Multi-target pharmacology: possibilities and limitations of the “skeleton key approach” from a medicinal chemist perspective
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Multi-target pharmacology: possibilities and limitations of the “skeleton key approach” from a medicinal chemist perspective
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 6, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2015-09-28
DOI
10.3389/fphar.2015.00205
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Multitasking models for quantitative structure–biological effect relationships: current status and future perspectives to speed up drug discovery
- (2015) Alejandro Speck-Planche et al. Expert Opinion on Drug Discovery
- Multi-Target Directed Drugs: A Modern Approach for Design of New Drugs for the treatment of Alzheimer’s Disease
- (2014) Kris Simone Tranches Dias et al. Current Neuropharmacology
- Multi-target approach for natural products in inflammation
- (2014) Andreas Koeberle et al. DRUG DISCOVERY TODAY
- Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases
- (2014) Kai Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- The role of ligand efficiency metrics in drug discovery
- (2014) Andrew L. Hopkins et al. NATURE REVIEWS DRUG DISCOVERY
- A Novel Multi-Target Drug Screening Strategy Directed Against Key Proteins of DAPk Family
- (2013) Syam B. Nair et al. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
- Rationally Designed Multitarget Agents Against Inflammation and Pain
- (2013) S. H. Hwang et al. CURRENT MEDICINAL CHEMISTRY
- Systems biology, complexity, and the impact on antiepileptic drug discovery
- (2013) Doru Georg Margineanu EPILEPSY & BEHAVIOR
- Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it
- (2013) Douglas B. Kell FEBS Journal
- On ‘polypharmacy’ and multi-target agents, complementary strategies for improving the treatment of depression: a comparative appraisal
- (2013) Mark J. Millan INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- New avenues for anti-epileptic drug discovery and development
- (2013) Wolfgang Löscher et al. NATURE REVIEWS DRUG DISCOVERY
- Promises of novel multi-target neuroprotective and neurorestorative drugs for Parkinson's disease
- (2013) Moussa B.H. Youdim et al. PARKINSONISM & RELATED DISORDERS
- Structure and dynamics of molecular networks: A novel paradigm of drug discovery
- (2013) Peter Csermely et al. PHARMACOLOGY & THERAPEUTICS
- Challenges and opportunities of drug repositioning
- (2013) Natalia Novac TRENDS IN PHARMACOLOGICAL SCIENCES
- Novel phytochemical–antibiotic conjugates as multitarget inhibitors of Pseudomononas aeruginosa GyrB/ParE and DHFR
- (2013) Sarinder et al. Drug Design Development and Therapy
- In VitroAnti-Trypanosoma cruzi Activity of Dronedarone, a Novel Amiodarone Derivative with an Improved Safety Profile
- (2012) Gustavo Benaim et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Applications of Connectivity Map in drug discovery and development
- (2012) Xiaoyan A. Qu et al. DRUG DISCOVERY TODAY
- CNS Drug Development – Lost in Translation?
- (2012) A. Talevi et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Novel Computational Approaches to Polypharmacology as a Means to Define Responses to Individual Drugs
- (2011) Lei Xie et al. Annual Review of Pharmacology and Toxicology
- Multi-Target-Directed Ligands in Alzheimer's Disease Treatment
- (2011) M. Bajda et al. CURRENT MEDICINAL CHEMISTRY
- Antiepileptic drug therapy: Does mechanism of action matter?
- (2011) Martin J. Brodie et al. EPILEPSY & BEHAVIOR
- In-Silico Approaches to Multi-target Drug Discovery
- (2010) Xiao Hua Ma et al. PHARMACEUTICAL RESEARCH
- Multitarget drugs: the present and the future of cancer therapy
- (2009) Annalisa Petrelli et al. EXPERT OPINION ON PHARMACOTHERAPY
- From Single- to Multi-Target Drugs in Cancer Therapy: When Aspecificity Becomes an Advantage
- (2008) S. Giordano et al. CURRENT MEDICINAL CHEMISTRY
- Benefit of combination therapy in epilepsy: A review of the preclinical evidence with levetiracetam
- (2008) Rafal M. Kaminski et al. EPILEPSIA
- From ion channels to complex networks: Magic bullet versus magic shotgun approaches to anticonvulsant pharmacotherapy
- (2008) Matt T. Bianchi et al. MEDICAL HYPOTHESES
- Network pharmacology: the next paradigm in drug discovery
- (2008) Andrew L Hopkins Nature Chemical Biology
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started