The role of mRNA m6A methylation in the nervous system

Epitranscriptomics: Correlation of N6-methyladenosine RNA methylation and pathway dysregulation in the hippocampus of HIV transgenic rats

(2019) Yu Fu et al.   PLoS One

N6-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling

(2019) Abhirami Visvanathan et al.   Genes

The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression

(2019) Mengru Zhuang et al.   NUCLEIC ACIDS RESEARCH

m6A RNA methylation regulators contribute to malignant progression and have clinical prognostic impact in gliomas

(2019) Rui-Chao Chai et al.   Aging-US

Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death

(2019) Xuechai Chen et al.   ACS Chemical Neuroscience

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

(2019) Hailing Shi et al.   MOLECULAR CELL

N6-methyladenosine modifications: interactions with novel RNA-binding proteins and roles in signal transduction

(2019) Jiaxin Chen et al.   RNA Biology

Regulation of Gene Expression by N-methyladenosine in Cancer

(2019) Jun Liu et al.   TRENDS IN CELL BIOLOGY

The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons

(2019) Johan Ruud et al.   Cell Reports

FTO genotype impacts food intake and corticolimbic activation

(2018) Susan J Melhorn et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling

(2018) Huajie Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

(2018) Ying Yang et al.   CELL RESEARCH

RNA N6-methyladenosine modification in cancers: current status and perspectives

(2018) Xiaolan Deng et al.   CELL RESEARCH

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d

(2018) Philip Knuckles et al.   GENES & DEVELOPMENT

Role of RNA modifications in brain and behavior

(2018) Y. Jung et al.   GENES BRAIN AND BEHAVIOR

Epigenetics and epitranscriptomics in temporal patterning of cortical neural progenitor competence

(2018) Ki-Jun Yoon et al.   JOURNAL OF CELL BIOLOGY

The m6A-epitranscriptomic signature in neurobiology:from neurodevelopment to brain plasticity

(2018) Jocelyn Widagdo et al.   JOURNAL OF NEUROCHEMISTRY

Zc3h13 Regulates Nuclear RNA m 6 A Methylation and Mouse Embryonic Stem Cell Self-Renewal

(2018) Jing Wen et al.   MOLECULAR CELL

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts

(2018) Daria Merkurjev et al.   NATURE NEUROSCIENCE

Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning

(2018) Jessica L. Koranda et al.   NEURON

Epitranscriptomic m 6 A Regulation of Axon Regeneration in the Adult Mammalian Nervous System

(2018) Yi-Lan Weng et al.   NEURON

FTO affects food cravings and interacts with age to influence age-related decline in food cravings

(2018) Linh C. Dang et al.   PHYSIOLOGY & BEHAVIOR

m6A demethylase FTO regulates dopaminergic neurotransmission deficits caused by arsenite

(2018) LuLu Bai et al.   TOXICOLOGICAL SCIENCES

Reading m 6 A in the Transcriptome: m 6 A-Binding Proteins

(2018) Deepak P. Patil et al.   TRENDS IN CELL BIOLOGY

METTL3-mediated m6A modification is required for cerebellar development

(2018) Chen-Xin Wang et al.   PLOS BIOLOGY

Epigenetic Regulations in Neural Stem Cells and Neurological Diseases

(2018) Hang Zhou et al.   Stem Cells International

Epitranscriptomics: A New Regulatory Mechanism of Brain Development and Function

(2018) Florian Noack et al.   Frontiers in Neuroscience

Above the Epitranscriptome: RNA Modifications and Stem Cell Identity

(2018) Francesco Morena et al.   Genes

YTH Domain: A Family of N 6 -methyladenosine (m 6 A) Readers

(2018) Shanhui Liao et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

(2018) Yanan Yue et al.   Cell Discovery

Chemical Modifications in the Life of an mRNA Transcript

(2018) Sigrid Nachtergaele et al.   Annual Review of Genetics

The Obesity Related Gene, FTO, Interacts with APOE, and is Associated with Alzheimer's Disease Risk: A Prospective Cohort Study

(2018) Lina Keller et al.   JOURNAL OF ALZHEIMERS DISEASE

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

(2018) Alessandro Bertero et al.   NATURE

Epitranscriptomes in the Adult Mammalian Brain: Dynamic Changes Regulate Behavior

(2018) Ki-Jun Yoon et al.   NEURON

The Role of m6A/m-RNA Methylation in Stress Response Regulation

(2018) Mareen Engel et al.   NEURON

Structural insights into the RNA methyltransferase domain of METTL16

(2018) Agnieszka Ruszkowska et al.   Scientific Reports

A novel m6A reader Prrc2a controls oligodendroglial specification and myelination

(2018) Rong Wu et al.   CELL RESEARCH

m6A-epitranscriptome modulates memory strength

(2018) Sebastian Krüttner et al.   CELL RESEARCH

METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation

(2018) Zeyu Zhang et al.   CELL RESEARCH

m6A facilitates hippocampus-dependent learning and memory through YTHDF1

(2018) Hailing Shi et al.   NATURE

N6-Methyladenosine in RNA and DNA: An Epitranscriptomic and Epigenetic Player Implicated in Determination of Stem Cell Fate

(2018) Pengfei Ji et al.   Stem Cells International

Experience-dependent neural plasticity, learning, and memory in the era of epitranscriptomics

