Perspective on the Therapeutics of Anti-Snake Venom

The timing is right to end snakebite deaths in South Asia

(2019) Ravikar Ralph et al.   BMJ-British Medical Journal

Inhibitory effects of Morus nigra L. (Moraceae) against local paw edema and mechanical hypernociception induced by Bothrops jararacussu snake venom in mice

(2019) Anita Eugênia Alencar Santos Ribeiro et al.   BIOMEDICINE & PHARMACOTHERAPY

The Urgent Need to Develop Novel Strategies for the Diagnosis and Treatment of Snakebites

(2019) Williams et al.   Toxins

Betulinic, oleanolic and ursolic acids inhibit the enzymatic and biological effects induced by a P-I snake venom metalloproteinase

(2018) Lina María Preciado et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Anti- Deinagkistrodon acutus venom properties of ethanolic root extract from Cynanchum paniculatum (Bunge) kitag and its GC-MS analysis

(2018) Yan Xiong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Mortality due to snakebite and other venomous animals in the Indian state of Bihar: Findings from a representative mortality study

(2018) Rakhi Dandona et al.   PLoS One

Pros and cons of different therapeutic antibody formats for recombinant antivenom development

(2018) Andreas H. Laustsen et al.   TOXICON

Snakebite: When the Human Touch Becomes a Bad Touch

(2018) Bryan Fry   Toxins

Integrating Engineering, Manufacturing, and Regulatory Considerations in the Development of Novel Antivenoms

(2018) Andreas Laustsen et al.   Toxins

2017 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 35th Annual Report

(2018) David D. Gummin et al.   CLINICAL TOXICOLOGY

Inhibition of a Snake Venom Metalloproteinase by the Flavonoid Myricetin

(2018) Lina Preciado et al.   MOLECULES

Rutin (quercetin-3-rutinoside) modulates the hemostatic disturbances and redox imbalance induced by Bothrops jararaca snake venom in mice

(2018) Ana Teresa Azevedo Sachetto et al.   PLoS Neglected Tropical Diseases

Innovative Immunization Strategies for Antivenom Development

(2018) Erick Bermúdez-Méndez et al.   Toxins

Biosynthetic Oligoclonal Antivenom (BOA) for Snakebite and Next-Generation Treatments for Snakebite Victims

(2018) R. Kini et al.   Toxins

Latex from Tabernaemontana catharinensis (A. DC)—Apocynaceae: An alternative for the sustainable production of biologically active compounds

(2018) Carolina da Silva Menecucci et al.   INDUSTRIAL CROPS AND PRODUCTS

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence

(2017) Juliana Félix-Silva et al.   Evidence-based Complementary and Alternative Medicine

Medicinal plants used to treat snakebite in Central America: Review and assessment of scientific evidence

(2017) Peter Giovannini et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Australian Snakebite Project, 2005-2015 (ASP-20)

(2017) Christopher I Johnston et al.   MEDICAL JOURNAL OF AUSTRALIA

Aristolochic acid and its derivatives as inhibitors of snake venom L -amino acid oxidase

(2017) Payel Bhattacharjee et al.   TOXICON

Snakebite envenoming

(2017) José María Gutiérrez et al.   Nature Reviews Disease Primers

Snake venom toxins: toxicity and medicinal applications

(2016) Yau Sang Chan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Quercetin-3-O-rhamnoside from Euphorbia hirta protects against snake Venom induced toxicity

(2016) Kadiyala Gopi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy

(2016) Andreas Laustsen et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular modeling and snake venom phospholipase A 2 inhibition by phenolic compounds: Structure–activity relationship

(2016) Md. Iqbal Alam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibitory effect of pinostrobin from Renealmia alpinia, on the enzymatic and biological activities of a PLA2

(2016) Isabel Gómez-Betancur et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Isolation and characterization of bioactive compounds of Clematis gouriana Roxb. ex DC against snake venom phospholipase A2 (PLA2) computational and in vitro insights

(2016) Karthikeyan Muthusamy et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Engineering the Protein Corona of a Synthetic Polymer Nanoparticle for Broad-Spectrum Sequestration and Neutralization of Venomous Biomacromolecules

(2016) Jeffrey O’Brien et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic biology tackles global antivenom shortage

(2016) Carrie Arnold   NATURE

Understanding and confronting snakebite envenoming: The harvest of cooperation

(2016) José María Gutiérrez   TOXICON

Structures and binding studies of the complexes of phospholipase A2 with five inhibitors

(2015) Prakash Kumar Shukla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Adverse reactions to snake antivenom, and their prevention and treatment

(2015) H. Asita de Silva et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Dietary Flavonoid Aglycones and Their Glycosides: Which Show Better Biological Significance?

