The Emerging Role of Cohesin in the DNA Damage Response

Establishment of DNA-DNA Interactions by the Cohesin Ring

(2018) Yasuto Murayama et al.   CELL

The Energetics and Physiological Impact of Cohesin Extrusion

(2018) Laura Vian et al.   CELL

Repair of DNA double-strand breaks by mammalian alternative end-joining pathways

(2018) Annahita Sallmyr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Scc2 Is a Potent Activator of Cohesin’s ATPase that Promotes Loading by Binding Scc1 without Pds5

(2018) Naomi J. Petela et al.   MOLECULAR CELL

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization

(2018) Aleksandar Kojic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization

(2018) Aleksandar Kojic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion

(2018) Ge Zheng et al.   eLife

Error‐free DNA damage tolerance pathway is facilitated by the Irc5 translocase through cohesin

(2018) Ireneusz Litwin et al.   EMBO JOURNAL

Cohesin SA2 is a sequence-independent DNA-binding protein that recognizes DNA replication and repair intermediates

(2017) Preston Countryman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage

(2017) Christopher Bot et al.   JOURNAL OF CELL SCIENCE

Smc3 Deacetylation by Hos1 Facilitates Efficient Dissolution of Sister Chromatid Cohesion during Early Anaphase

(2017) Shuyu Li et al.   MOLECULAR CELL

Structural Basis of Mec1-Ddc2-RPA Assembly and Activation on Single-Stranded DNA at Sites of Damage

(2017) Ishan Deshpande et al.   MOLECULAR CELL

Cohesin Ubiquitylation and Mobilization Facilitate Stalled Replication Fork Dynamics

(2017) Camilla Frattini et al.   MOLECULAR CELL

The LSH/HELLS homolog Irc5 contributes to cohesin association with chromatin in yeast

(2017) Ireneusz Litwin et al.   NUCLEIC ACIDS RESEARCH

Esco1 and Esco2 regulate distinct cohesin functions during cell cycle progression

(2017) Reem M. Alomer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the cohesin loader Scc2

(2017) William C. H. Chao et al.   Nature Communications

Scc2/Nipbl hops between chromosomal cohesin rings after loading

(2017) James Rhodes et al.   eLife

Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops

(2017) Jie Liu et al.   eLife

The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer

(2017) et al.   Cancers

CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation

(2016) Matthias Merkenschlager et al.   Annual Review of Genomics and Human Genetics

Mechanism and regulation of DNA end resection in eukaryotes

(2016) Lorraine S. Symington   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

DNA damage tolerance by recombination: Molecular pathways and DNA structures

(2016) Dana Branzei et al.   DNA REPAIR

Rapid movement and transcriptional re‐localization of human cohesin on DNA

(2016) Iain F Davidson et al.   EMBO JOURNAL

Cohesin Releases DNA through Asymmetric ATPase-Driven Ring Opening

(2016) Ahmed M.O. Elbatsh et al.   MOLECULAR CELL

Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome

(2016) Catarina P. Samora et al.   MOLECULAR CELL

The Cohesin Complex Prevents the End Joining of Distant DNA Double-Strand Ends

(2016) Camille Gelot et al.   MOLECULAR CELL

RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together

(2016) Andrew Seeber et al.   MOLECULAR CELL

Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction

(2016) Anthony M. Couturier et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy

(2016) Sotaro Kikuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into Ring Formation of Cohesin and Related Smc Complexes

(2016) Thomas Gligoris et al.   TRENDS IN CELL BIOLOGY

Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function

(2016) Kyle W. Muir et al.   Cell Reports

Multiomic Analysis of the UV-Induced DNA Damage Response

(2016) Stefan Boeing et al.   Cell Reports

Evidence for cohesin sliding along budding yeast chromosomes

(2016) Maria Ocampo-Hafalla et al.   Open Biology

DNA Entry into and Exit out of the Cohesin Ring by an Interlocking Gate Mechanism

(2015) Yasuto Murayama et al.   CELL

Genetic Inactivation ofATRXLeads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells

(2015) Rita Eid et al.   MOLECULAR AND CELLULAR BIOLOGY

Error-Free DNA Damage Tolerance and Sister Chromatid Proximity during DNA Replication Rely on the Polα/Primase/Ctf4 Complex

(2015) Marco Fumasoni et al.   MOLECULAR CELL

Top3-Rmi1 Dissolve Rad51-Mediated D Loops by a Topoisomerase-Based Mechanism

(2015) Clare L. Fasching et al.   MOLECULAR CELL

Base triplet stepping by the Rad51/RecA family of recombinases

(2015) J. Y. Lee et al.   SCIENCE

Structural Studies Reveal the Functional Modularity of the Scc2-Scc4 Cohesin Loader

(2015) William C.H. Chao et al.   Cell Reports

The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering

(2015) Gamze Çamdere et al.   eLife

Structural evidence for Scc4-dependent localization of cohesin loading

(2015) Stephen M Hinshaw et al.   eLife

Suppression of Allelic Recombination and Aneuploidy by Cohesin Is Independent of Chk1 in Saccharomyces cerevisiae

(2015) Shay Covo et al.   PLoS One

Pds5 Prevents the PolySUMO-Dependent Separation of Sister Chromatids

(2014) Lisa M. D’Ambrosio et al.   CURRENT BIOLOGY

Holliday junction resolution: Regulation in space and time

(2014) Joao Matos et al.   DNA REPAIR

DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity

(2014) V. Gonzalez-Huici et al.   EMBO JOURNAL

Structure and function of cohesin's Scc3/SA regulatory subunit

(2014) Maurici B. Roig et al.   FEBS LETTERS

A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication

(2014) D. Gritenaite et al.   GENES & DEVELOPMENT

Chromosome Segregation in Budding Yeast: Sister Chromatid Cohesion and Related Mechanisms

(2014) Adele L. Marston   GENETICS

Rad54 Functions as a Heteroduplex DNA Pump Modulated by Its DNA Substrates and Rad51 during D Loop Formation

(2014) William Douglass Wright et al.   MOLECULAR CELL

The Scc2–Scc4 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions

(2014) Lidia Lopez-Serra et al.   NATURE GENETICS

Visualization of recombination-mediated damage bypass by template switching

(2014) Michele Giannattasio et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell cycle-specific cleavage of Scc2 regulates its cohesin deposition activity

(2014) J. Woodman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Closing the cohesin ring: Structure and function of its Smc3-kleisin interface

(2014) T. G. Gligoris et al.   SCIENCE

The Dissolution of Double Holliday Junctions

(2014) A. H. Bizard et al.   Cold Spring Harbor Perspectives in Biology

Rad5 Plays a Major Role in the Cellular Response to DNA Damage during Chromosome Replication

(2014) María Ángeles Ortiz-Bazán et al.   Cell Reports

A Cohesin-Independent Role for NIPBL at Promoters Provides Insights in CdLS

(2014) Jessica Zuin et al.   PLoS Genetics

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

(2014) Mireille Bétermier et al.   PLoS Genetics

Chromatin Movement in the Maintenance of Genome Stability

(2013) Vincent Dion et al.   CELL

An Eco1-independent sister chromatid cohesion establishment pathway in S. cerevisiae

(2013) Vanessa Borges et al.   CHROMOSOMA

Cohesin-Dependent Association of Scc2/4 with the Centromere Initiates Pericentromeric Cohesion Establishment

(2013) Josefin Fernius et al.   CURRENT BIOLOGY

Cohesin in development and disease

(2013) S. Remeseiro et al.   DEVELOPMENT

Structural insights into the regulation of cohesion establishment by Wpl1

(2013) Avradip Chatterjee et al.   EMBO JOURNAL

Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover

(2013) Barnabas Szakal et al.   EMBO JOURNAL

Cohesin and the nucleolus constrain the mobility of spontaneous repair foci

(2013) Vincent Dion et al.   EMBO REPORTS

A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination

(2013) Elin Enervald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Replication Stress-Induced Genome Instability: The Dark Side of Replication Maintenance by Homologous Recombination

(2013) Antony M. Carr et al.   JOURNAL OF MOLECULAR BIOLOGY

Distinct Functions of Human Cohesin-SA1 and Cohesin-SA2 in Double-Strand Break Repair

(2013) X. Kong et al.   MOLECULAR AND CELLULAR BIOLOGY

The Preference for Error-Free or Error-Prone Postreplication Repair in Saccharomyces cerevisiae Exposed to Low-Dose Methyl Methanesulfonate Is Cell Cycle Dependent

(2013) D. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Biochemical reconstitution of topological DNA binding by the cohesin ring

(2013) Yasuto Murayama et al.   NATURE

Effect of nuclear architecture on the efficiency of double-strand break repair

(2013) Neta Agmon et al.   NATURE CELL BIOLOGY

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Pds5 promotes and protects cohesin acetylation

(2013) K.-L. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells

(2013) J. Zuin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importance of Polη for Damage-Induced Cohesion Reveals Differential Regulation of Cohesion Establishment at the Break Site and Genome-Wide

(2013) Elin Enervald et al.   PLoS Genetics

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

(2013) Fernando Gómez-Herreros et al.   PLoS Genetics

Cohesin’s DNA Exit Gate Is Distinct from Its Entrance Gate and Is Regulated by Acetylation

(2012) Kok-Lung Chan et al.   CELL

SUMOylation of the α-Kleisin Subunit of Cohesin Is Required for DNA Damage-Induced Cohesion

(2012) Alexandra McAleenan et al.   CURRENT BIOLOGY

A SUMO-Dependent Step during Establishment of Sister Chromatid Cohesion

(2012) Seba Almedawar et al.   CURRENT BIOLOGY

Replication stress and genome rearrangements: lessons from yeast models

(2012) Sarah Lambert et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer

(2012) Rachel Brough et al.   EMBO JOURNAL

Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl

(2012) N. Wu et al.   GENES & DEVELOPMENT

Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs

(2012) Shruti Malu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cohesin Association to Replication Sites Depends on Rad50 and Promotes Fork Restart

(2012) Mireille Tittel-Elmer et al.   MOLECULAR CELL

Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin

(2012) Alexandra McAleenan et al.   NATURE

Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks

(2012) Pierre Caron et al.   PLoS Genetics

Cohesin Rings Devoid of Scc3 and Pds5 Maintain Their Stable Association with the DNA

(2012) Irina Kulemzina et al.   PLoS Genetics

SMC1A codon 496 mutations affect the cellular response to genotoxic treatments

(2011) Linda Mannini et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Recruitment of the cohesin loading factor NIPBL to DNA double-strand breaks depends on MDC1, RNF168 and HP1γ in human cells

(2011) Yasuyoshi Oka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction

(2011) Diana Braunholz et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

RSC Facilitates Rad59-Dependent Homologous Recombination between Sister Chromatids by Promoting Cohesin Loading at DNA Double-Strand Breaks

(2011) J.-H. Oum et al.   MOLECULAR AND CELLULAR BIOLOGY

Cohesin-independent segregation of sister chromatids in budding yeast

(2011) Vincent Guacci et al.   MOLECULAR BIOLOGY OF THE CELL

Sororin Mediates Sister Chromatid Cohesion by Antagonizing Wapl

(2010) Tomoko Nishiyama et al.   CELL

The RAD6 DNA Damage Tolerance Pathway Operates Uncoupled from the Replication Fork and Is Functional Beyond S Phase

(2010) Georgios I. Karras et al.   CELL

PCNA is ubiquitinated by RNF8

(2010) Sufang Zhang et al.   CELL CYCLE

Systematic Reduction of Cohesin Differentially Affects Chromosome Segregation, Condensation, and DNA Repair

