Article
Health Care Sciences & Services
Mariacristina Siotto, Marco Germanotta, Massimo Santoro, Raffaella Canali, Simona Pascali, Sabina Insalaco, Valeria Cipollini, Dionysia Papadopoulou, Erika Antonacci, Irene Aprile
Summary: This study analyzed the oxidative stress status in subacute stroke patients undergoing rehabilitation treatments and found that almost all patients had high levels of oxidative stress. Females had lower antioxidant activity and relative antioxidant capacity compared to males. In the male group, higher oxidative stress levels were associated with worse motor performance and disability. Further research is needed to determine if there are persistent sex differences in oxidative stress status in subacute stroke patients after rehabilitation.
Article
Multidisciplinary Sciences
Pattaraporn Thepsuwan, Asmita Bhattacharya, Zhenfeng Song, Stephen Hippleheuser, Shaobin Feng, Xiaoqiong Wei, Nupur K. Das, Mariana Sierra, Juncheng Wei, Deyu Fang, Yu-Ming M. Huang, Kezhong Zhang, Yatrik M. Shah, Shengyi Sun
Summary: The SEL1L-HRD1 protein complex of endoplasmic reticulum-associated degradation (ERAD) in hepatocytes controls systemic iron homeostasis through regulating ceruloplasmin (CP), a ferroxidase involved in iron distribution. The absence of ERAD leads to accumulation of CP in the ER and increased secretion, affecting iron distribution and oxidation status.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Charlotte Roy, Sylvie Avril, Claire Legendre, Benedicte Lelievre, Honorine Vellenriter, Sebastien Boni, Jerome Cayon, Catherine Guillet, Yannick Guilloux, Michel Cherel, Francois Hindre, Emmanuel Garcion
Summary: GB cells depend on iron metabolism and pathways related to it, and iron is related to the sensitivity of GB cells to radiation therapy. The study found that ceruloplasmin (CP) has functional effects on GB cell response to beam radiation, and its overexpression increases the effectiveness of radiation therapy.
Article
Biochemistry & Molecular Biology
D. A. Santiago Gonzalez, V. T. Cheli, S. L. Rosenblum, G. Denaroso, P. M. Paez
Summary: Ceruloplasmin is an essential ferroxidase enzyme for cell iron efflux and plays a crucial role in promoting the maturation of OLs and SCs by regulating iron balance and preventing oxidative stress and neurodegeneration in the central and peripheral nervous systems.
Article
Fisheries
Zhe Wang, Xueshan Li, Kangle Lu, Ling Wang, Xuekun Ma, Kai Song, Chunxiao Zhang
Summary: This study investigated the effects of dietary iron levels on growth performance, iron metabolism, and antioxidant status in spotted seabass. The results showed that meeting the iron requirements of spotted seabass improved growth, feed utilization, and antioxidant capacity.
Article
Cell Biology
Brandon D. Anderson, Timothy Lee, Brent Bell, Ying Song, Joshua L. Dunaief
Summary: In this report, a 39-year-old patient with hereditary hemochromatosis (HH) and high serum iron levels was diagnosed with bull's eye maculopathy, a form of retinal degeneration. The low levels of ferroxidase ceruloplasmin (CP) in the patient and the high iron levels were hypothesized to be the cause of the retinal degeneration. A mouse model combining hepcidin knockout (KO) and Cp KO was used to study the role of CP in retinal degeneration, and it was found that Cp KO increased the severity of retinal degeneration. These findings suggest that CP levels may influence the severity of retinal degeneration, particularly in individuals with high serum iron levels.
DISEASE MODELS & MECHANISMS
(2023)
Article
Biochemistry & Molecular Biology
Lijing Niu, Yi Zhou, Li Lu, Aixia Su, Xiaoqiang Guo
Summary: Iron accumulation is an important cause of brain diseases. Ceruloplasmin (Cp) plays a key role in iron homeostasis and its deficiency leads to iron accumulation in various tissues and organs. Although there is no obvious change in iron content in brain tissues, Cp deficiency affects the expression of iron metabolism-related proteins in the midbrain. Furthermore, Cp deficiency impairs the behavioral ability of mice.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Physiology
Yi Zhang, Jialong Wu, Lai Jiang, Chenkang Lu, Zhengwei Huang, Bin Liu
Summary: Fluorine induces oxidative stress leading to cellular damage; depletion of GSH and increased oxidized GSH in high fluoride environments; fluoride-induced oxidative stress and ferroptosis are related due to iron metabolism disorders.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Agriculture, Dairy & Animal Science
David Soldado, Rui J. B. Bessa, Eliana Jeronimo
Summary: Condensed tannins (CTs) are secondary plant metabolites known for their antinutritional properties but also for their beneficial attributes for animal health and food quality, including antioxidant activity. Utilization of CT-rich sources in ruminant feeding can improve the animals' antioxidant status and oxidative stability of their products. However, the mechanism underlying the antioxidant activity of CT sources in ruminants is still not fully understood.
Article
Clinical Neurology
Till S. Zimmer, Bastian David, Diede W. M. Broekaart, Martin Schidlowski, Gabriele Ruffolo, Anatoly Korotkov, Nicole N. van der Wel, Peter C. van Rijen, Angelika Muhlebner, Wim van Hecke, Johannes C. Baayen, Sander Idema, Liesbeth Francois, Jonathan van Eyll, Stefanie Dedeurwaerdere, Helmut W. Kessels, Rainer Surges, Theodor Rueber, Jan A. Gorter, James D. Mills, Erwin A. van Vliet, Eleonora Aronica
Summary: Neuronal dysfunction caused by iron accumulation and reactive oxygen species may play a significant role in the epileptogenic process, while alterations in iron metabolism in the epileptic brain have not been extensively studied. Through clinical and animal experiments, as well as in vitro cell culture, the study revealed the mechanisms of iron in epilepsy pathology and antioxidant metabolism.
ACTA NEUROPATHOLOGICA
(2021)
Article
Biochemistry & Molecular Biology
Izabela Kokot, Agnieszka Piwowar, Marcin Jedryka, Ewa Maria Kratz
Summary: The study found that serum concentrations of FRAP, telomerase and AOPP were significantly higher in patients with endometriosis and other gynecological disorders, indicating their potential as promising diagnostic markers for endometriosis.
Article
Food Science & Technology
Bibi Hajira, Imran Khan
Summary: This study found that bread incorporated with whole-grain red sorghum and barley flours can enhance plasma total polyphenols and antioxidant status, thereby modulating biomarkers of cardio-metabolic health.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2022)
Article
Medicine, General & Internal
Shiva Ganjali, Reihaneh Keshavarz, Susan Hosseini, Atena Mansouri, Massimo R. Mannarino, Matteo Pirro, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: This study revealed significant differences in oxidant/antioxidant markers between FH patients and healthy individuals, as well as between HoFH and HeFH patients. These differences may be strongly associated with plasma LDL-C levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Tahir Karasahin, Hasan Alkan, Fatma Satilmis, Sukru Dursun, Caner Ozturk, Gaye Bulut, Nese Hayat Aksoy, Mustafa Agah Tekindal, Tamer Caglayan, Omer Faruk Yesilkaya, Huseyin Erdem
Summary: This study found that serum total antioxidant status (TAS) was positively correlated with the counts of transferable embryo and embryo quality, while total oxidant status (TOS) and oxidative stress index (OSI) were negatively correlated with the counts of transferable embryo and Code I embryo, and positively correlated with unfertilized oocyte counts.
Article
Biochemistry & Molecular Biology
Guglielmo Duranti, Mariateresa Maldini, Domenico Crognale, Katy Horner, Ivan Dimauro, Stefania Sabatini, Roberta Ceci
Summary: Moringa oleifera leaf extract (MOLE) has been shown to improve oxidative metabolism in skeletal muscle cells through the SIRT1-PPAR alpha pathway, potentially benefiting muscle health through modulation of redox status.
Article
Gastroenterology & Hepatology
Giammauro Berardi, Francesca Ratti, Carlo Sposito, Martina Nebbia, Daniel M. D'Souza, Franco Pascual, Epameinondas Dogeas, Samer Tohme, Francesco E. D'Amico, Remo Alessandris, Ilaria Simonelli, Celeste Del Basso, Nadia Russolillo, Amika Moro, Guido Fiorentini, Matteo Serenari, Fernando Rotellar, Giuseppe Zimmitti, Simone Famularo, Tommy Ivanics, Daniel Hoffman, Edwin Onkendi, Yasmin Essaji, Santiago Lopez Ben, Celia Caula, Gianluca Rompianesi, Asmita Chopra, Mohammed Abu Hilal, Guido Torzilli, Gonzalo Sapisochin, Carlos Corvera, Adnan Alseidi, Scott Helton, Roberto I. Troisi, Kerri Simo, Claudius Conrad, Matteo Cescon, Sean Cleary, Choon H. D. Kwon, Alessandro Ferrero, Giuseppe M. Ettorre, Umberto Cillo, David Geller, Daniel Cherqui, Pablo E. Serrano, Cristina Ferrone, Vincenzo Mazzaferro, Luca Aldrighetti, T. Peter Kingham
Summary: A predictive model for postoperative major morbidity after liver resection in patients with metabolic syndrome and HCC has been developed and validated, identifying obesity, diabetes, ischemic heart disease, and other factors as risk factors for major complications.
