Kinetic Adaptations of Myosins for Their Diverse Cellular Functions

Myosin 18A Coassembles with Nonmuscle Myosin 2 to Form Mixed Bipolar Filaments

(2015) Neil Billington et al.   CURRENT BIOLOGY

Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments

(2015) R. F. Hariadi et al.   Nature Nanotechnology

Myosin VI deafness mutation prevents the initiation of processive runs on actin

(2015) Olena Pylypenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanochemical tuning of myosin-I by the N-terminal region

(2015) Michael J. Greenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity

(2015) Donald A. Winkelmann et al.   Nature Communications

Structural dynamics of myosin 5 during processive motion revealed by interferometric scattering microscopy

(2015) Joanna Andrecka et al.   eLife

Contractility parameters of human  -cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function

(2015) S. Nag et al.   Science Advances

Cargo Recognition and Cargo-Mediated Regulation of Unconventional Myosins

(2014) Qing Lu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Drosophila Myosin-XX Functions as an Actin-Binding Protein To Facilitate the Interaction between Zyx102 and Actin

(2014) Yang Cao et al.   BIOCHEMISTRY

Inherent Force-Dependent Properties of β -Cardiac Myosin Contribute to the Force-Velocity Relationship of Cardiac Muscle

(2014) Michael J. Greenberg et al.   BIOPHYSICAL JOURNAL

Motor and Tail Homology 1 (TH1) Domains Antagonistically Control Myosin-1 Dynamics

(2014) Jessica N. Mazerik et al.   BIOPHYSICAL JOURNAL

Nonmuscle Myosin II Isoforms Coassemble in Living Cells

(2014) Jordan R. Beach et al.   CURRENT BIOLOGY

Myo19 Ensures Symmetric Partitioning of Mitochondria and Coupling of Mitochondrial Segregation to Cell Division

(2014) Jennifer L. Rohn et al.   CURRENT BIOLOGY

Endogenous Species of Mammalian Nonmuscle Myosin IIA and IIB Include Activated Monomers and Heteropolymers

(2014) Maria S. Shutova et al.   CURRENT BIOLOGY

Evolution and Classification of Myosins, a Paneukaryotic Whole-Genome Approach

(2014) Arnau Sebé-Pedrós et al.   Genome Biology and Evolution

Mouse Myosin-19 Is a Plus-end-directed, High-duty Ratio Molecular Motor

(2014) Zekuan Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Motor coupling through lipid membranes enhances transport velocities for ensembles of myosin Va

(2014) S. R. Nelson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin-10 produces its power-stroke in two phases and moves processively along a single actin filament under low load

(2014) Y. Takagi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin lever arm directs collective motion on cellular actin network

(2014) R. F. Hariadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct in Vivo RNAi Screen Unveils Myosin IIa as a Tumor Suppressor of Squamous Cell Carcinomas

(2014) D. Schramek et al.   SCIENCE

Coupling of Two Non-processive Myosin 5c Dimers Enables Processive Stepping along Actin Filaments

(2014) Laura K. Gunther et al.   Scientific Reports

ERK as a Model for Systems Biology of Enzyme Kinetics in Cells

(2013) Alan S. Futran et al.   CURRENT BIOLOGY

Biochemical and bioinformatic analysis of the myosin-XIX motor domain

(2013) Rebecca C. Adikes et al.   Cytoskeleton

The Superfast Human Extraocular Myosin Is Kinetically Distinct from the Fast Skeletal IIa, IIb, and IId Isoforms

(2013) Marieke J. Bloemink et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Characterization of Human Myosin-18A and Its Interaction with F-actin and GOLPH3

(2013) Manuel H. Taft et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

More Than Just a Cargo Adapter, Melanophilin Prolongs and Slows Processive Runs of Myosin Va

(2013) Maria Sckolnick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Myosin-18A, a Highly Divergent Myosin

(2013) Stephanie Guzik-Lendrum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Three Full-length Human Nonmuscle Myosin II Paralogs