(2015) Jianbo Xiao   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites

(2015) Marianne Molander et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protective effect of Euphorbia hirta and its components against snake venom induced lethality

(2015) Kadiyala Gopi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effect of Diterpenes Isolated of the Marine Alga Canistrocarpus cervicornis against Some Toxic Effects of the Venom of the Bothrops jararaca Snake

(2015) Thaisa Domingos et al.   MOLECULES

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Structural Basis for the Inhibition of a Phospholipase A2-Like Toxin by Caffeic and Aristolochic Acids

(2015) Carlos A. H. Fernandes et al.   PLoS One

Nanofibrous Snake Venom Hemostat

(2015) Vivek A. Kumar et al.   ACS Biomaterials-Science & Engineering

Nanofibrous Snake Venom Hemostat

(2015) Vivek A. Kumar et al.   ACS Biomaterials Science & Engineering

Biodiversity as a Source of Bioactive Compounds Against Snakebites

(2014) Cesar Guimaraes et al.   CURRENT MEDICINAL CHEMISTRY

Inhibition of the toxic effects of Bothrops asper venom by pinostrobin, a flavanone isolated from Renealmia alpinia (Rottb.) MAAS

(2014) Isabel Gómez-Betancur et al.   JOURNAL OF ETHNOPHARMACOLOGY

Hyaluronidase, phospholipase A2 and protease inhibitory activity of plants used in traditional treatment of snakebite-induced tissue necrosis in Mali, DR Congo and South Africa

(2014) Marianne Molander et al.   JOURNAL OF ETHNOPHARMACOLOGY

In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico

(2013) Manuel Jiménez-Estrada et al.   BMC Complementary and Alternative Medicine

New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics

(2013) Si-Yuan Pan et al.   Evidence-based Complementary and Alternative Medicine

Harpalycin 2 inhibits the enzymatic and platelet aggregation activities of PrTX-III, a D49 phospholipase A2 from Bothrops pirajai venom

(2012) Rafael M Ximenes et al.   BMC Complementary and Alternative Medicine

The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part II

(2012) T.J. Schmidt et al.   CURRENT MEDICINAL CHEMISTRY

Phytopharmacology of Antiophidian Botanicals: A Review

(2012) Abhijit Dey et al.   International Journal of Pharmacology

Antiophidic activity of the extract of the Amazon plant Humirianthera ampla and constituents

(2012) Marcelo Abrahão Strauch et al.   JOURNAL OF ETHNOPHARMACOLOGY

Characterization of the aqueous extract of the root of Aristolochia indica: Evaluation of its traditional use as an antidote for snake bites

(2012) Payel Bhattacharjee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Snake Venom Induced Local Toxicities: Plant Secondary Metabolites as an Auxiliary Therapy

(2012) M. Sebastin Santhosh et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Contribution of cinnamic acid analogues in rosmarinic acid to inhibition of snake venom induced hemorrhage

(2011) Hnin Thanda Aung et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cross-cultural comparison of medicinal floras used against snakebites

(2011) Marianne Molander et al.   JOURNAL OF ETHNOPHARMACOLOGY

In silico identification of viper phospholipaseA2 inhibitors: validation by in vitro, in vivo studies

(2011) Amit Nargotra et al.   JOURNAL OF MOLECULAR MODELING

Antiophidic Solanidane Steroidal Alkaloids from Solanum campaniforme

(2011) Maria Conceição M. Torres et al.   JOURNAL OF NATURAL PRODUCTS

Ending the drought: New strategies for improving the flow of affordable, effective antivenoms in Asia and Africa

(2011) David J. Williams et al.   Journal of Proteomics

Antihaemorrhagic potentials ofFagonia creticaagainstNaja naja karachiensis(black Pakistan cobra) venom

(2011) Muhammad Tahir Razi et al.   NATURAL PRODUCT RESEARCH

Anti-snake venom activities of extracts and fractions from callus cultures ofSapindus saponaria

(2011) Marcos L. da Silva et al.   PHARMACEUTICAL BIOLOGY

The belonging of gpMuc, a glycoprotein from Mucuna pruriens seeds, to the Kunitz-type trypsin inhibitor family explains its direct anti-snake venom activity

(2011) Andrea Scirè et al.   PHYTOMEDICINE

New Perspectives on Chinese Herbal Medicine (Zhong-Yao) Research and Development

(2010) Si-Yuan Pan et al.   Evidence-based Complementary and Alternative Medicine

Ethnomedical uses of Zingiberaceous plants of Northeast India

(2010) Tushar et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inhibition of the inflammatory and coagulant action of Bothrops atrox venom by the plant species Marsypianthes chamaedrys

(2010) Alcineide Magalhães et al.   JOURNAL OF ETHNOPHARMACOLOGY

Rosmarinic acid in Argusia argentea inhibits snake venom-induced hemorrhage

(2010) Hnin Thanda Aung et al.   Journal of Natural Medicines

In Vitro Antiophidian Properties of Dipteryx alata Vogel Bark Extracts

(2010) Virgínia Sbrugnera Nazato et al.   MOLECULES

Chemical Constituents of the Bark of Dipteryx alata Vogel, an Active Species against Bothrops jararacussu Venom

(2010) Pilar Puebla et al.   MOLECULES

Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella

(2010) M. H. Toyama et al.   PROTEIN JOURNAL

Structure, function and evolution of three-finger toxins: Mini proteins with multiple targets

(2010) R. Manjunatha Kini et al.   TOXICON

Role of Huperzine a in the Treatment of Alzheimer's Disease

(2009) Alicia R Desilets et al.   ANNALS OF PHARMACOTHERAPY

Inhibition of Snake Venoms and Phospholipases A2by Extracts from Native and Genetically ModifiedEclipta alba: Isolation of Active Coumestans

(2009) Luciana C. Diogo et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The anti-ophidian properties ofAnacardium occidentalebark extract

(2009) Sampath Ushanandini et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Plucking, pillaging and plundering proteomes with combinatorial peptide ligand libraries

(2009) Pier Giorgio Righetti et al.   JOURNAL OF CHROMATOGRAPHY A

The protective effect of Mucuna pruriens seeds against snake venom poisoning

(2009) Nget Hong Tan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Exploring the Venom Proteome of the Western Diamondback Rattlesnake,Crotalus atrox, via Snake Venomics and Combinatorial Peptide Ligand Library Approaches

(2009) Juan J. Calvete et al.   JOURNAL OF PROTEOME RESEARCH

Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming

(2009) José María Gutiérrez et al.   Journal of Proteomics

Exploring the venom proteome of the African puff adder, Bitis arietans, using a combinatorial peptide ligand library approach at different pHs

(2009) Elisa Fasoli et al.   Journal of Proteomics

Amazonian biodiversity: a view of drug development for Leishmaniasis and malaria

(2009) Leonardo de Azevedo Calderon et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Molecular Docking Studies and Anti-enzymatic Activities of Thai Mango Seed Kernel Extract Against Snake Venoms

(2009) Jiraporn Leanpolchareanchai et al.   MOLECULES

Anti-hemorrhagic Activity of Four Brazilian Vegetable Species Against Bothrops jararaca Venom

(2009) Catarine Massucato Nishijima Nishijima et al.   MOLECULES

Neutralization of local and systemic toxicity ofDaboia russeliivenom byMorus albaplant leaf extract

(2009) K. T. Chandrashekara et al.   PHYTOTHERAPY RESEARCH

Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom

(2009) D.O. Toyama et al.   TOXICON

Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: Contributions to understanding snakebite envenomings and their treatment

(2009) Bruno Lomonte et al.   TOXICON

Ability of a synthetic coumestan to antagonize Bothrops snake venom activities

(2009) Paulo A. Melo et al.   TOXICON

Neutralization of Pharmacological and Toxic Activities of Bothrops Snake Venoms by Schizolobium parahyba (Fabaceae) Aqueous Extract and Its Fractions

(2008) Luis Henrique F. Vale et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Anti-Inflammatory Activity of Oleanolic Acid by Inhibition of Secretory Phospholipase A2

(2008) Kattepura Dharmappa et al.   PLANTA MEDICA

Isolation and characterization of ellagic acid derivatives isolated from Casearia sylvestris SW aqueous extract with anti-PLA2 activity

(2008) Saulo L. Da Silva et al.   TOXICON

Isolation of a snake venom phospholipase A2 (PLA2) inhibitor (AIPLAI) from leaves of Azadirachta indica (Neem): Mechanism of PLA2 inhibition by AIPLAI in vitro condition

(2008) Ashis K. Mukherjee et al.   TOXICON

Estimating the Global Burden of Snakebite Can Help To Improve Management

(2008) Jean-Philippe Chippaux   PLOS MEDICINE

Ability of fucoidan to prevent muscle necrosis induced by snake venom myotoxins: Comparison of high- and low-molecular weight fractions

(2007) Karol Azofeifa et al.   TOXICON