Gastrointestinal Immunity and Alpha-Synuclein

Microbiota and gut neuropeptides: a dual action of antimicrobial activity and neuroimmune response

(2019) Julia Aresti Sanz et al.   PSYCHOPHARMACOLOGY

Microbiome-Gut-Brain Axis and Toll-Like Receptors in Parkinson’s Disease

(2018) Valentina Caputi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diverse Inflammatory Response After Cerebral Microbleeds Includes Coordinated Microglial Migration and Proliferation

(2018) Sung Ji Ahn et al.   STROKE

Role of TLR4 in the gut-brain axis in Parkinson’s disease: a translational study from men to mice

(2018) Paula Perez-Pardo et al.   GUT

The vermiform appendix impacts the risk of developing Parkinson’s disease

(2018) Bryan A. Killinger et al.   Science Translational Medicine

A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity

(2017) Ethan Stolzenberg et al.   Journal of Innate Immunity

Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects

(2017) Julianna J. Tomlinson et al.   JOURNAL OF NEURAL TRANSMISSION

α-Synuclein promotes dilation of the exocytotic fusion pore

(2017) Todd Logan et al.   NATURE NEUROSCIENCE

Vagotomy and Parkinson disease

(2017) Bojing Liu et al.   NEUROLOGY

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

(2017) Michele Perni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulating membrane binding of α-synuclein as a therapeutic strategy

(2017) André Pineda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A secreted antibacterial neuropeptide shapes the microbiome of Hydra

(2017) René Augustin et al.   Nature Communications

Alpha-Synuclein, a Novel Viral Restriction Factor Hiding in Plain Sight

(2016) Aaron R. Massey et al.   DNA AND CELL BIOLOGY

The bowel and beyond: the enteric nervous system in neurological disorders

(2016) Meenakshi Rao et al.   Nature Reviews Gastroenterology & Hepatology

Cytokines IL-17 and IL-22 in the host response to infection

(2016) Maria Valeri et al.   Pathogens and Disease

Does vagotomy reduce the risk of Parkinson's disease: The authors reply

(2015) Elisabeth Svensson et al.   ANNALS OF NEUROLOGY

Ligand Recognition Specificity of Leukocyte Integrin αMβ2 (Mac-1, CD11b/CD18) and Its Functional Consequences

(2015) Nataly P. Podolnikova et al.   BIOCHEMISTRY

Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells

(2015) Diego V. Bohórquez et al.   JOURNAL OF CLINICAL INVESTIGATION

Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain

(2015) Erica L. Beatman et al.   JOURNAL OF VIROLOGY

Gastrointestinal dysfunction in Parkinson's disease

(2015) Alfonso Fasano et al.   LANCET NEUROLOGY

α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation

(2015) Shijun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Surface area of the digestive tract – revisited

(2014) Herbert F Helander et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Paneth Cells: Maestros of the Small Intestinal Crypts

(2013) Hans C. Clevers et al.   Annual Review of Physiology

Alpha-synuclein in the appendiceal mucosa of neurologically intact subjects

(2013) Madison T. Gray et al.   MOVEMENT DISORDERS

Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease

(2013) Leo P. Kelly et al.   MOVEMENT DISORDERS

The gut as a sensory organ

(2013) John B. Furness et al.   Nature Reviews Gastroenterology & Hepatology

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-dependent secretion of alpha-synuclein by enteric neurons

(2012) Sébastien Paillusson et al.   JOURNAL OF NEUROCHEMISTRY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

(2011) Charles L. Bevins et al.   NATURE REVIEWS MICROBIOLOGY

The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding

(2010) Tim Bartels et al.   BIOPHYSICAL JOURNAL

Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles

(2010) Elizabeth R. Middleton et al.   BIOPHYSICAL JOURNAL

Herpes Simplex Virus Type 1 Infection of the Rat Enteric Nervous System Evokes Small-Bowel Neuromuscular Abnormalities

(2010) Paola Brun et al.   GASTROENTEROLOGY

   -Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

(2010) B. Greten-Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration

(2009) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Red Blood Cells Are the Major Source of Alpha-Synuclein in Blood

(2008) Robin Barbour et al.   Neurodegenerative Diseases

NOD2-expressing bone marrow-derived cells appear to regulate epithelial innate immunity of the transplanted human small intestine

(2007) T Fishbein et al.   GUT