(2017) L. J. Leighton et al.   GENES BRAIN AND BEHAVIOR

The emerging role of mRNA methylation in normal and pathological behavior

(2017) M. Engel et al.   GENES BRAIN AND BEHAVIOR

Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis

(2017) Liping Li et al.   HUMAN MOLECULAR GENETICS

Corrigendum: Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

(2017) Xiang Wang et al.   NATURE

Epimetronomics: m6A Marks the Tempo of Corticogenesis

(2017) Nathan C. Boles et al.   NEURON

The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation

(2017) Brandon J Walters et al.   NEUROPSYCHOPHARMACOLOGY

Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI

(2017) Kamil Růžička et al.   NEW PHYTOLOGIST

Dynamic m6A modification regulates local translation of mRNA in axons

(2017) Jun Yu et al.   NUCLEIC ACIDS RESEARCH

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing

(2017) Marek Bartosovic et al.   NUCLEIC ACIDS RESEARCH

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

(2017) Nian Liu et al.   NUCLEIC ACIDS RESEARCH

Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance

(2017) A Visvanathan et al.   ONCOGENE

ALKBH10B Is an RNAN6-Methyladenosine Demethylase Affecting Arabidopsis Floral Transition

(2017) Hong-Chao Duan et al.   PLANT CELL

Fat mass and obesity-associated gene (FTO) is associated to eating disorders susceptibility and moderates the expression of psychopathological traits

(2017) Giovanni Castellini et al.   PLoS One

Our views of dynamic N 6 -methyladenosine RNA methylation

(2017) Boxuan Simen Zhao et al.   RNA

m 6 A in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression

(2017) Jean-Yves Roignant et al.   TRENDS IN GENETICS

S -Adenosylmethionine Synthesis Is Regulated by Selective N 6 -Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1

(2017) Hiroki Shima et al.   Cell Reports

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

Region-specific RNA m 6 A methylation represents a new layer of control in the gene regulatory network in the mouse brain

(2017) Mengqi Chang et al.   Open Biology

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

(2017) Ian A Roundtree et al.   eLife

RNA epigenetics — chemical messages for posttranscriptional gene regulation

(2016) Ian A Roundtree et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

An obesity-associated risk allele within theFTOgene affects human brain activity for areas important for emotion, impulse control and reward in response to food images

(2016) Lyle Wiemerslage et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Resting-State Brain and the FTO Obesity Risk Allele: Default Mode, Sensorimotor, and Salience Network Connectivity Underlying Different Somatosensory Integration and Reward Processing between Genotypes

(2016) Gaia Olivo et al.   Frontiers in Human Neuroscience

A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1

(2016) Rene Geissler et al.   GENES & DEVELOPMENT

Experience-Dependent Accumulation of N 6 -Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice

(2016) Jocelyn Widagdo et al.   JOURNAL OF NEUROSCIENCE

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

(2016) Wen Xiao et al.   MOLECULAR CELL

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

Evolving insights into RNA modifications and their functional diversity in the brain

(2016) Sarah Nainar et al.   NATURE NEUROSCIENCE

Epigenetic mechanisms in neurogenesis

(2016) Bing Yao et al.   NATURE REVIEWS NEUROSCIENCE

FTO gene variant modulates the neural correlates of visual food perception

(2016) Anne B. Kühn et al.   NEUROIMAGE

m6A: Signaling for mRNA splicing

(2016) Samir Adhikari et al.   RNA Biology

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

(2016) Hao Du et al.   Nature Communications

Recent advances in dynamic m6A RNA modification

(2016) Guangchao Cao et al.   Open Biology

Reviving the RNA World: An Insight into the Appearance of RNA Methyltransferases

(2016) Ajay K. Rana et al.   Frontiers in Genetics

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

N 6-methyladenosine modification in mRNA: machinery, function and implications for health and diseases

(2015) Arpita Maity et al.   FEBS Journal

A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation

(2015) Shengdong Ke et al.   GENES & DEVELOPMENT

RNAN6-methyladenosine methylation in post-transcriptional gene expression regulation

(2015) Yanan Yue et al.   GENES & DEVELOPMENT

An Obesity-Predisposing Variant of the FTO Gene Regulates D2R-Dependent Reward Learning

(2015) M. Sevgi et al.   JOURNAL OF NEUROSCIENCE

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

RNA epigenetics

(2015) Nian Liu et al.   Translational Research

Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine

(2014) Tingting Zhu et al.   CELL RESEARCH

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells

(2014) Pedro J. Batista et al.   Cell Stem Cell

Fat mass and obesity-associated (FTO) protein interacts with CaMKII and modulates the activity of CREB signaling pathway

(2014) L. Lin et al.   HUMAN MOLECULAR GENETICS

Crystal Structures of the Human RNA Demethylase Alkbh5 Reveal Basis for Substrate Recognition

(2014) Chong Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FTO genotype and aging: pleiotropic longitudinal effects on adiposity, brain function, impulsivity and diet

(2014) Y-F Chuang et al.   MOLECULAR PSYCHIATRY

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

(2014) Chao Xu et al.   Nature Chemical Biology

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

(2014) Kate D. Meyer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry

(2013) Martin E Hess et al.   NATURE NEUROSCIENCE

Association between obesity-related geneFTOand ADHD

(2013) Zia Choudhry et al.   Obesity

Sprouts of RNA epigenetics

(2013) Guanqun Zheng et al.   RNA Biology

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

FTO, obesity and the adolescent brain

(2012) Melkaye G. Melka et al.   HUMAN MOLECULAR GENETICS

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression

(2012) Z Samaan et al.   MOLECULAR PSYCHIATRY

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Genetic Variants in the Fat and Obesity Associated (FTO) Gene and Risk of Alzheimer's Disease

(2012) Christiane Reitz et al.   PLoS One

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

The growth hormone—IGF-I axis as a mediator for the association between FTO variants and body mass index: results of the Study of Health in Pomerania

(2010) D Rosskopf et al.   INTERNATIONAL JOURNAL OF OBESITY

A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly

(2010) A. J. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA