Characterizing the inhibition of α‐synuclein oligomerization by a pharmacological chaperone that prevents prion formation by the protein PrP

Early stages of aggregation of engineered α-synuclein monomers and oligomers in solution

(2019) Xi Li et al.   Scientific Reports

13C APSY-NMR for sequential assignment of intrinsically disordered proteins

(2018) Maria Grazia Murrali et al.   JOURNAL OF BIOMOLECULAR NMR

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding

(2018) Farah El Turk et al.   PROTEIN SCIENCE

Structural characteristics and membrane interactions of tandem α-synuclein oligomers

(2018) Chunhua Dong et al.   Scientific Reports

Therapeutic approaches to target alpha-synuclein pathology

(2017) Patrik Brundin et al.   EXPERIMENTAL NEUROLOGY

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

(2017) Giuliana Fusco et al.   SCIENCE

Phthalocyanines as Molecular Scaffolds to Block Disease-Associated Protein Aggregation

(2016) Ariel A. Valiente-Gabioud et al.   ACCOUNTS OF CHEMICAL RESEARCH

First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers

(2016) Dale B. Schenk et al.   MOVEMENT DISORDERS

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

(2016) Marija Iljina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein

(2016) Amar Nath Gupta et al.   Nature Communications

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Piceatannol and Other Wine Stilbenes: A Pool of Inhibitors against α-Synuclein Aggregation and Cytotoxicity

(2016) Hamza Temsamani et al.   Nutrients

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein

(2016) Tania Massignan et al.   Scientific Reports

Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease

(2016) Lars Tatenhorst et al.   Acta Neuropathologica Communications

Photoexcited Porphyrins as a Strong Suppressor of β-Amyloid Aggregation and Synaptic Toxicity

(2015) Byung Il Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intracellular Screening of a Peptide Library to Derive a Potent Peptide Inhibitor of α-Synuclein Aggregation

(2015) Harish Cheruvara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

(2015) Benjamin Dehay et al.   LANCET NEUROLOGY

A carboxylated Zn-phthalocyanine inhibits fibril formation of Alzheimer's amyloid β peptide

(2014) Shatera Tabassum et al.   FEBS Journal

The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

(2014) Riccardo Porcari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Epigallocatechin Gallate Can Inhibit α-Synuclein Oligomer Toxicityin Vitro

(2014) Nikolai Lorenzen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Quantum Rod Diffusion by Polarized Fluorescence Correlation Spectroscopy

(2014) Jaeran Lee et al.   JOURNAL OF FLUORESCENCE

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

(2013) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

Inhibition of Tau Filament Formation by Conformational Modulation

(2013) Elias Akoury et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells

(2013) Christopher A. Waudby et al.   PLoS One

Mechanistic Insight into the Relationship between N-Terminal Acetylation of α-Synuclein and Fibril Formation Rates by NMR and Fluorescence

(2013) Lijuan Kang et al.   PLoS One

Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Phthalocyanine tetrasulfonates bind to multiple sites on natively-folded prion protein

(2012) Derek R. Dee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms

(2012) Tingyu Liu et al.   ChemMedChem

Direct observation of multiple misfolding pathways in a single prion protein molecule

(2012) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward the Discovery of Effective Polycyclic Inhibitors of α-Synuclein Amyloid Assembly

(2011) Gonzalo R. Lamberto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic Interactions between A , Tau, and  -Synuclein: Acceleration of Neuropathology and Cognitive Decline

(2010) L. K. Clinton et al.   JOURNAL OF NEUROSCIENCE

Pharmacological chaperone for the structured domain of human prion protein

(2010) Andrew J. Nicoll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Darwinian Evolution of Prions in Cell Culture

(2010) J. Li et al.   SCIENCE

Unfolded-State Structure and Dynamics Influence the Fibril Formation of Human Prion Protein

(2009) Christian Gerum et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficacy of phthalocyanine tetrasulfonate against mouse-adapted human prion strains

(2009) Hanin Abdel-Haq et al.   ARCHIVES OF VIROLOGY

Molecular Mechanisms Underlying the Flavonoid-Induced Inhibition of α-Synuclein Fibrillation

(2009) Xiaoyun Meng et al.   BIOCHEMISTRY

Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial

(2009) John Collinge et al.   LANCET NEUROLOGY

Structural and mechanistic basis behind the inhibitory interaction of PcTS on α-synuclein amyloid fibril formation

(2009) Gonzalo R. Lamberto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of an N-Methylated Peptide Inhibitor of α-Synuclein Aggregation Guided by Solid-State NMR§

(2008) Jillian Madine et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

(2008) Tiago Fleming Outeiro et al.   PLoS One