A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding

Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression

(2019) Ryan Mayle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An explanation for origin unwinding in eukaryotes

(2019) Lance D Langston et al.   eLife

A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core

(2018) Lukas Zimmermann et al.   JOURNAL OF MOLECULAR BIOLOGY

The mechanism of eukaryotic CMG helicase activation

(2018) Max E. Douglas et al.   NATURE

Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase

(2017) Marko Lõoke et al.   GENES & DEVELOPMENT

Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing

(2017) Simina Ticau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model

(2017) Yasunori Noguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading

(2017) Gideon Coster et al.   SCIENCE

Cryo-EM structure of a licensed DNA replication origin

(2017) Ferdos Abid Ali et al.   Nature Communications

Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing

(2017) Simina Ticau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphopeptide binding by Sld3 links Dbf4‐dependent kinase to MCM replicative helicase activation

(2016) Tom D Deegan et al.   EMBO JOURNAL

Chromosome Duplication in Saccharomyces cerevisiae

(2016) S. P. Bell et al.   GENETICS

The MCM Helicase Motor of the Eukaryotic Replisome

(2016) Ferdos Abid Ali et al.   JOURNAL OF MOLECULAR BIOLOGY

Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

(2016) Ferdos Abid Ali et al.   Nature Communications

Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

(2015) Simina Ticau et al.   CELL

Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex

(2015) Max E. Douglas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the eukaryotic MCM complex at 3.8 Å

(2015) Ningning Li et al.   NATURE

Regulated eukaryotic DNA replication origin firing with purified proteins

(2015) Joseph T. P. Yeeles et al.   NATURE

Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2–7 Helicase to Reveal Essential Features of Structure and Function

(2015) Justin M. Miller et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Cell-Cycle-Regulated Interaction between Mcm10 and Double Hexameric Mcm2-7 Is Required for Helicase Splitting and Activation during S Phase

(2015) Yun Quan et al.   Cell Reports

Empirical Bayes Methods Enable Advanced Population-Level Analyses of Single-Molecule FRET Experiments

(2014) Jan-Willem van de Meent et al.   BIOPHYSICAL JOURNAL

Multiple Functions for Mcm2–7 ATPase Motifs during Replication Initiation

(2014) Sukhyun Kang et al.   MOLECULAR CELL

Origin Licensing Requires ATP Binding and Hydrolysis by the MCM Replicative Helicase

(2014) Gideon Coster et al.   MOLECULAR CELL

Prereplication-complex formation: a molecular double take?

(2014) Hasan Yardimci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATPase-dependent quality control of DNA replication origin licensing

(2013) Jordi Frigola et al.   NATURE

Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA

(2013) Jingchuan Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of Transcription Initiation at an Activator-Dependent Promoter Defined by Single-Molecule Observation

(2012) Larry J. Friedman et al.   CELL

Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases

(2011) Ryan C. Heller et al.   CELL

Mec1 Is One of Multiple Kinases that Prime the Mcm2-7 Helicase for Phosphorylation by Cdc7

(2010) John C.W. Randell et al.   MOLECULAR CELL

The Dbf4–Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

(2010) Yi-Jun Sheu et al.   NATURE

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA