Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: a joint publication from the AABB and the International Society for Cell & Gene Therapy

Viral inactivation of human platelet lysate by gamma irradiation preserves its optimal efficiency in the expansion of human bone marrow mesenchymal stromal cells

(2019) Sabrina Viau et al.   TRANSFUSION

Human platelet lysate current standards and future developments

(2019) Reinhard Henschler et al.   TRANSFUSION

Manufacturing mesenchymal stromal cells for the treatment of graft-versus-host disease: a survey amongst centers affiliated to the European Group of Blood and Marrow Transplantation

(2018) Cristina Trento et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Comparison of human platelet lysate alternatives using expired and freshly isolated platelet concentrates for adipose-derived stromal cell expansion

(2018) Carla Dessels et al.   PLATELETS

Development of large-scale manufacturing of adipose-derived stromal cells for clinical applications using bioreactors and human platelet lysate

(2018) Mandana Haack-Sørensen et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Manufacture of endothelial colony-forming progenitor cells from steady-state peripheral blood leukapheresis using pooled human platelet lysate

(2018) Georg Siegel et al.   TRANSFUSION

Optimized human platelet lysate as novel basis for a serum-, xeno-, and additive-free corneal endothelial cell and tissue culture

(2017) Daniel Thieme et al.   Journal of Tissue Engineering and Regenerative Medicine

Clinical-scale expansion of adipose-derived stromal cells starting from stromal vascular fraction in a single-use bioreactor: proof of concept for autologous applications

(2017) Mélanie Gadelorge et al.   Journal of Tissue Engineering and Regenerative Medicine

Platelet lysate activates quiescent cell proliferation and reprogramming in human articular cartilage: Involvement of hypoxia inducible factor 1

(2017) Van Thi Nguyen et al.   Journal of Tissue Engineering and Regenerative Medicine

Pathogen reduction through additive-free short-wave UV light irradiation retains the optimal efficacy of human platelet lysate for the expansion of human bone marrow mesenchymal stem cells

(2017) Sabrina Viau et al.   PLoS One

Concise Review: MSC-Derived Exosomes for Cell-Free Therapy

(2017) Donald G. Phinney et al.   STEM CELLS

First Zika-positive donations in the continental United States

(2017) Susan A. Galel et al.   TRANSFUSION

Comparative analyses of industrial-scale human platelet lysate preparations

(2017) Jan Pierce et al.   TRANSFUSION

First cases of Zika virus-infected US blood donors outside states with areas of active transmission

(2017) Phillip C. Williamson et al.   TRANSFUSION

International Forum on GMP-grade human platelet lysate for cell propagation

(2017) D. Strunk et al.   VOX SANGUINIS

International Forum on GMP-grade human platelet lysate for cell propagation: summary

(2017) D. Strunk et al.   VOX SANGUINIS

Human platelet lysate: Replacing fetal bovine serum as a gold standard for human cell propagation?

(2016) Thierry Burnouf et al.   BIOMATERIALS

The design and synthesis of new synthetic low-molecular-weight heparins

(2016) K. Chandarajoti et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pathogen-reduced Ebola virus convalescent plasma: first steps towards standardization of manufacturing and quality control including assessment of Ebola-specific neutralizing antibodies

(2016) C. Geisen et al.   VOX SANGUINIS

Platelet lysate as a substitute for animal serum for the ex-vivo expansion of mesenchymal stem/stromal cells: present and future

(2016) Giuseppe Astori et al.   Stem Cell Research & Therapy

Feasibility and Efficiency of Human Bone Marrow Stromal Cell Culture with Allogeneic Platelet Lysate-Supplementation for Cell Therapy against Stroke

(2016) Chengbo Tan et al.   Stem Cells International

Spezifische Aspekte zur Virussicherheit von Produktionshilfsstoffen für somatische Zelltherapie-Arzneimittel

(2015) Albert Stühler et al.   Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz

Expired and Pathogen-Inactivated Platelet Concentrates Support Differentiation and Immunomodulation of Mesenchymal Stromal Cells in Culture

(2015) Sandra Mjoll Jonsdottir-Buch et al.   CELL TRANSPLANTATION

A robust and reproducible animal serum-free culture method for clinical-grade bone marrow-derived mesenchymal stromal cells

(2015) Anita Laitinen et al.   CYTOTECHNOLOGY

Culture of human cell lines by a pathogen-inactivated human platelet lysate

(2015) R. Fazzina et al.   CYTOTECHNOLOGY

Preparation, quality criteria, and properties of human blood platelet lysate supplements for ex vivo stem cell expansion

(2015) Daniel Tzu-Bi Shih et al.   New Biotechnology

Long-Term Expansion in Platelet Lysate Increases Growth of Peripheral Blood-Derived Endothelial-Colony Forming Cells and Their Growth Factor-Induced Sprouting Capacity

(2015) Dimitar Tasev et al.   PLoS One

Development of blood transfusion product pathogen reduction treatments: A review of methods, current applications and demands

(2015) Vishal Salunkhe et al.   TRANSFUSION AND APHERESIS SCIENCE

Determining the Effect of Preparation and Storage: An Effort to Streamline Platelet Components as a Source of Growth Factors for Clinical Application

(2015) Atul Sonker et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

Differential Expression Analysis by RNA-Seq Reveals Perturbations in the Platelet mRNA Transcriptome Triggered by Pathogen Reduction Systems

(2015) Abdimajid Osman et al.   PLoS One

Human platelet lysate is a feasible candidate to replace fetal calf serum as medium supplement for blood vascular and lymphatic endothelial cells

(2014) Pablo Hofbauer et al.   CYTOTHERAPY

Inactivated human platelet lysate with psoralen: a new perspective for mesenchymal stromal cell production in Good Manufacturing Practice conditions

(2014) Sara Castiglia et al.   CYTOTHERAPY

Pathogen-free, plasma-poor platelet lysate and expansion of human mesenchymal stem cells

(2014) Paola Iudicone et al.   Journal of Translational Medicine

Effects of pathogen reduction systems on platelet microRNAs, mRNAs, activation, and function

(2014) Abdimajid Osman et al.   PLATELETS

Emerging Pathogens - How Safe is Blood?

(2014) Michael Schmidt et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

Proteome Changes in Platelets After Pathogen Inactivation—An Interlaboratory Consensus

(2014) Michel Prudent et al.   TRANSFUSION MEDICINE REVIEWS

Alternatives to the use of fetal bovine serum: human platelet lysates as a serum substitute in cell culture media

(2014) Caroline Rauch   ALTEX-Alternatives to Animal Experimentation

Effects of Platelet Lysate Preparations on the Proliferation of HaCaT Cells

(2014) Sae Yun Baik et al.   Annals of Laboratory Medicine

Treatment of Graft versus Host Disease with Mesenchymal Stromal Cells: A Phase I Study on 40 Adult and Pediatric Patients

(2013) Martino Introna et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The effect of Platelet Lysate on osteoblast proliferation associated with a transient increase of the inflammatory response in bone regeneration

(2013) Alessandra Ruggiu et al.   BIOMATERIALS

The effect of platelet lysate fibrinogen on the functionality of MSCs in immunotherapy

(2013) Ian B. Copland et al.   BIOMATERIALS

Functional and differential proteomic analyses to identify platelet derived factors affecting ex vivo expansion of mesenchymal stromal cells

(2013) Sven Kinzebach et al.   BMC CELL BIOLOGY

Update on the use of pathogen-reduced human plasma and platelet concentrates

(2013) Axel Seltsam et al.   BRITISH JOURNAL OF HAEMATOLOGY

Serum-converted platelet lysate can substitute for fetal bovine serum in human mesenchymal stromal cell cultures

(2013) Mariluz P. Mojica-Henshaw et al.   CYTOTHERAPY

Heparin concentration is critical for cell culture with human platelet lysate

(2013) Hatim Hemeda et al.   CYTOTHERAPY

Clinical-Grade Mesenchymal Stromal Cells Produced Under Various Good Manufacturing Practice Processes Differ in Their Immunomodulatory Properties: Standardization of Immune Quality Controls

(2013) Cedric Menard et al.   STEM CELLS AND DEVELOPMENT

Dual Effect of Platelet Lysate on Human Articular Cartilage: A Maintenance of Chondrogenic Potential and a Transient Proinflammatory Activity Followed by an Inflammation Resolution

(2013) Rui Cruz Pereira et al.   TISSUE ENGINEERING PART A

Virally inactivated human platelet concentrate lysate induces regulatory T cells and immunosuppressive effect in a murine asthma model

(2013) Yueh-Lun Lee et al.   TRANSFUSION

Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices

(2013) Ratti Ram Sharma et al.   TRANSFUSION

Platelet Lysate as Replacement for Fetal Bovine Serum in Mesenchymal Stromal Cell Cultures

(2013) Karen Bieback   TRANSFUSION MEDICINE AND HEMOTHERAPY

GMP-Compliant Isolation and Expansion of Bone Marrow-Derived MSCs in the Closed, Automated Device Quantum Cell Expansion System

(2012) Markus T. Rojewski et al.   CELL TRANSPLANTATION

Heparin Disrupts the CXCR4/SDF-1 Axis and Impairs the Functional Capacity of Bone Marrow–Derived Mononuclear Cells Used for Cardiovascular Repair

