Ursolic and Oleanolic Acids Induce Mitophagy in A549 Human Lung Cancer Cells

Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity

(2019) Yulin Ren et al.   PLANTA MEDICA

Mechanisms of PINK1, ubiquitin and Parkin interactions in mitochondrial quality control and beyond

(2019) Andrew N. Bayne et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives

(2018) Yulin Ren et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Involvement of PINK1/Parkin-mediated mitophagy in paraquat- induced apoptosis in human lung epithelial-like A549 cells

(2018) Da-Zhuang Sun et al.   TOXICOLOGY IN VITRO

No Parkin Zone: Mitophagy without Parkin

(2018) Elodie Villa et al.   TRENDS IN CELL BIOLOGY

Roles of Nrf2/HO-1 and HIF-1α/VEGF in lung tissue injury and repair following cerebral ischemia/reperfusion injury

(2018) Jianhua Fan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Synthesis and Evaluation of Anticancer Activities of Novel C-28 Guanidine-Functionalized Triterpene Acid Derivatives

(2018) Anna Spivak et al.   MOLECULES

Reactive oxygen species trigger Parkin/PINK1 pathway–dependent mitophagy by inducing mitochondrial recruitment of Parkin

(2017) Bin Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ursolic acid inhibits breast cancer growth by inhibiting proliferation, inducing autophagy and apoptosis, and suppressing inflammatory responses via the PI3K/AKT and NF-κB signaling pathways in vitro

(2017) Juan Luo et al.   Experimental and Therapeutic Medicine

Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells

(2017) Elodie Villa et al.   Cell Reports

Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy

(2017) Chunjuan Song et al.   PLoS One

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anticancer and apoptotic activities of oleanolic acid are mediated through cell cycle arrest and disruption of mitochondrial membrane potential in HepG2 human hepatocellular carcinoma cells

(2015) YUE-YONG ZHU et al.   Molecular Medicine Reports

Expression pattern of parkin isoforms in lung adenocarcinomas

(2015) Agata Grazia D’Amico et al.   TUMOR BIOLOGY

Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway

(2015) Xuechao Li et al.   TUMOR BIOLOGY

The role of autophagy in bacterial infections

(2015) Nayeli Shantal Castrejón-Jiménez et al.   BioScience Trends

Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells

(2015) Huaifeng Li et al.   Drug Design Development and Therapy

Mitochondrial reactive oxygen species production mediates ursolic acid-induced mitochondrial uncoupling and glutathione redox cycling, with protection against oxidant injury in H9c2 cells

(2015) Jihang Chen et al.   Food & Function

Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells

(2015) Seong-Hoon Kim et al.   Scientific Reports

Ursolic Acid Attenuates Diabetic Mesangial Cell Injury through the Up-Regulation of Autophagy via miRNA-21/PTEN/Akt/mTOR Suppression

(2015) Xinxing Lu et al.   PLoS One

Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress

(2014) Shuying Shen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway

(2014) Jia Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy

(2014) Jia Liu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Ursolic Acid-Enriched Herba Cynomorii Extract Induces Mitochondrial Uncoupling and Glutathione Redox Cycling Through Mitochondrial Reactive Oxygen Species Generation: Protection Against Menadione Cytotoxicity in H9c2 Cells

(2014) Jihang Chen et al.   MOLECULES

Differential involvement of mitochondria during ursolic acid-induced apoptotic process in HaCaT and M4Beu cells

(2014) Raphaël Duval et al.   ONCOLOGY REPORTS

Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways

(2014) JIA LIU et al.   ONCOLOGY REPORTS

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK–p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

(2013) Xin Wang et al.   CARCINOGENESIS

Ursolic acid promotes cancer cell death by inducing Atg5-dependent autophagy

(2013) Shuilong Leng et al.   INTERNATIONAL JOURNAL OF CANCER

Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells

(2012) Chong Zhao et al.   Autophagy

Oleanolic acid arrests cell cycle and induces apoptosis via ROS-mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells

(2012) Jianteng Wei et al.   JOURNAL OF APPLIED TOXICOLOGY

Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells

(2012) Cristina P.R. Xavier et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control

(2011) Derek P. Narendra et al.   ANTIOXIDANTS & REDOX SIGNALING

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

(2011) Subash C. Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy inhibition enhances ursolic acid-induced apoptosis in PC3 cells

(2011) Seoung Woo Shin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells

(2011) Euphemia Leung et al.   CANCER BIOLOGY & THERAPY

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

(2011) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

Oleanolic Acid Initiates Apoptosis in Non-Small Cell Lung Cancer Cell Lines and Reduces Metastasis of a B16F10 Melanoma Model In Vivo

(2011) Kelly Araújo Lúcio et al.   PLoS One

Oleanolic Acid and Ursolic Acid Induce Apoptosis in HuH7 Human Hepatocellular Carcinoma Cells through a Mitochondrial-Dependent Pathway and Downregulation of XIAP

(2010) Ming-Huan Shyu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro

(2010) Yuxi Zhang et al.   MOLECULAR CARCINOGENESIS

Mitochondrial Reactive Oxygen Species Production in Excitable Cells: Modulators of Mitochondrial and Cell Function

(2009) David F. Stowe et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy in tumour suppression and promotion

(2009) Andreas Brech et al.   Molecular Oncology