(2013) Neil Billington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin

(2013) Vanesa M. Tomatis et al.   JOURNAL OF CELL BIOLOGY

Myosin VI and its cargo adaptors - linking endocytosis and autophagy

(2013) D. A. Tumbarello et al.   JOURNAL OF CELL SCIENCE

Single-molecule reconstitution of mRNA transport by a class V myosin

(2013) Thomas E Sladewski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of the relaxed state of a Ca2+-regulated myosin filament and its evolutionary implications

(2013) J. L. Woodhead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Directing exocrine secretory vesicles to the apical membrane by actin cables generated by the formin mDia1

(2013) E. Geron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium Regulation of Myosin-I Tension Sensing

(2012) John H. Lewis et al.   BIOPHYSICAL JOURNAL

Myosin IIIB Uses an Actin-Binding Motif in Its Espin-1 Cargo to Reach the Tips of Actin Protrusions

(2012) Raymond C. Merritt et al.   CURRENT BIOLOGY

Kinetic properties and small-molecule inhibition of human myosin-6

(2012) Sarah M. Heissler et al.   FEBS LETTERS

Collective Dynamics of Elastically Coupled Myosin V Motors

(2012) Hailong Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic Characterization of Nonmuscle Myosin IIB at the Single Molecule Level

(2012) Attila Nagy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The myosin superfamily at a glance

(2012) M. A. Hartman et al.   JOURNAL OF CELL SCIENCE

Myosin IC generates power over a range of loads via a new tension-sensing mechanism

(2012) M. J. Greenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanics of Cardiac Myosin-Binding Protein C in Native Thick Filaments

(2012) M. J. Previs et al.   SCIENCE

Regulation and control of myosin-I by the motor and light chain-binding domains

(2012) Michael J. Greenberg et al.   TRENDS IN CELL BIOLOGY

A Hearing Loss-Associated myo1c Mutation (R156W) Decreases the Myosin Duty Ratio and Force Sensitivity

(2011) Tianming Lin et al.   BIOCHEMISTRY

Detailed Tuning of Structure and Intramolecular Communication Are Dispensable for Processive Motion of Myosin VI

(2011) Mary Williard Elting et al.   BIOPHYSICAL JOURNAL

Functional characterization of the human myosin-7a motor domain

(2011) Sarah M. Heissler et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Drosophila melanogasterMyosin-18 Represents a Highly Divergent Motor with Actin Tethering Properties

(2011) Stephanie Guzik-Lendrum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Kinetic Mechanism of Mouse Myosin VIIA

(2011) Jessica Haithcock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative Kinetic and Functional Characterization of the Motor Domains of Human Nonmuscle Myosin-2C Isoforms

(2011) Sarah M. Heissler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Insert-1 of Myosin VI in Modulating Nucleotide Affinity

(2011) Olena Pylypenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the Tail in the Regulated State of Myosin 2

(2011) Hyun Suk Jung et al.   JOURNAL OF MOLECULAR BIOLOGY

Myosin 1b promotes the formation of post-Golgi carriers by regulating actin assembly and membrane remodelling at the trans-Golgi network

(2011) Claudia G. Almeida et al.   NATURE CELL BIOLOGY

Phospholipid-dependent regulation of the motor activity of myosin X

(2011) Nobuhisa Umeki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transport

(2011) M. Y. Ali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cargo binding activates myosin VIIA motor function in cells

(2011) T. Sakai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct evidence for functional smooth muscle myosin II in the 10S self-inhibited monomeric conformation in airway smooth muscle cells

(2011) D. L. Milton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of MyTH4-FERM Domains in Myosin VIIa Tail Bound to Cargo

(2011) L. Wu et al.   SCIENCE

Shaking the myosin family tree: Biochemical kinetics defines four types of myosin motor

(2011) Marieke J. Bloemink et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PtdIns(3,4,5)P3 is a regulator of myosin-X localization and filopodia formation

(2010) L. Plantard et al.   JOURNAL OF CELL SCIENCE

Robust Mechanosensing and Tension Generation by Myosin VI

(2010) Peiying Chuan et al.   JOURNAL OF MOLECULAR BIOLOGY

Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane

(2010) Lisa M. Bond et al.   MOLECULAR BIOLOGY OF THE CELL

Myosin-Va transports the endoplasmic reticulum into the dendritic spines of Purkinje neurons

(2010) Wolfgang Wagner et al.   NATURE CELL BIOLOGY

Single-molecule stepping and structural dynamics of myosin X

(2010) Yujie Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Random Walk of Processive, Quantum Dot-Labeled Myosin Va Molecules within the Actin Cortex of COS-7 Cells

(2009) Shane R. Nelson et al.   BIOPHYSICAL JOURNAL

GOLPH3 Bridges Phosphatidylinositol-4- Phosphate and Actomyosin to Stretch and Shape the Golgi to Promote Budding

(2009) Holly C. Dippold et al.   CELL

Myosin VI Undergoes Cargo-Mediated Dimerization

(2009) Cong Yu et al.   CELL

A Novel Form of Motility in Filopodia Revealed by Imaging Myosin-X at the Single-Molecule Level

(2009) Michael L. Kerber et al.   CURRENT BIOLOGY

Human Myo19 Is a Novel Myosin that Associates with Mitochondria

(2009) Omar A. Quintero et al.   CURRENT BIOLOGY

Coupled myosin VI motors facilitate unidirectional movement on an F-actin network

(2009) Sivaraj Sivaramakrishnan et al.   JOURNAL OF CELL BIOLOGY

TheDictyosteliumtype V myosin MyoJ is responsible for the cortical association and motility of contractile vacuole membranes

(2009) Goeh Jung et al.   JOURNAL OF CELL BIOLOGY

Myosin VI Dimerization Triggers an Unfolding of a Three-Helix Bundle in Order to Extend Its Reach

(2009) Monalisa Mukherjea et al.   MOLECULAR CELL

Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments

(2009) Felipe T. Salles et al.   NATURE CELL BIOLOGY

The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIA

(2009) N. Umeki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of myosin-I force sensing by alternative splicing

(2009) J. M. Laakso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The SAH domain extends the functional length of the myosin lever

(2009) Thomas G. Baboolal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A FERM domain autoregulates Drosophila myosin 7a activity

(2009) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cargo binding induces dimerization of myosin VI

(2009) D. Phichith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The class V myosin motor, myosin 5c, localizes to mature secretory vesicles and facilitates exocytosis in lacrimal acini

(2008) Ronald R. Marchelletta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth

(2008) G. Lefevre et al.   DEVELOPMENT

DictyosteliumMyosin-5b Is a Conditional Processive Motor

(2008) Manuel H. Taft et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-Dimensional Reconstruction of Tarantula Myosin Filaments Suggests How Phosphorylation May Regulate Myosin Activity

(2008) Lorenzo Alamo et al.   JOURNAL OF MOLECULAR BIOLOGY

Head–Head Interaction Characterizes the Relaxed State of Limulus Muscle Myosin Filaments

(2008) Fa-Qing Zhao et al.   JOURNAL OF MOLECULAR BIOLOGY

Direct observation of the mechanochemical coupling in myosin Va during processive movement

(2008) Takeshi Sakamoto et al.   NATURE

Load-dependent ADP binding to myosins V and VI: Implications for subunit coordination and function

(2008) Y. Oguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin I Can Act As a Molecular Force Sensor

(2008) J. M. Laakso et al.   SCIENCE

A Myo6 Mutation Destroys Coordination between the Myosin Heads, Revealing New Functions of Myosin VI in the Stereocilia of Mammalian Inner Ear Hair Cells

(2008) Ronna Hertzano et al.   PLoS Genetics