N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug

Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests

(2019) Dorota Nieoczym et al.   NEUROCHEMICAL RESEARCH

Preclinical safety and efficacy of cannabidivarin for early life seizures

(2019) Megan N. Huizenga et al.   NEUROPHARMACOLOGY

Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A

(2018) Daniëlle Copmans et al.   ACS Chemical Neuroscience

Auxiliary subunits of AMPA receptors: The discovery of a forebrain-selective antagonist, LY3130481/CERC-611

(2018) Akihiko S. Kato et al.   BIOCHEMICAL PHARMACOLOGY

Evaluation of anticonvulsant and analgesic activity of new hybrid compounds derived from N -phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and –butanamides

(2018) Anna Rapacz et al.   EPILEPSY RESEARCH

Neuropathological profile of the pentylenetetrazol (PTZ) kindling model

(2018) E. Samokhina et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

In search of antiepileptogenic treatments for post-traumatic epilepsy

(2018) Patricia G. Saletti et al.   NEUROBIOLOGY OF DISEASE

KA-11, a novel pyrrolidine-2,5-dione derived broad-spectrum anticonvulsant: its antiepileptogenic, antinociceptive properties and in vitro characterization

(2018) Katarzyna Socala et al.   ACS Chemical Neuroscience

Common psychiatric comorbidities in epilepsy: How big of a problem is it?

(2018) Jay A. Salpekar et al.   EPILEPSY & BEHAVIOR

In search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3‐(1‐alkyl‐1H‐imidazol‐5‐yl)‐1H‐indole‐5‐carboxamides, low-basicity 5-HT7 receptor agonists

(2018) Gniewomir Latacz et al.   MedChemComm

Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology

(2017) Robert S. Fisher et al.   EPILEPSIA

Development and pharmacologic characterization of the rat 6 Hz model of partial seizures

(2017) Cameron S. Metcalf et al.   EPILEPSIA

Effects of agomelatine on pentylenetetrazole-induced kindling, kindling-associated oxidative stress, and behavioral despair in mice and modulation of its actions by luzindole and 1-(m-chlorophenyl) piperazine

(2017) M. Suhaib Azim et al.   EPILEPSY & BEHAVIOR

Pharmacology of cannabinoids in the treatment of epilepsy

(2017) Tyler E. Gaston et al.   EPILEPSY & BEHAVIOR

Multifunctional Hybrid Compounds Derived from 2-(2,5-Dioxopyrrolidin-1-yl)-3-methoxypropanamides with Anticonvulsant and Antinociceptive Properties

(2017) Michał Abram et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy

(2017) Anna Rapacz et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Electroencephalographic, cognitive, and neurochemical effects of LY3130481 (CERC-611), a selective antagonist of TARP-γ8-associated AMPA receptors

(2017) Jeffrey M. Witkin et al.   NEUROPHARMACOLOGY

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

(2017) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Beneficial Combination of Lacosamide with Retigabine in Experimental Animals: An Isobolographic Analysis

(2017) Jarogniew J. Luszczki et al.   PHARMACOLOGY

Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers

(2017) Fei Tang et al.   Frontiers in Neurology

Additive Interactions between 1-Methyl-1,2,3,4-Tetrahydroisoquinoline and Clobazam in the Mouse Maximal Electroshock-Induced Tonic Seizure Model - An Isobolographic Analysis for Parallel Dose-Response Relationship Curves

(2017) Marta Andres-Mach et al.   PHARMACOLOGY

Design, synthesis and anticonvulsant activity of new hybrid compounds derived from N -phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and -butanamides

(2016) Krzysztof Kamiński et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Influence of xanthotoxin (8-methoxypsoralen) on the anticonvulsant activity of various novel antiepileptic drugs against maximal electroshock-induced seizures in mice

(2016) Mirosław Zagaja et al.   FITOTERAPIA

Neurochemical modulation involved in the beneficial effect of liraglutide, GLP-1 agonist on PTZ kindling epilepsy-induced comorbidities in mice

(2016) Prashant Koshal et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism

(2016) Akihiko S Kato et al.   NATURE MEDICINE

Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission

(2016) Kentaro Tokudome et al.   Scientific Reports

Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives

(2015) Krzysztof Kamiński et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, Synthesis, and Anticonvulsant Activity of New Hybrid Compounds Derived from 2-(2,5-Dioxopyrrolidin-1-yl)propanamides and 2-(2,5-Dioxopyrrolidin-1-yl)butanamides

(2015) Krzysztof Kamiński et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synergistic Interaction of Retigabine with Levetiracetam in the Mouse Maximal Electroshock-Induced Seizure Model: A Type II Isobolographic Analysis

(2015) Jarogniew J. Luszczki et al.   PHARMACOLOGY

Multi-target pharmacology: possibilities and limitations of the “skeleton key approach” from a medicinal chemist perspective

(2015) Alan Talevi   Frontiers in Pharmacology

Nonpsychotropic Plant Cannabinoids, Cannabidivarin (CBDV) and Cannabidiol (CBD), Activate and Desensitize Transient Receptor Potential Vanilloid 1 (TRPV1) Channels in Vitro: Potential for the Treatment of Neuronal Hyperexcitability

(2014) Fabio Arturo Iannotti et al.   ACS Chemical Neuroscience

Genetic background of mice strongly influences treatment resistance in the 6 Hz seizure model

(2014) Karine Leclercq et al.   EPILEPSIA

Multifunctional compounds: Smart molecules for multifactorial diseases

(2014) Yogita Bansal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Potential of Antiseizure Drugs and Agents that Act on Novel Molecular Targets as Antiepileptogenic Treatments

(2014) Rafal M. Kaminski et al.   Neurotherapeutics

Tanshinone IIA Exhibits Anticonvulsant Activity in Zebrafish and Mouse Seizure Models

(2013) Olivia Erin Buenafe et al.   ACS Chemical Neuroscience

Issues related to development of new antiseizure treatments

(2013) Karen S. Wilcox et al.   EPILEPSIA

Presynaptic inhibitory actions of pregabalin on excitatory transmission in superficial dorsal horn of mouse spinal cord: Further characterization of presynaptic mechanisms

(2013) Rie Matsuzawa et al.   NEUROSCIENCE LETTERS

Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs

(2013) Tatiana Afrikanova et al.   PLoS One

Insights from Zebrafish and Mouse Models on the Activity and Safety of Ar-Turmerone as a Potential Drug Candidate for the Treatment of Epilepsy

(2013) Adriana Monserrath Orellana-Paucar et al.   PLoS One

Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures

(2012) S. Baxendale et al.   Disease Models & Mechanisms

Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models

(2012) Adriana Monserrath Orellana-Paucar et al.   EPILEPSY & BEHAVIOR

Effect of ACEA—a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model

(2012) Marta Andres-Mach et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma

(2011) Wolfgang Löscher et al.   EPILEPSIA

Perampanel: A novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy

(2011) Takahisa Hanada et al.   EPILEPSIA

Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice

(2011) Jarogniew J. Luszczki et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Identification of Human Ether-à-go-go Related Gene Modulators by Three Screening Platforms in an Academic Drug-Discovery Setting

(2010) Xi-Ping Huang et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Preclinical assessment of proconvulsant drug activity and its relevance for predicting adverse events in humans

(2009) Wolfgang Löscher   EUROPEAN JOURNAL OF PHARMACOLOGY

Stress, anxiety, depression, and epilepsy: Investigating the relationship between psychological factors and seizures

(2008) Ajay Thapar et al.   EPILEPSY & BEHAVIOR

Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves

(2008) Jarogniew J. Luszczki   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY