The biogenesis of chromosome translocations

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

Chromatin Remodeling at DNA Double-Strand Breaks

(2013) Brendan D. Price et al.   CELL

Chromatin Movement in the Maintenance of Genome Stability

(2013) Vincent Dion et al.   CELL

Molecular Pathways: Transcription Factories and Chromosomal Translocations

(2013) C. S. Osborne   CLINICAL CANCER RESEARCH

The cellular etiology of chromosome translocations

(2013) Vassilis Roukos et al.   CURRENT OPINION IN CELL BIOLOGY

Cohesin and the nucleolus constrain the mobility of spontaneous repair foci

(2013) Vincent Dion et al.   EMBO REPORTS

Checkpoint kinases and the INO80 nucleosome remodeling complex enhance global chromatin mobility in response to DNA damage

(2013) A. Seeber et al.   GENES & DEVELOPMENT

Monitoring Homology Search during DNA Double-Strand Break Repair In Vivo

(2013) Jörg Renkawitz et al.   MOLECULAR CELL

Effect of nuclear architecture on the efficiency of double-strand break repair

(2013) Neta Agmon et al.   NATURE CELL BIOLOGY

Spatial Dynamics of Chromosome Translocations in Living Cells

(2013) V. Roukos et al.   SCIENCE

Spatial Organization of the Mouse Genome and Its Role in Recurrent Chromosomal Translocations

(2012) Yu Zhang et al.   CELL

Targeted INO80 enhances subnuclear chromatin movement and ectopic homologous recombination

(2012) F. R. Neumann et al.   GENES & DEVELOPMENT

Chromatin mobility is increased at sites of DNA double-strand breaks

(2012) P. M. Krawczyk et al.   JOURNAL OF CELL SCIENCE

Close Proximity to Igh Is a Contributing Factor to AID-Mediated Translocations

(2012) Pedro P. Rocha et al.   MOLECULAR CELL

Prime, Repair, Restore: The Active Role of Chromatin in the DNA Damage Response

(2012) Gaston Soria et al.   MOLECULAR CELL

Single-molecule imaging of DNA pairing by RecA reveals a three-dimensional homology search

(2012) Anthony L. Forget et al.   NATURE

Increased chromosome mobility facilitates homology search during recombination

(2012) Judith Miné-Hattab et al.   NATURE CELL BIOLOGY

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery

(2012) Vincent Dion et al.   NATURE CELL BIOLOGY

Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration

(2012) Colby Chiang et al.   NATURE GENETICS

Homologous chromosomes make contact at the sites of double-strand breaks in genes in somatic G0/G1-phase human cells

(2012) M. Gandhi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes

(2012) L. Kato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constitutional Chromothripsis Rearrangements Involve Clustered Double-Stranded DNA Breaks and Nonhomologous Repair Mechanisms

(2012) Wigard P. Kloosterman et al.   Cell Reports

RecA filament sliding on DNA facilitates homology search

(2012) Kaushik Ragunathan et al.   eLife

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

(2011) Irene Chiolo et al.   CELL

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic Rearrangements

(2011) Pengfei Liu et al.   CELL

Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes

(2011) Isaac A. Klein et al.   CELL

Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

(2011) Roberto Chiarle et al.   CELL

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

(2011) Zhiyong Mao et al.   CELL CYCLE

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

Human Mre11/Human Rad50/Nbs1 and DNA Ligase IIIα/XRCC1 Protein Complexes Act Together in an Alternative Nonhomologous End Joining Pathway

(2011) Julie Della-Maria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Principles of chromosomal organization: lessons from yeast

(2011) Christophe Zimmer et al.   JOURNAL OF CELL BIOLOGY

Choosing the right path: Does DNA-PK help make the decision?

(2011) Jessica A. Neal et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The genomic complexity of primary human prostate cancer

(2011) Michael F. Berger et al.   NATURE

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

(2011) Jiri Lukas et al.   NATURE CELL BIOLOGY

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin

(2011) Burkhard Jakob et al.   NUCLEIC ACIDS RESEARCH

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

(2011) Deniz Simsek et al.   PLoS Genetics

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation

(2010) Tracey A. Dobbs et al.   DNA REPAIR

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

(2010) Cristian Boboila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4–ligase IV during chromosomal translocation formation

(2010) Deniz Simsek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

(2010) Yu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Budding Yeast Nucleus

(2010) A. Taddei et al.   Cold Spring Harbor Perspectives in Biology

The Dangers of Transcription

(2009) Stephan Mathas et al.   CELL

Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer

(2009) Chunru Lin et al.   CELL

Chromatin dynamics is correlated with replication timing

(2009) Artem Pliss et al.   CHROMOSOMA

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

(2009) Beth A. Helmink et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of change in gene copy number

(2009) P. J. Hastings et al.   NATURE REVIEWS GENETICS

The emerging role of nuclear architecture in DNA repair and genome maintenance

(2009) Tom Misteli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multiple functions of MRN in end-joining pathways during isotype class switching

(2009) Maria Dinkelmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

(2009) Anyong Xie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

(2009) Emilie Rass et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Live cell microscopy analysis of radiation-induced DNA double-strand break motion

(2009) B. Jakob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma

(2009) S. Mathas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation

(2009) P. J. Hastings et al.   PLoS Genetics

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

(2008) Nadya Dimitrova et al.   NATURE

A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

(2008) Aude Dupré et al.   Nature Chemical Biology

Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks

(2008) L. Liang et al.   NUCLEIC ACIDS RESEARCH

Segmental Duplications Arise from Pol32-Dependent Repair of Broken Forks through Two Alternative Replication-Based Mechanisms

(2008) Celia Payen et al.   PLoS Genetics

Chromatin movement visualized with photoactivable GFP-labeled histone H4

(2007) Karien Wiesmeijer et al.   DIFFERENTIATION