Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine

Reconstitution of immune cell in liver and lymph node of adult- and newborn-engrafted humanized mice

(2016) Crystal Dykstra et al.   BMC IMMUNOLOGY

Induction of an Immune-Protective T-Cell Repertoire With Diverse Genetic Coverage by a Novel Viral-Vectored Tuberculosis Vaccine in Humans

(2016) Mangalakumari Jeyanathan et al.   JOURNAL OF INFECTIOUS DISEASES

Pulmonary Tuberculosis in Humanized Mice Infected with HIV-1

(2016) Rebecca J. Nusbaum et al.   Scientific Reports

A review of clinical models for the evaluation of human TB vaccines

(2016) Matthew K. O'Shea et al.   Human Vaccines & Immunotherapeutics

Quest for Correlates of Protection against Tuberculosis

(2015) Kamlesh Bhatt et al.   Clinical and Vaccine Immunology

Animal models in tuberculosis research – where is the beef?

(2015) Henna Myllymäki et al.   Expert Opinion on Drug Discovery

Latent Mycobacterium tuberculosis Infection

(2015) Haileyesus Getahun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protection Induced by Simultaneous Subcutaneous and Endobronchial Vaccination with BCG/BCG and BCG/Adenovirus Expressing Antigen 85A against Mycobacterium bovis in Cattle

(2015) Gillian S. Dean et al.   PLoS One

Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis

(2015) Deepak Kaushal et al.   Nature Communications

Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial

(2015) Birahim Pierre Ndiaye et al.   Lancet Respiratory Medicine

AdHu5Ag85A Respiratory Mucosal Boost Immunization Enhances Protection against Pulmonary Tuberculosis in BCG-Primed Non-Human Primates

(2015) Mangalakumari Jeyanathan et al.   PLoS One

New Approaches to TB Vaccination

(2014) Zhou Xing et al.   CHEST

Challenges and responses in human vaccine development

(2014) Stefan HE Kaufmann et al.   CURRENT OPINION IN IMMUNOLOGY

Protective CD4 T Cells Targeting Cryptic Epitopes of Mycobacterium tuberculosis Resist Infection-Driven Terminal Differentiation

(2014) J. S. Woodworth et al.   JOURNAL OF IMMUNOLOGY

Safety and immunogenicity of a candidate tuberculosis vaccine MVA85A delivered by aerosol in BCG-vaccinated healthy adults: a phase 1, double-blind, randomised controlled trial

(2014) Iman Satti et al.   LANCET INFECTIOUS DISEASES

Novel Vaccination Strategies against Tuberculosis

(2014) P. Andersen et al.   Cold Spring Harbor Perspectives in Medicine

Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis

(2014) Teresa Prezzemolo et al.   Frontiers in Immunology

Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice

(2013) Jinhee Lee et al.   BMC IMMUNOLOGY

Humanized mice for the study of infectious diseases

(2013) Michael A Brehm et al.   CURRENT OPINION IN IMMUNOLOGY

Infectious diseases in humanized mice

(2013) Carol Leung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Control of Chronic Mycobacterium tuberculosis Infection by CD4 KLRG1- IL-2-Secreting Central Memory Cells

(2013) T. Lindenstrom et al.   JOURNAL OF IMMUNOLOGY

Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial

(2013) Michele D Tameris et al.   LANCET

Harnessing local and systemic immunity for vaccines against tuberculosis

(2013) P C L Beverley et al.   Mucosal Immunology

A Humanized Mouse Model of Tuberculosis

(2013) Veronica E. Calderon et al.   PLoS One

CD4+ cell-dependent granuloma formation in humanized mice infected with mycobacteria

(2013) F. Heuts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation and divergence in the transcriptional programs of the human and mouse immune systems

(2013) T. Shay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human Type 5 Adenovirus-Based Tuberculosis Vaccine Induces Robust T Cell Responses in Humans Despite Preexisting Anti-Adenovirus Immunity

(2013) F. Smaill et al.   Science Translational Medicine

Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG

(2013) Michele Tameris et al.   TUBERCULOSIS

A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data

(2013) Helen McShane et al.   TUBERCULOSIS

Within the Enemy’s Camp: contribution of the granuloma to the dissemination, persistence and transmission of Mycobacterium tuberculosis

(2013) Christopher R. Shaler et al.   Frontiers in Immunology

Understanding Delayed T-Cell Priming, Lung Recruitment, and Airway Luminal T-Cell Responses in Host Defense against Pulmonary Tuberculosis

(2012) Christopher R. Shaler et al.   Clinical & Developmental Immunology

Goats Primed with Mycobacterium bovis BCG and Boosted with a Recombinant Adenovirus Expressing Ag85A Show Enhanced Protection against Tuberculosis

(2012) Bernat Pérez de Val et al.   Clinical and Vaccine Immunology

Tuberculosis Vaccines: A Strategic Blueprint for the Next Decade

(2012) Michael J. Brennan et al.   TUBERCULOSIS

Initiation and regulation of T-cell responses in tuberculosis

(2011) K B Urdahl et al.   Mucosal Immunology

Airway luminal T cells: A newcomer on the stage of TB vaccination strategies

(2010) Mangalakumari Jeyanathan et al.   TRENDS IN IMMUNOLOGY

T cells in mycobacterial infection and disease

(2009) Andrea M Cooper   CURRENT OPINION IN IMMUNOLOGY

Comparison of the pulmonary response against lethal and non-lethal intranasal challenges with two different pneumococcal strains

(2009) Daniela M. Ferreira et al.   MICROBIAL PATHOGENESIS

Intranasal Mucosal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances the Protection of BCG-Primed Guinea Pigs against Pulmonary Tuberculosis

(2009) Zhou Xing et al.   PLoS One