(2012) Florian H. Seeger et al.   CIRCULATION RESEARCH

Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: production process, content and identification of active components

(2012) Natalie Fekete et al.   CYTOTHERAPY

Platelet lysate suppresses the expression of lipocalin-type prostaglandin D2 synthase that positively controls adipogenic differentiation of human mesenchymal stromal cells

(2012) Claudia Lange et al.   EXPERIMENTAL CELL RESEARCH

Donor Age of Human Platelet Lysate Affects Proliferation and Differentiation of Mesenchymal Stem Cells

(2012) Michael Lohmann et al.   PLoS One

Component pathogen inactivation: a critical review

(2012) C. V. Prowse   VOX SANGUINIS

Safety and Complications Reporting Update on the Re-Implantation of Culture-Expanded Mesenchymal Stem Cells Using Autologous Platelet Lysate Technique

(2012) Christopher J. Centeno et al.   Current Stem Cell Research & Therapy

Species-specific identification of ruminant components contaminating industrial crude porcine heparin using real-time fluorescent qualitative and quantitative PCR

(2011) Qing Huang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Mesenchymal stem cells expanded in human platelet lysate display a decreased inhibitory capacity on T- and NK-cell proliferation and function

(2011) Heba Abdelrazik et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Safety of Bovine Sera for Production of Mesenchymal Stem Cells for Therapeutic Use

(2011) Jens Reinhardt et al.   HUMAN GENE THERAPY

Immunomodulative Efficacy of Bone Marrow-Derived Mesenchymal Stem Cells Cultured in Human Platelet Lysate

(2011) Antoinette Flemming et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Mesenchymal stem cells and platelet lysate in fibrin or collagen scaffold promote non-cemented hip prosthesis integration

(2011) Barbara Dozza et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

UVC Irradiation for Pathogen Reduction of Platelet Concentrates and Plasma

(2011) Axel Seltsam et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

Impact of individual platelet lysates on isolation and growth of human mesenchymal stromal cells

(2010) Patrick Horn et al.   CYTOTHERAPY

Optimization of chemically defined cell culture media – Replacing fetal bovine serum in mammalian in vitro methods

(2010) J. van der Valk et al.   TOXICOLOGY IN VITRO

Expansion of adipose tissue mesenchymal stromal progenitors in serum-free medium supplemented with virally inactivated allogeneic human platelet lysate

(2010) Daniel Tzu-Bi Shih et al.   TRANSFUSION

Humanized large-scale expanded endothelial colony-forming cells function in vitro and in vivo

(2009) A. Reinisch et al.   BLOOD

Lessons learned from the contamination of heparin

(2009) Haiying Liu et al.   NATURAL PRODUCT REPORTS

Human Alternatives to Fetal Bovine Serum for the Expansion of Mesenchymal Stromal Cells from Bone Marrow

(2009) Karen Bieback et al.   STEM CELLS

Platelet Lysate as a Serum Substitute for 2D Static and 3D Perfusion Culture of Stromal Vascular Fraction Cells from Human Adipose Tissue

(2009) Andreas Marc Müller et al.   TISSUE ENGINEERING PART A

Comparison of ex vivo expansion culture conditions of mesenchymal stem cells for human cell therapy

(2009) Maitane Pérez-Ilzarbe et al.   TRANSFUSION

Transfusion of platelet components prepared with photochemical pathogen inactivation treatment during a Chikungunya virus epidemic in Ile de La Réunion

(2009) Patrice Rasonglès et al.   TRANSFUSION

TRANSPLANTATION AND CELLULAR ENGINEERING: Adipose tissue mesenchymal stem cell expansion in animal serum-free medium supplemented with autologous human platelet lysate

(2009) Ivan Souza Blande et al.   TRANSFUSION

Platelet utilization in the developing world: Strategies to optimize platelet transfusion practices

(2009) Anupam Verma et al.   TRANSFUSION AND APHERESIS SCIENCE

Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium

(2008) M von Bonin et al.   BONE MARROW TRANSPLANTATION

Rapid Large-Scale Expansion of Functional Mesenchymal Stem Cells from Unmanipulated Bone Marrow Without Animal Serum

(2008) Katharina Schallmoser et al.   TISSUE ENGINEERING PART C-METHODS

Solvent/detergent treatment of platelet concentrates enhances the release of growth factors

(2008) Thierry Burnouf et al.   TRANSFUSION

Experience of German Red Cross blood donor services with nucleic acid testing: results of screening more than 30 million blood donations for human immunodeficiency virus-1, hepatitis C virus, and hepatitis B virus

(2008) Michael K. Hourfar et al.   TRANSFUSION