BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis

Multidimensional quantitative analysis of mRNA expression within intact vertebrate embryos

(2018) Vikas Trivedi et al.   DEVELOPMENT

BMP-2/7 heterodimer strongly induces bone regeneration in the absence of increased soft tissue inflammation

(2018) Takashi Kaito et al.   Spine Journal

Prodomain–growth factor swapping in the structure of pro-TGF-β1

(2017) Bo Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping a multiplexed zoo of mRNA expression

(2016) Harry M. T. Choi et al.   DEVELOPMENT

Structure and activation of pro-activin A

(2016) Xuelu Wang et al.   Nature Communications

The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo

(2015) Judith M. Neugebauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice

(2014) A. Tilak et al.   DEVELOPMENT

Cleavage of the Drosophila screw prodomain is critical for a dynamic BMP morphogen gradient in embryogenesis

(2014) Jaana Künnapuu et al.   DEVELOPMENTAL BIOLOGY

Bmp signaling represses Vegfa to promote outflow tract cushion development

(2013) Y. Bai et al.   DEVELOPMENT

The signaling and functions of heterodimeric bone morphogenetic proteins

(2012) Jing Guo et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway

(2012) Minako Aoyama et al.   DEVELOPMENTAL CELL

A Large Bioactive BMP Ligand with Distinct Signaling Properties Is Produced by Alternative Proconvertase Processing

(2012) T. Akiyama et al.   Science Signaling

BMP4 loss-of-function mutations in developmental eye disorders including SHORT syndrome

(2011) Linda M. Reis et al.   HUMAN GENETICS

Different Requirements for Proteolytic Processing of Bone Morphogenetic Protein 5/6/7/8 Ligands inDrosophila melanogaster

(2011) Cornelia Fritsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Osteoconductive, Osteoinductive, and Osteogenic Tissue-Engineered Product for Trauma and Orthopaedic Surgery: How Far Are We?

(2011) Wasim S. Khan et al.   Stem Cells International

Bone Morphogenetic Proteins: A critical review

(2010) Beth Bragdon et al.   CELLULAR SIGNALLING

Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies

(2010) Alexander W. Wyatt et al.   HUMAN MUTATION

BMP-2/6 Heterodimer Is More Effective than BMP-2 or BMP-6 Homodimers as Inductor of Differentiation of Human Embryonic Stem Cells

(2010) Elvira Valera et al.   PLoS One

Mutations in BMP4 Are Associated with Subepithelial, Microform, and Overt Cleft Lip

(2009) Satoshi Suzuki et al.   AMERICAN JOURNAL OF HUMAN GENETICS

BMP and BMP receptor expression during murine organogenesis

(2009) Shahab M. Danesh et al.   GENE EXPRESSION PATTERNS

Bmp2andBmp4genetically interact to support multiple aspects of mouse development including functional heart development

(2009) Takashi Uchimura et al.   GENESIS

Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis

(2009) Shawn C. Little et al.   NATURE CELL BIOLOGY

Mutations in BMP4 Cause Eye, Brain, and Digit Developmental Anomalies: Overlap between the BMP4 and Hedgehog Signaling Pathways

(2008) Preeti Bakrania et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation

(2008) Andrew M Ho et al.   BMC DEVELOPMENTAL BIOLOGY

BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

(2008) David J. McCulley et al.   DEVELOPMENTAL DYNAMICS

A New Model for Growth Factor Activation: Type II Receptors Compete with the Prodomain for BMP-7

(2008) Gerhard Sengle et al.   JOURNAL OF MOLECULAR BIOLOGY

Genetic interaction between Bmp2 and Bmp4 reveals shared functions during multiple aspects of mouse organogenesis

(2008) Devorah C. Goldman et al.   MECHANISMS OF DEVELOPMENT