Review
Pharmacology & Pharmacy
Honglin Zhou, Cheng Ma, Cheng Wang, Lihong Gong, Yafang Zhang, Yunxia Li
Summary: Non-alcoholic fatty liver disease (NAFLD) is gradually becoming one of the most common chronic liver diseases in the world due to the improvement of living standards and changes in eating habits. Traditional Chinese medicines (TCM) have attracted attention for their multi-target and multi-channel mechanisms in treating NAFLD, showing potential through regulating various pathways for ameliorating the disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Qi Xie, Shuqing Gao, Min Lei, Zengning Li
Summary: This study established a NAFLD model using HFD-fed rats and FFA-stimulated THP-1 cells to examine the role of hesperidin in ERS-induced inflammation in NAFLD pathogenesis. The results showed that hesperidin reduced hepatic steatosis and inflammatory response, as well as the expression of ERS-related biomarkers.
Article
Gastroenterology & Hepatology
Caizhi Liu, Bing Zhou, Meiyao Meng, Wenjun Zhao, Dongmei Wang, Youwen Yuan, Ying Zheng, Jin Qiu, Yu Li, Guoqiang Li, Xuelian Xiong, Hua Bian, Huijie Zhang, Hua Wang, Xinran Ma, Cheng Hu, Lingyan Xu, Yan Lu
Summary: The study identified FOXA3 as a key bridging molecule connecting ER stress and NAFLD progression, with its deficiency alleviating fatty liver. Increased levels of FOXA3 were found in the livers of obese mice and patients with NAFLD, suggesting FOXA3 as a potential therapeutic target for fatty liver disease.
JOURNAL OF HEPATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jing Zhang, Quansheng Feng
Summary: Astragalus polysaccharides (APS), a chemical molecule derived from Astragalus membranaceus, have shown potential therapeutic effects on nonalcoholic fatty liver disease (NAFLD). APS may help slow the progression of NAFLD through multiple molecular pathways. However, further research and clinical evidence are still needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Man Na, Xingbiao Yang, Yongkun Deng, Zhaoheng Yin, Mingwei Li
Summary: The endoplasmic reticulum (ER) plays a crucial role in protein synthesis and modification. Alcohol metabolites can induce ER stress, worsening the progression of alcoholic liver disease. Understanding the contribution of ER stress to the pathogenesis of liver diseases may lead to innovative therapeutic interventions.
Article
Agriculture, Dairy & Animal Science
Zhiyuan Fang, Wenwen Gao, Qianming Jiang, Juan J. Loor, Chenchen Zhao, Xiliang Du, Min Zhang, Yuxiang Song, Zhe Wang, Guowen Liu, Xinwei Li, Lin Lei
Summary: Endoplasmic reticulum (ER) stress induced by nonesterified fatty acids (NEFA) contributes to hepatic insulin resistance in dairy cows. This study unraveled the mechanisms involving the ER stress sensors IRE1 alpha and PERK in the development of NEFA-induced insulin resistance and demonstrated that inhibition of these signaling pathways could alleviate insulin resistance.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Dan Zhang, Shanzhuang Niu, Yicheng Ma, Hang Chen, Yu Wen, Mingke Li, Bo Zhou, Yi Deng, Chunjing Shi, Guangyu Pu, Meng Yang, Xianmei Wang, Chenggang Zou, Yuanli Chen, Lanqing Ma
Summary: This study found that fenofibrate can alleviate ER stress and improve the pathology of NAFLD by regulating the expression of let-7 miRNA and SERCA2b. This provides new insights into the specific mechanism of fenofibrate in treating NAFLD and improving lipid metabolism disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Poliana C. Marinello, Paola S. Cella, Mayra T. J. Testa, Phillipe B. Guirro, Walison Augusto da Silva Brito, Camila S. Padilha, Alessandra L. Cecchini, Robin P. da Silva, Jose Alberto R. Duarte, Rafael Deminice
Summary: This study investigated the effects of creatine supplementation on the pathogenesis of non-alcoholic fatty liver disease and alcoholic liver disease. The results showed that creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease but exacerbated ethanol-induced alcoholic liver disease. The exacerbating effects may be related to oxidative stress and inflammation-mediated upregulation of ethanol metabolism.
Article
Biochemistry & Molecular Biology
Vagner Ramon R. Silva, Angela Molinaro, Andrea Usseglio Gaudi, Emanuel Fryk, Claudia Sardi, Maria Hammarlund, Filip Mjornstedt, Maria E. Johansson, Barbara Becattini, Per-Anders Jansson, Giovanni Solinas
Summary: This study investigates the role of IKK beta signaling in obesity. The results show that the deletion of IKK beta in the liver and leukocytes is not tolerated in obese mice exposed to TLR3 agonists. However, selective hepatic IKK beta ablation improves fatty liver and insulin sensitivity.
Article
Pharmacology & Pharmacy
Peng Yu, Zhen Qian, Hongmei Yang, Tianyang Xu, Yulin Dai, Laihui Song, Jinling Liang, Yuying Shi, Zhiguo Zhang, Lijing Li
Summary: Icariin (ICA) can attenuate non-alcoholic fatty liver disease (NAFLD) by reducing liver lipid deposition and improving insulin sensitivity, glucose tolerance, etc. The main metabolite of ICA, icaritin (ICT), inhibits hepatic lipid accumulation and lipogenesis by reducing endoplasmic reticulum (ER) stress.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Yi Chen, Xueyang Chen, Qiang Chen, Chaohui Yu
Summary: The prevalence of NAFLD is higher in PA patients compared to non-PA patients, with hypokalemic PA patients having a worse metabolic status. Although NAFLD is more common in PA patients, the patterns of obesity, dyslipidemia, and insulin resistance are similar. This study provides new insights for further investigations into metabolic imbalance in patients with aldosteronism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yu Luo, Qiangqiang Jiao, Yuping Chen
Summary: ER stress is widely present in NAFLD and plays a significant role in its pathophysiology. Understanding the mechanisms and molecular targets associated with ER stress can lead to the discovery of new biomarkers and therapeutic strategies for NAFLD.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Chemistry, Multidisciplinary
Xue Li, Mingming Zhen, Chen Zhou, Meilan Yu, Lei Liu, Chunying Shu, Chunru Wang
Summary: This study investigates the use of hydroxylated [70] fullerene nanoparticles (HFNPs) as antioxidants to reverse insulin resistance in diabetes. The study shows that HFNPs can alleviate insulin resistance by regulating oxidative stress and endoplasmic reticulum stress, resulting in improved glucose uptake and reduced blood glucose levels. Furthermore, HFNPs inhibit the activation of phosphorylated c-Jun N-terminal kinase (JNK), reactivating the insulin receptor substrate (IRS) signaling pathway and inhibiting gluconeogenesis. Importantly, HFNPs exhibit no severe toxicity to main tissues. This research contributes to the understanding of the role of antioxidants in regulating insulin resistance and provides new perspectives for the treatment of insulin resistance-related diseases.
Article
Cell Biology
Xiangyu Wang, Huaping Zhang, Pengfu Zhang, Shulan Hao, Xi Yang, Xin Zhou
Summary: The study found that LPS levels were significantly associated with inflammatory factors, as well as the expression of ER stress-related genes and proteins in patients with MS.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Chemistry, Medicinal
Ali Ahmadi, A. Wallace Hayes, Gholamreza Karimi
Summary: The endoplasmic reticulum (ER) performs essential functions in cellular biology, such as synthesizing lipids and controlling protein folding. Inflammation and oxidative stress can lead to protein misfolding in the ER. Resveratrol (RSV) has various bioactive properties and is known for its potential beneficial effects on health.