Article
Radiology, Nuclear Medicine & Medical Imaging
Carlo C. Quattrocchi, Marco Parillo, Federica Spani, Doriana Landi, Gaia Cola, Caterina Dianzani, Eleonora Perrella, Girolama A. Marfia, Carlo A. Mallio
Summary: This study aimed to assess the presence of detectable changes in skin thickness on brain MRI scans in patients with MS, a history of GBCAs administrations, and evidence of gadolinium deposition in the brain. Qualitative and quantitative assessment of skin thickness revealed significant differences between patients with and without evidence of gadolinium deposition.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Clinical Neurology
Francesca Proietti, Doriana Landi, Marta Ponzano, Gaia Cola, Giovanni Di Mauro, Giorgia Mataluni, Carolina Gabri Nicoletti, Giuseppe Curcio, Girolama Alessandra Marfia
Summary: The aim of this study was to explore the COVID-19 vaccine hesitancy rate in people with multiple sclerosis (pwMS). The results showed that 90% of the respondents were willing to get vaccinated, while only 1.4% were sure to refuse the vaccination. Education level, opinions on safety and efficacy of vaccines, and emotional status were found to be associated with the propensity of getting the COVID-19 vaccination.
NEUROLOGICAL SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Loreta A. Kondili, Maria Giovanna Quaranta, Luisa Cavalletto, Vincenza Calvaruso, Luigina Ferrigno, Roberta D'Ambrosio, Ilaria Simonelli, Giuseppina Brancaccio, Giovanni Raimondo, Maurizia R. Brunetto, Anna Linda Zignego, Carmine Coppola, Andrea Iannone, Elisa Biliotti, Gabriella Verucchi, Marco Massari, Anna Licata, Francesco Barbaro, Marcello Persico, Francesco Paolo Russo, Filomena Morisco, Maurizio Pompili, Mauro Vigano, Massimo Puoti, Teresa Santantonio, Erica Villa, Antonio Craxi, Liliana Chemello
Summary: This study evaluated the long-term risk of hepatocellular carcinoma (HCC) in patients with cirrhosis after hepatitis C virus (HCV) eradication. Age, genotype 3, diabetes, platelets and albumin levels were identified as predictors of HCC risk. Furthermore, post-treatment platelet and albumin levels were found to independently predict HCC occurrence.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Obstetrics & Gynecology
Luigi Carbone, Raffaella Di Girolamo, Alessandro Conforti, Giuseppe Gabriele Iorio, Vittorio Simeon, Doriana Landi, Girolama Alessandra Marfia, Roberta Lanzillo, Carlo Alviggi
Summary: Recent evidence suggests that women with multiple sclerosis (MS) have lower anti-Mullerian hormone (AMH) levels, but the difference in serum AMH levels between MS patients and healthy controls is not significant. However, there are significant differences in antral follicle count (AFC), estradiol, and luteinizing hormone (LH) levels between the two groups.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Biochemistry & Molecular Biology
Rosanna Squitti, Claudio Catalli, Laura Gigante, Massimo Marianetti, Mattia Rosari, Stefania Mariani, Serena Bucossi, Gioia Mastromoro, Mariacarla Ventriglia, Ilaria Simonelli, Vincenzo Tondolo, Parminder Singh, Ashok Kumar, Amit Pal, Mauro Rongioletti
Summary: Alzheimer's disease (AD), a type of dementia, has an unclear cause. A meta-analysis confirmed the involvement of copper (Cu) in AD, showing decreased Cu levels in AD brain specimens and increased Cu levels in serum/plasma samples. Non-bound ceruloplasmin Cu (non-Cp Cu) was proposed as a biomarker for a Cu subtype of AD (CuAD subtype). Evaluating non-Cp Cu reliability in classifying AD subtypes based on cognitive profiles confirmed its significance and identified potential therapeutic options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Virology
Isha Rani, Prakasini Satapathy, Anmol Goyal, Muhammad Aaqib Shamim, Amit Pal, Rosanna Squitti, Kalyan Goswami, Keerti Bhusan Pradhan, Sarvesh Rustagi, Alaa Hamza Hermis, Joshuan J. Barboza, Alfonso J. Rodriguez-Morales, Ranjit Sah, Bijaya K. Padhi
Summary: This study aimed to estimate cutaneous viral loads among monkeypox patients globally. The results showed that the viral loads in skin lesions were high, indicating a higher risk of infection. This finding is important for guiding relevant health policies.
Editorial Material
Nutrition & Dietetics
Mariacristina Siotto, Irene Aprile
Article
Chemistry, Multidisciplinary
Alessandro Guerrini, Mariacristina Siotto, Marco Germanotta, Mirko Schirru, Arianna Pavan, Valeria Cipollini, Sabina Insalaco, Irene Aprile
Summary: In this longitudinal prospective study, body composition parameters, particularly BCM, were investigated in a cohort of subacute post-stroke patients undergoing rehabilitation. The study found that patients' body composition did not change after the rehabilitation program and that higher values of BCM were associated with better recovery and ADL performance. Assessing BCM at admission may be useful in evaluating the nutritional status and predicting recovery in post-stroke patients.
APPLIED SCIENCES-BASEL
(2023)
Article
Neurosciences
Pasquale Rinaldi, Arianna Bello, Ilaria Simonelli, Maria Cristina Caselli
Summary: Specific Learning Disorder (SLD) is a complex disorder with a strong genetic component, characterized by varying manifestations and considerable differences among children. Difficulties in language acquisition and Developmental Language Disorders (DLDs) are frequently associated with SLD, suggesting continuity between the two disorders. This study aimed to provide evidence on predictors of SLD, focusing on the continuity of DLD, linguistic and communicative abilities, and biological and environmental factors. Results showed a 7.01% prevalence of SLD, with diagnosis being significantly predicted by previous DLD diagnosis, male gender, and familial risk.
Article
Biochemistry & Molecular Biology
Miguel Tabanez, Ilma R. Santos, Juliane M. Ikebara, Mariana L. M. Camargo, Bianca A. Dos Santos, Bruna M. Freire, Bruno L. Batista, Silvia H. Takada, Rosanna Squitti, Alexandre H. Kihara, Giselle Cerchiaro
Summary: As people age, they become more susceptible to neurodegenerative illnesses such as Alzheimer's disease. This study found that the antioxidant hydroxytyrosol can regulate metal levels and improve learning performance in a rat model of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Cartesio D'Agostini, Jacopo M. Legramante, Marilena Minieri, Vito N. Di Lecce, Maria Stella Lia, Massimo Maurici, Ilaria Simonelli, Marco Ciotti, Carla Paganelli, Alessandro Terrinoni, Alfredo Giovannelli, Massimo Pieri, Mariacarla Gallu, Vito Dell'Olio, Carla Prezioso, Dolores Limongi, Sergio Bernardini, Antonio Orlacchio, Aw Tar-Choon
Summary: The study aimed to assess the association between CT scan results and MR-proADM levels in order to improve the prediction of in-hospital mortality of COVID-19 patients at the triage. The key role of CT score and MR-proADM levels in determining the correct clinical setting for these patients was also evaluated. The results showed that using CT score in combination with MR-proADM levels was particularly effective in risk stratification and decision-making in the emergency department, optimizing hospital resources.
Article
Immunology
Martina Severa, Fabiana Rizzo, Alessandro Sinigaglia, Daniela Ricci, Marilena Paola Etna, Gaia Cola, Doriana Landi, Maria Chiara Buscarinu, Catia Valdarchi, Giovanni Ristori, Silvia Riccetti, Chiara Piubelli, Pierangela Palmerini, Antonio Rosato, Federico Gobbi, Stefano Balducci, Girolama Alessandra Marfia, Marco Salvetti, Luisa Barzon, Eliana Marina Coccia
Summary: This study aimed to investigate the impact of mRNA vaccines on immune responses in immunocompetent individuals and people with multiple sclerosis (pwMS), and to explore the correlation between vaccine-induced immune responses and protective humoral responses. The study found that the early immune response module induced by mRNA vaccines was strongly correlated with the magnitude of immune responses, and this module was affected by certain treatment drugs. The results suggest that vaccine-induced early immune regulation may be mediated by interferon signaling and may indicate vaccine-induced protective immunity.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Vincenzo Parisi, Lucilla Barbano, Giulio Antonelli, Carolina Gabri Nicoletti, Doriana Landi, Giorgia Mataluni, Antonio Di Renzo, Fabio Buttari, Girolama Alessandra Marfia, Diego Centonze, Lucia Ziccardi
Summary: This study investigated the potential correlation between morphological and functional parameters of retinal ganglion cells (RGCs) in the macula in eyes with multiple sclerosis and a history of optic neuritis. The results showed a topographical correlation between the structural and functional impairment of macular RGCs in eyes with multiple sclerosis and optic neuritis.
JOURNAL OF CLINICAL MEDICINE
(2023)