Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia
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Title
Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia
Authors
Keywords
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Journal
JOURNAL OF VIROLOGY
Volume 93, Issue 20, Pages -
Publisher
American Society for Microbiology
Online
2019-07-30
DOI
10.1128/jvi.00814-19
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Note: Only part of the references are listed.- Humanized mouse models of immunological diseases and precision medicine
- (2019) Leonard D. Shultz et al. MAMMALIAN GENOME
- Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes
- (2019) Sean P. O’Brien et al. PLoS Pathogens
- Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19)
- (2018) Dan H Barouch et al. LANCET
- Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity
- (2018) Sai Majji et al. MALARIA JOURNAL
- Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model
- (2018) Kimberly Schmitt et al. VIROLOGY
- Humanized NOG mice as a model for tuberculosis vaccine-induced immunity: a comparative analysis with the mouse and guinea pig models of tuberculosis
- (2017) Ajay Grover et al. IMMUNOLOGY
- High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end-stage liver disease
- (2017) Ditte L. Hedegaard et al. JOURNAL OF HEPATOLOGY
- Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine
- (2017) Yushi Yao et al. JOURNAL OF INFECTIOUS DISEASES
- Novel Role for Interleukin-17 in Enhancing Type 1 Helper T Cell Immunity in the Female Genital Tract following Mucosal Herpes Simplex Virus 2 Vaccination
- (2017) Puja Bagri et al. JOURNAL OF VIROLOGY
- Human innate responses and adjuvant activity of TLR ligands in vivo in mice reconstituted with a human immune system
- (2017) Liang Cheng et al. VACCINE
- Multidimensional Analysis Integrating Human T-Cell Signatures in Lymphatic Tissues with Sex of Humanized Mice for Prediction of Responses after Dendritic Cell Immunization
- (2017) Valery Volk et al. Frontiers in Immunology
- Human Cytomegalovirus Induces Cellular and Humoral Virus-specific Immune Responses in Humanized BLT Mice
- (2017) Lindsey B. Crawford et al. Scientific Reports
- Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression
- (2016) Daniela C. Mónaco et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys
- (2016) Erica N. Borducchi et al. NATURE
- Erratum: Corrigendum: Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition
- (2016) Monica Vaccari et al. NATURE MEDICINE
- Impact of pre-adapted HIV transmission
- (2016) Jonathan M Carlson et al. NATURE MEDICINE
- Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus
- (2016) Jinyan Liu et al. SCIENCE
- Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway
- (2016) Varun C. Anipindi et al. PLoS Pathogens
- Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus
- (2016) Damien C. Tully et al. PLoS Pathogens
- HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells
- (2015) Anjie Zhen et al. MOLECULAR THERAPY
- Antibody responses to envelope glycoproteins in HIV-1 infection
- (2015) Dennis R Burton et al. NATURE IMMUNOLOGY
- A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells
- (2015) G. Stary et al. SCIENCE
- Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys
- (2015) D. H. Barouch et al. SCIENCE
- BLT humanized mice as a small animal model of HIV infection
- (2015) Marshall E Karpel et al. Current Opinion in Virology
- Trimmomatic: a flexible trimmer for Illumina sequence data
- (2014) Anthony M. Bolger et al. BIOINFORMATICS
- Dengue virus infection induces broadly cross-reactive human IgM antibodies that recognize intact virions in humanized BLT-NSG mice
- (2014) Smita Jaiswal et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Insufficient interleukin-12 signalling favours differentiation of human CD4+and CD8+T cells into GATA-3+and GATA-3+ T-bet+subsets in humanized mice
- (2014) Eva Billerbeck et al. IMMUNOLOGY
- HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes
- (2014) F. Pereyra et al. JOURNAL OF VIROLOGY
- Development and function of human innate immune cells in a humanized mouse model
- (2014) Anthony Rongvaux et al. NATURE BIOTECHNOLOGY
- An AAV Vector-Mediated Gene Delivery Approach Facilitates Reconstitution of Functional Human CD8+ T Cells in Mice
- (2014) Jing Huang et al. PLoS One
- Broadly neutralizing antibodies abrogate established hepatitis C virus infection
- (2014) Y. P. de Jong et al. Science Translational Medicine
- BLT-humanized C57BL/6 Rag2-/- c-/-CD47-/- mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection
- (2013) K. J. Lavender et al. BLOOD
- Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice
- (2013) Jinhee Lee et al. BMC IMMUNOLOGY
- Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys
- (2013) Dan H. Barouch et al. CELL
- Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγnull(NSG) mice engrafted with human thymus and autologous haematopoietic stem cells
- (2013) L. Covassin et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- HIV-Specific CD8+ T-Cell Immunity in Humanized Bone Marrow–Liver–Thymus Mice
- (2013) Timothy E. Dudek et al. JOURNAL OF INFECTIOUS DISEASES
- Utility of Humanized BLT Mice for Analysis of Dengue Virus Infection and Antiviral Drug Testing
- (2013) N. Frias-Staheli et al. JOURNAL OF VIROLOGY
- Immune clearance of highly pathogenic SIV infection
- (2013) Scott G. Hansen et al. NATURE
- A Humanized Mouse Model of Tuberculosis
- (2013) Veronica E. Calderon et al. PLoS One
- Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design
- (2013) Pratima Kunwar et al. PLoS One
- De novo assembly of highly diverse viral populations
- (2012) Xiao Yang et al. BMC GENOMICS
- Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice
- (2012) Smita Jaiswal et al. IMMUNOLOGY
- Alpha Interferon and HIV Infection Cause Activation of Human T Cells in NSG-BLT Mice
- (2012) B. R. Long et al. JOURNAL OF VIROLOGY
- Vaccination with Adenovirus Serotypes 35, 26, and 48 Elicits Higher Levels of Innate Cytokine Responses than Adenovirus Serotype 5 in Rhesus Monkeys
- (2012) Jeffrey E. Teigler et al. JOURNAL OF VIROLOGY
- Vaccine-induced CD8+ T cells control AIDS virus replication
- (2012) Philip A. Mudd et al. NATURE
- Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys
- (2012) Dan H. Barouch et al. NATURE
- Generation of a humanized mouse model with both human immune system and liver cells to model hepatitis C virus infection and liver immunopathogenesis
- (2012) Moses T Bility et al. Nature Protocols
- Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model
- (2012) Matthew B. Greenblatt et al. PLoS One
- FastUniq: A Fast De Novo Duplicates Removal Tool for Paired Short Reads
- (2012) Haibin Xu et al. PLoS One
- Rapid Evolution of HIV-1 to Functional CD8+ T Cell Responses in Humanized BLT Mice
- (2012) T. E. Dudek et al. Science Translational Medicine
- Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection
- (2012) Matthew R. Henn et al. PLoS Pathogens
- Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R null humanized mice
- (2011) E. Billerbeck et al. BLOOD
- A Humanized Mouse Model to Study Hepatitis C Virus Infection, Immune Response, and Liver Disease
- (2011) Michael L. Washburn et al. GASTROENTEROLOGY
- Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells
- (2011) Subhabrata Biswas et al. IMMUNOLOGY
- Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection
- (2011) Rikke Olesen et al. JOURNAL OF REPRODUCTIVE IMMUNOLOGY
- Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
- (2011) Scott G. Hansen et al. NATURE
- Protective Efficacy of Serially Up-Ranked Subdominant CD8+ T Cell Epitopes against Virus Challenges
- (2011) Eung-Jun Im et al. PLoS Pathogens
- Interleukin-17 Contributes to Generation of Th1 Immunity and Neutrophil Recruitment duringChlamydia muridarumGenital Tract Infection but Is Not Required for Macrophage Influx or Normal Resolution of Infection
- (2010) Amy M. Scurlock et al. INFECTION AND IMMUNITY
- Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response
- (2010) A. Balamurugan et al. JOURNAL OF IMMUNOLOGY
- Viral Evolution and Escape during Acute HIV‐1 Infection
- (2010) Christian L. Boutwell et al. JOURNAL OF INFECTIOUS DISEASES
- Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice
- (2010) Pablo D. Becker et al. PLoS One
- Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly
- (2010) N.-L. L. Pham et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Th17 cytokines in mucosal immunity and inflammation
- (2010) Lokesh Guglani et al. Current Opinion in HIV and AIDS
- An unanticipated lack of consensus cytotoxic T lymphocyte epitopes in HIV-1 databases: the contribution of prediction programs
- (2009) Ingrid MM Schellens et al. AIDS
- Th17 cytokines and mucosal immunity
- (2009) Patricia J. Dubin et al. IMMUNOLOGICAL REVIEWS
- The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
- (2009) Nilu Goonetilleke et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Two MHC Class I Molecules Associated with Elite Control of Immunodeficiency Virus Replication, Mamu-B*08 and HLA-B*2705, Bind Peptides with Sequence Similarity
- (2009) J. T. Loffredo et al. JOURNAL OF IMMUNOLOGY
- HIV‐1 Evolution Following Transmission to an HLA‐B*5801‐Positive Patient
- (2009) Karen A. O’Connell et al. JOURNAL OF INFECTIOUS DISEASES
- Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice
- (2009) D. M. Brainard et al. JOURNAL OF VIROLOGY
- Protective Efficacy of a Single Immunization of a Chimeric Adenovirus Vector-Based Vaccine against Simian Immunodeficiency Virus Challenge in Rhesus Monkeys
- (2009) D. H. Barouch et al. JOURNAL OF VIROLOGY
- Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses during Primary Infection Are Major Determinants of the Viral Set Point and Loss of CD4+ T Cells
- (2009) H. Streeck et al. JOURNAL OF VIROLOGY
- Adaptation of HIV-1 to human leukocyte antigen class I
- (2009) Yuka Kawashima et al. NATURE
- Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand
- (2009) Supachai Rerks-Ngarm et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genetic engineering of a modified herpes simplex virus 1 vaccine vector
- (2009) XueQiao Liu et al. VACCINE
- Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model
- (2008) N. Tonomura et al. BLOOD
- HLA class I supertypes: a revised and updated classification
- (2008) John Sidney et al. BMC IMMUNOLOGY
- Macaques vaccinated with live-attenuated SIV control replication of heterologous virus
- (2008) Matthew R. Reynolds et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients
- (2008) Paul A. Goepfert et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Reduced Viral Replication Capacity of Human Immunodeficiency Virus Type 1 Subtype C Caused by Cytotoxic-T-Lymphocyte Escape Mutations in HLA-B57 Epitopes of Capsid Protein
- (2008) C. L. Boutwell et al. JOURNAL OF VIROLOGY
- HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis
- (2008) M Juliana McElrath et al. LANCET
- Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial
- (2008) Susan P Buchbinder et al. LANCET
- Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys
- (2008) Jinyan Liu et al. NATURE
- Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2−/−γc−/− (RAG-hu) mice
- (2008) Bradford K. Berges et al. VIROLOGY
- Antiretroviral Pre-exposure Prophylaxis Prevents Vaginal Transmission of HIV-1 in Humanized BLT Mice
- (2008) Paul W Denton et al. PLOS MEDICINE
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