(2010) Jill M. Heidinger-Pauli et al.   CURRENT BIOLOGY

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

Genome-wide Reinforcement of Cohesin Binding at Pre-existing Cohesin Sites in Response to Ionizing Radiation in Human Cells

(2010) Beom-Jun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dosage-Sensitive Regulation of Cohesin Chromosome Binding and Dynamics by Nipped-B, Pds5, and Wapl

(2010) M. Gause et al.   MOLECULAR AND CELLULAR BIOLOGY

Hos1 Deacetylates Smc3 to Close the Cohesin Acetylation Cycle

(2010) Vanessa Borges et al.   MOLECULAR CELL

CRL4Cdt2 E3 Ubiquitin Ligase Monoubiquitinates PCNA to Promote Translesion DNA Synthesis

(2010) Kenta Terai et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Ubiquitin-dependent DNA damage bypass is separable from genome replication

(2010) Yasukazu Daigaku et al.   NATURE

Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends

(2010) Steven A. Roberts et al.   NATURE

Mediator and cohesin connect gene expression and chromatin architecture

(2010) Michael H. Kagey et al.   NATURE

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

(2010) Mary Ellen Moynahan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Replication and Recombination Factors Contributing to Recombination-Dependent Bypass of DNA Lesions by Template Switch

(2010) Fabio Vanoli et al.   PLoS Genetics

Cohesin Is Limiting for the Suppression of DNA Damage–Induced Recombination between Homologous Chromosomes

(2010) Shay Covo et al.   PLoS Genetics

DNA Repair in Mammalian Cells

(2009) B. Pardo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells

(2009) Erwan Watrin et al.   EMBO JOURNAL

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

(2009) Andrea Beucher et al.   EMBO JOURNAL

Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination

(2009) R. Prakash et al.   GENES & DEVELOPMENT

The Dot1 Histone Methyltransferase and the Rad9 Checkpoint Adaptor Contribute to Cohesin-Dependent Double-Strand Break Repair by Sister Chromatid Recombination in Saccharomyces cerevisiae

(2009) F. Conde et al.   GENETICS

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Distinct Targets of the Eco1 Acetyltransferase Modulate Cohesion in S Phase and in Response to DNA Damage

(2009) Jill M. Heidinger-Pauli et al.   MOLECULAR CELL

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin

(2009) C. Bauerschmidt et al.   NUCLEIC ACIDS RESEARCH

Rad52 promotes second-end DNA capture in double-stranded break repair to form complement-stabilized joint molecules

(2009) A. V. Nimonkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA

(2008) Ekaterina Revenkova et al.   HUMAN MOLECULAR GENETICS

Regulation of Intra-S Phase Checkpoint by Ionizing Radiation (IR)-dependent and IR-independent Phosphorylation of SMC3

(2008) Hao Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of ATRX leads to chromosome cohesion and congression defects

(2008) Kieran Ritchie et al.   JOURNAL OF CELL BIOLOGY

Acetylation of Smc3 by Eco1 Is Required for S Phase Sister Chromatid Cohesion in Both Human and Yeast

(2008) Jinglan Zhang et al.   MOLECULAR CELL

The Kleisin Subunit of Cohesin Dictates Damage-Induced Cohesion

(2008) Jill M. Heidinger-Pauli et al.   MOLECULAR CELL

Activation of Ubiquitin-Dependent DNA Damage Bypass Is Mediated by Replication Protein A

(2008) Adelina A. Davies et al.   MOLECULAR CELL

SUMOylation regulates Rad18-mediated template switch

(2008) Dana Branzei et al.   NATURE

The cohesin ring concatenates sister DNA molecules

(2008) Christian H. Haering et al.   NATURE

Mechanism of homologous recombination from the RecA–ssDNA/dsDNA structures

(2008) Zhucheng Chen et al.   NATURE

Single-strand break repair and genetic disease

(2008) Keith W. Caldecott   NATURE REVIEWS GENETICS

Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination

(2008) I. Unk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA