Melatonin/PGC1A/UCP1 promotes tumor slimming and represses tumor progression by initiating autophagy and lipid browning

Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma

(2018) Guang-hua Xu et al.   BMC CANCER

Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway

(2018) Mingge Ding et al.   JOURNAL OF PINEAL RESEARCH

Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein

(2018) Jee-In Heo et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high fat diet-fed mice

(2018) Jie Yin et al.   JOURNAL OF PINEAL RESEARCH

Therapeutic potential of melatonin related to its role as an autophagy regulator: A review

(2018) Jose A. Boga et al.   JOURNAL OF PINEAL RESEARCH

Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge

(2017) Matthew J. Emmett et al.   NATURE

Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease

(2017) Matthias J. Betz et al.   Nature Reviews Endocrinology

Metabolic reprogramming in clear cell renal cell carcinoma

(2017) Hiromi I. Wettersten et al.   Nature Reviews Nephrology

ZLN005 protects cardiomyocytes against high glucose-induced cytotoxicity by promoting SIRT1 expression and autophagy

(2016) Wenju Li et al.   EXPERIMENTAL CELL RESEARCH

Recent insights into the function of autophagy in cancer: Table 1.

(2016) Ravi Amaravadi et al.   GENES & DEVELOPMENT

IGFBP3 and MAPK/ERK signaling mediates melatonin-induced antitumor activity in prostate cancer

(2016) Juan C. Mayo et al.   JOURNAL OF PINEAL RESEARCH

Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity

(2016) Yung-Wei Lin et al.   JOURNAL OF PINEAL RESEARCH

Cancer metastasis: Mechanisms of inhibition by melatonin

(2016) Shih-Chi Su et al.   JOURNAL OF PINEAL RESEARCH

A PGC1α-mediated transcriptional axis suppresses melanoma metastasis

(2016) Chi Luo et al.   NATURE

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

(2016) Veronica Torrano et al.   NATURE CELL BIOLOGY

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program

(2016) Audrey Sambeat et al.   Cell Reports

Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma

(2016) Kosuke Saito et al.   Scientific Reports

Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle

(2015) Anna Vainshtein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesis

(2015) T. Shpilka et al.   EMBO JOURNAL

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma

(2015) Edward L. LaGory et al.   Cell Reports

The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy

(2014) Chul-Su Yang et al.   Autophagy

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

The Browning of White Adipose Tissue: Some Burning Issues

(2014) Jan Nedergaard et al.   Cell Metabolism

A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

(2014) Michele Petruzzelli et al.   Cell Metabolism

Thermogenic Capacity Is Antagonistically Regulated in Classical Brown and White Subcutaneous Fat Depots by High Fat Diet and Endurance Training in Rats

(2014) Michelle V. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetes Mellitus is Independently Associated with an Increased Risk of Mortality in Patients with Clear Cell Renal Cell Carcinoma

(2014) Sarah P. Psutka et al.   JOURNAL OF UROLOGY

Obesity

(2014) Tony Scully   NATURE

Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity

(2014) Pengpeng Bi et al.   NATURE MEDICINE

Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro

(2014) Pan Guo et al.   TOXICOLOGICAL SCIENCES

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Transcriptional and post-translational regulation of Bim controls apoptosis in melatonin-treated human renal cancer Caki cells

(2013) Eun Jung Park et al.   JOURNAL OF PINEAL RESEARCH

Novel Small-Molecule PGC-1  Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice

(2012) L.-N. Zhang et al.   DIABETES

Metabolism of Kidney Cancer: From the Lab to Clinical Practice

(2012) Sunil Sudarshan et al.   EUROPEAN UROLOGY

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

The Epidemiology of Renal Cell Carcinoma

(2011) Börje Ljungberg et al.   EUROPEAN UROLOGY

Melatonin alleviates lipopolysaccharide-induced hepatic SREBP-1c activation and lipid accumulation in mice

(2011) Xi Chen et al.   JOURNAL OF PINEAL RESEARCH

Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice

(2010) Carrie A. Millward et al.   JOURNAL OF LIPID RESEARCH

The genetic basis of kidney cancer: a metabolic disease

(2010) W. Marston Linehan et al.   Nature Reviews Urology

Renal cell carcinoma

(2009) Brian I Rini et al.   LANCET

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Association Between Local Atherosclerosis and Renal Cell Carcinomas

(2008) Martina Hager et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL