Nrf2 deficiency increases oligodendrocyte loss, demyelination, neuroinflammation and axonal damage in an MS animal model

Oxidative Stress Related to Iron Metabolism in Relapsing Remitting Multiple Sclerosis Patients With Low Disability

(2019) Mariacristina Siotto et al.   Frontiers in Neuroscience

Chemical hypoxia-induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2)

(2018) Nico Teske et al.   JOURNAL OF NEUROCHEMISTRY

Effects of vitamin D on axonal damage during de- and remyelination in the cuprizone model

(2018) Agnes E. Nystad et al.   JOURNAL OF NEUROIMMUNOLOGY

Expression Profiles of Metallothionein I/II and Megalin in Cuprizone Model of De- and Remyelination

(2018) Hrvoje Jakovac et al.   NEUROSCIENCE

Effect of Chronic Oxidative Stress on Neuroinflammatory Response Mediated by CD4+T Cells in Neurodegenerative Diseases

(2018) Helena Solleiro-Villavicencio et al.   Frontiers in Cellular Neuroscience

Oxidative stress and neuroinflammation should be both considered in the occurrence of fatigue and depression in multiple sclerosis

(2018) Vesic Katarina et al.   ACTA NEUROLOGICA BELGICA

Nrf2 Signaling in Sodium Azide-Treated Oligodendrocytes Restores Mitochondrial Functions

(2018) Annette Liessem-Schmitz et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Visualization of the Breakdown of the Axonal Transport Machinery: a Comparative Ultrastructural and Immunohistochemical Approach

(2018) Sebastian Rühling et al.   MOLECULAR NEUROBIOLOGY

Cuprizone-induced graded oligodendrocyte vulnerability is regulated by the transcription factor DNA damage-inducible transcript 3

(2018) Felix Fischbach et al.   GLIA

Mitochondrial Impairment in Oligodendroglial Cells Induces Cytokine Expression and Signaling

(2018) Miriam Scheld et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization

(2018) Gerardo G. Piroli et al.   MOLECULAR & CELLULAR PROTEOMICS

Cuprizone-Containing Pellets Are Less Potent to Induce Consistent Demyelination in the Corpus Callosum of C57BL/6 Mice

(2017) Tanja Hochstrasser et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease

(2017) Athanassios Fragoulis et al.   Redox Biology

Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model

(2017) Stefan A. Berghoff et al.   Acta Neuropathologica Communications

Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model

(2016) T. Draheim et al.   GLIA

Neurodegeneration Triggers Peripheral Immune Cell Recruitment into the Forebrain

(2016) M. Scheld et al.   JOURNAL OF NEUROSCIENCE

Regulatory effect of triiodothyronine on brain myelination and astrogliosis after cuprizone-induced demyelination in mice

(2016) Adib Zendedel et al.   METABOLIC BRAIN DISEASE

Nrf2 in health and disease: current and future clinical implications

(2015) O. Al-Sawaf et al.   CLINICAL SCIENCE

Structural basis of Keap1 interactions with Nrf2

(2015) Peter Canning et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview

(2015) Roberto Bomprezzi   Therapeutic Advances in Neurological Disorders

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

(2015) Joe Dan Dunn et al.   Redox Biology

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Mammalian SOD2 is exclusively located in mitochondria and not present in peroxisomes

(2013) Srikanth Karnati et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions

(2012) Tim Clarner et al.   GLIA

Import, Maturation, and Function of SOD1 and Its Copper Chaperone CCS in the Mitochondrial Intermembrane Space

(2010) Hibiki Kawamata et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of Fumaric Acids on Cuprizone Induced Central Nervous System De- and Remyelination in the Mouse

(2010) Darius Moharregh-Khiabani et al.   PLoS One

Oligodendrocytes: biology and pathology

(2009) Monika Bradl et al.   ACTA NEUROPATHOLOGICA

Mitochondrial defects in acute multiple sclerosis lesions

(2008) Don Mahad et al.   BRAIN

Neurodegeneration in multiple sclerosis: The role of oxidative stress and excitotoxicity

(2008) R.E. Gonsette   JOURNAL OF THE NEUROLOGICAL SCIENCES

Kavalactones Protect Neural Cells against Amyloid   Peptide-Induced Neurotoxicity via Extracellular Signal-Regulated Kinase 1/2-Dependent Nuclear Factor Erythroid 2-Related Factor 2 Activation

(2008) C. J. Wruck et al.   MOLECULAR PHARMACOLOGY