Connecting the nucleolus to the cell cycle and human disease

Targeting the nucleolus for cancer intervention

(2014) Jaclyn E. Quin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

(2014) Karita Peltonen et al.   CANCER CELL

Nucleostemin and GNL3L exercise distinct functions in genome protection and ribosome synthesis, respectively

(2014) Tao Lin et al.   JOURNAL OF CELL SCIENCE

Nucleolar Organization, Ribosomal DNA Array Stability, and Acrocentric Chromosome Integrity Are Linked to Telomere Function

(2014) Kaitlin M. Stimpson et al.   PLoS One

Changes in rRNA Transcription Influence Proliferation and Cell Fate Within a Stem Cell Lineage

(2014) Q. Zhang et al.   SCIENCE

Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis

(2013) Sladana Bursac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Functional ribosome biogenesis is a prerequisite for p53 destabilization: impact of chemotherapy on nucleolar functions and RNA metabolism

(2013) Kaspar Burger et al.   BIOLOGICAL CHEMISTRY

Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy

(2013) Nikolina Vlatković et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A novel role of nucleostemin in maintaining the genome integrity of dividing hepatocytes during mouse liver development and regeneration

(2013) Tao Lin et al.   HEPATOLOGY

Old Drug, New Target

(2013) William J. Andrews et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nucleolus stress response is coupled to an ATR-Chk1–mediated G2 arrest

(2013) Hanhui Ma et al.   MOLECULAR BIOLOGY OF THE CELL

DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1

(2013) Anne S. Calkins et al.   NUCLEIC ACIDS RESEARCH

Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells

(2013) L. Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nucleolus: an emerging target for cancer therapy

(2013) Nadine Hein et al.   TRENDS IN MOLECULAR MEDICINE

The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress

(2013) Katherine E. Sloan et al.   Cell Reports

Dysregulation of RNA polymerase I transcription during disease

(2012) K.M. Hannan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint

(2012) S. Fumagalli et al.   GENES & DEVELOPMENT

Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1

(2012) Joseph K. Hsu et al.   JOURNAL OF CELL BIOLOGY

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

(2012) S. Bursac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleolar Localization of a Netrin-1 Isoform Enhances Tumor Cell Proliferation

(2012) C. Delloye-Bourgeois et al.   Science Signaling

Nuclear ErbB2 Enhances Translation and Cell Growth by Activating Transcription of Ribosomal RNA Genes

(2011) L.-Y. Li et al.   CANCER RESEARCH

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

(2011) J. C. Chan et al.   Science Signaling

The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

(2010) Denis Drygin et al.   Annual Review of Pharmacology and Toxicology

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

(2010) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway

(2010) C Deisenroth et al.   ONCOGENE

Identification of Novel p53 Pathway Activating Small-Molecule Compounds Reveals Unexpected Similarities with Known Therapeutic Agents

(2010) Karita Peltonen et al.   PLoS One

The Nucleolus

(2010) T. Pederson   Cold Spring Harbor Perspectives in Biology

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

What the nucleolus says to a tumour pathologist

(2009) Massimo Derenzini et al.   HISTOPATHOLOGY

In search of nonribosomal nucleolar protein function and regulation

(2009) Thoru Pederson et al.   JOURNAL OF CELL BIOLOGY

How Common Are Extraribosomal Functions of Ribosomal Proteins?

(2009) Jonathan R. Warner et al.   MOLECULAR CELL

AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply

(2009) S. Hoppe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Haploinsufficiency of RPS14 in 5q− syndrome is associated with deregulation of ribosomal- and translation-related genes

(2008) Andrea Pellagatti et al.   BRITISH JOURNAL OF HAEMATOLOGY

Perinucleolar compartment prevalence is a phenotypic pancancer marker of malignancy

(2008) John T. Norton et al.   CANCER