Automated computerized image analysis for the user-independent evaluation of disease severity in preclinical models of NAFLD/NASH

Non-Invasive Assessment of Liver Disease in Patients with NAFLD

(2019) Laurent Castera et al.   GASTROENTEROLOGY

Macrophage p38α promotes nutritional steatohepatitis through M1 polarization

(2019) Xiang Zhang et al.   JOURNAL OF HEPATOLOGY

Hepatic sonic hedgehog protein expression measured by computer assisted morphometry significantly correlates with features of non-alcoholic steatohepatitis

(2019) Michael Estep et al.   BMC GASTROENTEROLOGY

Therapeutic Application of Micellar Solubilized Xanthohumol in a Western-Type Diet-Induced Mouse Model of Obesity, Diabetes and Non-Alcoholic Fatty Liver Disease

(2019) Mahli et al.   Cells

Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease

(2018) Juan Pablo Arab et al.   Annual Review of Pathology-Mechanisms of Disease

Radiologic Imaging in Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

(2018) Yonah B. Esterson et al.   Clinics in Liver Disease

A critical review of endpoints for non-cirrhotic NASH therapeutic trials

(2018) Vlad Ratziu   JOURNAL OF HEPATOLOGY

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease

(2018) Thomas Jensen et al.   JOURNAL OF HEPATOLOGY

Matrix metalloproteinases and liver fibrosis (translational aspects)

(2018) Elke Roeb   MATRIX BIOLOGY

Automated assessment of steatosis in murine fatty liver

(2018) Deepak Sethunath et al.   PLoS One

Focused scores enable reliable discrimination of small differences in steatosis

(2018) André Homeyer et al.   Diagnostic Pathology

Activation of brown adipose tissue enhances the efficacy of caloric restriction for treatment of nonalcoholic steatohepatitis

(2018) Laurence Poekes et al.   LABORATORY INVESTIGATION

Dietary Lipids Differentially Shape NASH Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages

(2018) Brett McGettigan et al.   HEPATOLOGY

Mouse models of nonalcoholic steatohepatitis Towards optimization of their relevance to human NASH

(2018) Geoff Farrell et al.   HEPATOLOGY

The role of 3D-MRE in the diagnosis of NASH in obese patients undergoing bariatric surgery

(2018) Alina M. Allen et al.   HEPATOLOGY

Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling

(2018) Jessie Qiaoyi Liang et al.   Nature Communications

Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis

(2017) Parambir S. Dulai et al.   HEPATOLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Molecular MR Imaging of Myeloperoxidase Distinguishes Steatosis from Steatohepatitis in Nonalcoholic Fatty Liver Disease

(2017) Benjamin Pulli et al.   RADIOLOGY

Magnetic resonance imaging and transient elastography in the management of Nonalcoholic Fatty Liver Disease (NAFLD)

(2017) Ma Ai Thanda Han et al.   Expert Review of Clinical Pharmacology

Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD)

(2016) Salamah Mohammad Alwahsh et al.   ARCHIVES OF TOXICOLOGY

Quantification of liver fat: A comprehensive review

(2016) Evgin Goceri et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Zonated quantification of steatosis in an entire mouse liver

(2016) Lars Ole Schwen et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues From Patients

(2016) Andreas Teufel et al.   GASTROENTEROLOGY

Obeticholic acid improves adipose morphometry and inflammation and reduces steatosis in dietary but not metabolic obesity in mice

(2016) Fahrettin Haczeyni et al.   Obesity

Fully-automated, high-throughput micro-computed tomography analysis of body composition enables therapeutic efficacy monitoring in preclinical models

(2015) S K Wyatt et al.   INTERNATIONAL JOURNAL OF OBESITY

Hepatic fibrosis: Concept to treatment

(2015) Christian Trautwein et al.   JOURNAL OF HEPATOLOGY

Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice

(2015) Fahrettin Haczeyni et al.   Obesity

Dynamics of Allograft Fibrosis in Pediatric Liver Transplantation

(2014) C. Venturi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

Endoplasmic reticulum stress does not contribute to steatohepatitis in obese and insulin-resistant high-fat-diet-fedfoz/fozmice

(2014) Vanessa Legry et al.   CLINICAL SCIENCE

Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease

(2014) Pierre Bedossa et al.   HEPATOLOGY

Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH

(2014) George N. Ioannou et al.   JOURNAL OF LIPID RESEARCH

Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver

(2014) Salamah Mohammad Alwahsh   WORLD JOURNAL OF GASTROENTEROLOGY

Limited Correlation Between Conventional Pathologist and Automatic Computer-Assisted Quantification of Hepatic Steatosis due to Difference Between Event-Based and Surface-Based Analysis

(2014) Meihong Deng et al.   IEEE Journal of Biomedical and Health Informatics

An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis

(2013) Masahiko Matsumoto et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Strain dependence of diet-induced NASH and liver fibrosis in obese mice is linked to diabetes and inflammatory phenotype

(2013) Geoffrey C. Farrell et al.   LIVER INTERNATIONAL

Automated image analysis method for detecting and quantifying macrovesicular steatosis in hematoxylin and eosin-stained histology images of human livers

(2013) Nir I. Nativ et al.   LIVER TRANSPLANTATION

Early detection of liver steatosis by magnetic resonance imaging in rats infused with glucose and Intralipid solutions and correlation to insulin levels

(2013) Gaspard d'Assignies et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Dietary modification dampens liver inflammation and fibrosis in obesity-related fatty liver disease

(2013) Claire Z. Larter et al.   Obesity

Hepatic Crown-Like Structure: A Unique Histological Feature in Non-Alcoholic Steatohepatitis in Mice and Humans

(2013) Michiko Itoh et al.   PLoS One

Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis

(2012) Christopher Savard et al.   HEPATOLOGY

Non-Invasive Quantification of White and Brown Adipose Tissues and Liver Fat Content by Computed Tomography in Mice

(2012) Marko Lubura et al.   PLoS One

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease

(2011) Cynthia D. Guy et al.   HUMAN PATHOLOGY

Effects of interventions on intra- and interobserver agreement on interpretation of nonalcoholic fatty liver disease histology

(2010) Samer Gawrieh et al.   Annals of Diagnostic Pathology

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

(2010) Kouichi Miura et al.   GASTROENTEROLOGY

Assessment of Hepatic Steatosis by Expert Pathologists

(2009) Ashraf Mohammad El-Badry et al.   ANNALS OF SURGERY

c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice

(2009) Yuzo Kodama et al.   GASTROENTEROLOGY

Assessment of hepatic steatosis: comparison of quantitative and semiquantitative methods in 108 liver biopsies

(2009) Bruno Turlin et al.   LIVER INTERNATIONAL

Ballooned hepatocytes in steatohepatitis: The value of keratin immunohistochemistry for diagnosis

(2008) Carolin Lackner et al.   JOURNAL OF HEPATOLOGY