasis, regulated by multiple pathways, is crucial for cellular and organismal survival. Disruption of proteostasis may lead to cell apoptosis, while maintaining it contributes to the treatment of traumatic spinal cord injury.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)