PHYTOTHERAPY RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Elisabeth M. G. de Vries, Manon de Krijger, Martti Faerkkilae, Johanna Arola, Peter Schirmacher, Daniel Gotthardt, Benjamin Goeppert, Palak J. Trivedi, Gideon M. Hirschfield, Henriette Ytting, Ben Vainer, Henk R. van Buuren, Katharina Biermann, Maren H. Harms, Olivier Chazouilleres, Dominique Wendum, Astrid D. Kemgang, Roger W. Chapman, Lai Mun Wang, Kate D. Williamson, Annette S. H. Gouw, Valerie Paradis, Christine Sempoux, Ulrich Beuers, Stefan G. Huebscher, Joanne Verheij, Cyriel Y. Ponsioen
Article
Cell Biology
Joan Saldarriaga, Bettina Bisig, Gabrielle Couchy, Claire Castain, Jessica Zucman-Rossi, Charles Balabaud, Christine Sempoux, Paulette Bioulac-Sage
Article
Pathology
Christine Sempoux, Bettina Bisig, Gabrielle Couchy, Charles Balabaud, Jessica Zucman-Rossi, Paulette Bioulac-Sage
Article
Gastroenterology & Hepatology
Daniela Lenggenhager, Jerome Gouttenoire, Mohsen Malehmir, Marion Bawohl, Hanna Honcharova-Biletska, Susanne Kreutzer, David Semela, Jorg Neuweiler, Sandra Hurlimann, Patrick Aepli, Montserrat Fraga, Roland Sahli, Luigi Terracciano, Laura Rubbia-Brandt, Beat Mullhaupt, Christine Sempoux, Darius Moradpour, Achim Weber
JOURNAL OF HEPATOLOGY
(2017)
Article
Oncology
Styliani Mantziari, Pierre Allemann, Michael Winiker, Christine Sempoux, Nicolas Demartines, Markus Schafer
JOURNAL OF SURGICAL ONCOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Denis A. Mogilenko, Joel T. Haas, Laurent L'homme, Sebastien Fleury, Sandrine Quemener, Matthieu Levavasseur, Coralie Becquart, Julien Wartelle, Alexandra Bogomolova, Laurent Pineau, Olivier Molendi-Coste, Steve Lancel, Helene Dehondt, Celine Gheeraert, Aurelie Melchior, Cedric Dewas, Artemii Nikitin, Samuel Pic, Nabil Rabhi, Jean-Sebastien Annicotte, Seiichi Oyadomari, Talia Velasco-Hernandez, Jorg Cammenga, Marc Foretz, Benoit Viollet, Milica Vukovic, Arnaud Villacreces, Kamil Kranc, Peter Carmeliet, Guillemette Marot, Alexis Boulter, Simon Tavernier, Luciana Berod, Maria P. Longhi, Christophe Paget, Sophie Janssens, Delphine Staumont-Salle, Ezra Aksoy, Bart Staels, David Dombrowicz
Correction
Biochemistry & Molecular Biology
Denis A. Mogilenko, Joel T. Haas, Laurent L'homme, Sebastien Fleury, Sandrine Quemener, Matthieu Levavasseur, Coralie Becquart, Julien Wartelle, Alexandra Bogomolova, Laurent Pineau, Olivier Molendi-Coste, Steve Lancel, Helene Dehondt, Celine Gheeraert, Aurelie Melchior, Cedric Dewas, Artemii Nikitin, Samuel Pic, Nabil Rabhi, Jean-Sebastien Annicotte, Seiichi Oyadomari, Talia Velasco-Hernandez, Jorg Cammenga, Marc Foretz, Benoit Viollet, Milica Vukovic, Arnaud Villacreces, Kamil Kranc, Peter Carmeliet, Guillemette Marot, Alexis Boulter, Simon Tavernier, Luciana Berod, Maria P. Longhi, Christophe Paget, Sophie Janssens, Delphine Staumont-Salle, Ezra Aksoy, Bart Staels, David Dombrowicz
Article
Biology
Asma Ayari, Manuel Rosa-Calatrava, Steve Lancel, Johanna Barthelemy, Andres Pizzorno, Alicia Mayeuf-Louchart, Morgane Baron, David Hot, Lucie Deruyter, Daphnee Soulard, Thomas Julien, Christelle Faveeuw, Olivier Molendi-Coste, David Dombrowicz, Laura Sedano, Valentin Sencio, Ronan Le Goffic, Francois Trottein, Isabelle Wolowczuk
COMMUNICATIONS BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Laurent L'homme, Benan Pelin Sermikli, Olivier Molendi-Coste, Sebastien Fleury, Sandrine Quemener, Mathilde Le Maitre, Marie-Laure Joseph, Laurent Pineau, Christian Duhem, Barbara Gross, Emmanuelle Vallez, Anne Tailleux, Bart Staels, David Dombrowicz
SCIENTIFIC REPORTS
(2020)
Article
Biology
Erwan Goy, Maxime Tomezak, Caterina Facchin, Nathalie Martin, Emmanuel Bouchaert, Jerome Benoit, Clementine de Schutter, Joe Nassour, Laure Saas, Claire Drullion, Priscille M. Brodin, Alexandre Vandeputte, Olivier Molendi-Coste, Laurent Pineau, Gautier Goormachtigh, Olivier Pluquet, Albin Pourtier, Fabrizio Cleri, Eric Lartigau, Nicolas Penel, Corinne Abbadie
Summary: Induction of second primary cancers is a rare but severe complication of curative-intent radiation therapy. Research shows that normal human or mouse dermal fibroblasts exposed to out-of-field radiation dose at the margin of the target volume do not die, but enter a long-lived senescent state, leading to the accumulation of unrepaired DNA single-strand breaks. Some of these senescent cells eventually escape cell cycle arrest and give rise to daughter cells with mutations and invasive properties. This discovery highlights the role of single-strand break-induced senescence as the mechanism of second primary cancer initiation, with potential implications for prevention.
Article
Biochemistry & Molecular Biology
Nicolas Lanthier, Valerie Lebrun, Olivier Molendi-Coste, Nico van Rooijen, Isabelle A. Leclercq
Summary: This study found that a high-fat diet leads to overexpression of fetuin-A in the liver, which occurs concurrently with hepatic steatosis and insulin resistance. Targeting liver macrophages can reduce the expression of fetuin-A and improve insulin sensitivity.
Meeting Abstract
Gastroenterology & Hepatology
Simon Peschard, Margaux Nawrot, Laurent Pineau, Joel Haas, Olivier Molendi-Coste, David Dombrowicz, Bart Staels, Sophie Lestavel
JOURNAL OF HEPATOLOGY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Margaux Nawrot, Simon Peschard, Emmanuelle Vallez, Emilie Dorchies, Olivier Molendi-Coste, Laurent Pineau, Anne Tailleux, David Dombrowicz, Bart Staels, Sophie Lestavel
JOURNAL OF HEPATOLOGY
(2021)
Correction
Endocrinology & Metabolism
Joel T. Haas, Luisa Vonghia, Denis A. Mogilenko, An Verrijken, Olivier Molendi-Coste, Sebastien Fleury, Audrey Deprince, Artemii Nikitin, Eloise Woitrain, Lucie Ducrocq-Geoffroy, Samuel Pic, Bruno Derudas, Helene Dehondt, Celine Gheeraert, Luc Van Gaal, Ann Driessen, Philippe Lefebvre, Bart Staels, Sven Francque, David Dombrowicz
Article
Endocrinology & Metabolism
Joel T. Haas, Luisa Vonghia, Denis A. Mogilenko, An Verrijken, Olivier Molendi-Coste, Sebastien Fleury, Audrey Deprince, Artemii Nikitin, Eloise Woitrain, Lucie Ducrocq-Geoffroy, Samuel Pic, Bruno Derudas, Helene Dehondt, Celine Gheeraert, Luc Van Gaal, Ann Driessen, Philippe Lefebvre, Bart Staels, Sven Francque, David Dombrowicz