The role of macrophage polarization on bipolar disorder: Identifying new therapeutic targets

The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression

(2016) Yong-Ku Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

So depression is an inflammatory disease, but where does the inflammation come from?

(2016) Michael Berk et al.   BMC Medicine

Damage-associated molecular patterns and immune activation in bipolar disorder

(2015) L. Stertz et al.   ACTA PSYCHIATRICA SCANDINAVICA

The association between biological rhythms, depression, and functioning in bipolar disorder: a large multi-center study

(2015) M. Pinho et al.   ACTA PSYCHIATRICA SCANDINAVICA

TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression

(2015) Tuğçe Demirtaş Şahin et al.   BEHAVIOURAL BRAIN RESEARCH

Lithium modulates the production of peripheral and cerebral cytokines in an animal model of mania induced by dextroamphetamine

(2015) Samira S Valvassori et al.   BIPOLAR DISORDERS

Endocannabinoids drive the acquisition of an alternative phenotype in microglia

(2015) M. Mecha et al.   BRAIN BEHAVIOR AND IMMUNITY

Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming

(2015) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

CSF neuroinflammatory biomarkers in bipolar disorder are associated with cognitive impairment

(2015) Sindre Rolstad et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

C-Reactive Protein Alterations in Bipolar Disorder

(2015) Aroldo A. Dargél et al.   JOURNAL OF CLINICAL PSYCHIATRY

Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome

(2015) M. D. Weber et al.   JOURNAL OF NEUROSCIENCE

Monocyte and microglial activation in patients with mood-stabilized bipolar disorder

(2015) Joel Jakobsson et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Randomized, Double-Blind, Placebo-Controlled Study of Encenicline, an α7 Nicotinic Acetylcholine Receptor Agonist, as a Treatment for Cognitive Impairment in Schizophrenia

(2015) Richard SE Keefe et al.   NEUROPSYCHOPHARMACOLOGY

Diversity and plasticity of microglial cells in psychiatric and neurological disorders

(2015) Yutaka Nakagawa et al.   PHARMACOLOGY & THERAPEUTICS

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder

(2015) Jonathan Savitz et al.   PSYCHONEUROENDOCRINOLOGY

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

(2015) John R. Kelly et al.   Frontiers in Cellular Neuroscience

Disruption in the Blood-Brain Barrier: The Missing Link between Brain and Body Inflammation in Bipolar Disorder?

(2015) Jay P. Patel et al.   NEURAL PLASTICITY

Disturbances in Hypothalamic-Pituitary-Adrenal Axis and Immunological Activity Differentiating between Unipolar and Bipolar Depressive Episodes

(2015) Karlijn Becking et al.   PLoS One

A Critical Appraisal of Neuroimaging Studies of Bipolar Disorder: Toward a New Conceptualization of Underlying Neural Circuitry and a Road Map for Future Research

(2014) Mary L. Phillips et al.   AMERICAN JOURNAL OF PSYCHIATRY

Immune dysfunction in bipolar disorder and suicide risk: is there an association between peripheral corticotropin-releasing hormone and interleukin-1β?

(2014) Xênia Monfrim et al.   BIPOLAR DISORDERS

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroinflammation in bipolar disorder – A [11C]-(R)-PK11195 positron emission tomography study

(2014) Bartholomeus C.M. (Benno) Haarman et al.   BRAIN BEHAVIOR AND IMMUNITY

In a double-blind, randomized and placebo-controlled trial, adjuvant allopurinol improved symptoms of mania in in-patients suffering from bipolar disorder

(2014) Leila Jahangard et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour

(2014) Sinead M. Gibney et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Verbal memory as a mediator in the relationship between subthreshold depressive symptoms and functional outcome in bipolar disorder

(2014) Caterina del Mar Bonnín et al.   JOURNAL OF AFFECTIVE DISORDERS

Clinical Staging in Bipolar Disorder

(2014) Adriane R. Rosa et al.   JOURNAL OF CLINICAL PSYCHIATRY

Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture

(2014) Zhenying Han et al.   JOURNAL OF NEUROCHEMISTRY

Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway

(2014) Hongquan Dong et al.   Journal of Neuroinflammation

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury

(2014) Flaubert Tchantchou et al.   NEUROPHARMACOLOGY

Blood–cerebrospinal fluid barrier dysfunction in patients with bipolar disorder in relation to antipsychotic treatment

(2014) Henrik Zetterberg et al.   PSYCHIATRY RESEARCH

The impact of microglial activation on blood-brain barrier in brain diseases

(2014) Anna Carolina Carvalho da Fonseca et al.   Frontiers in Cellular Neuroscience

Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application

(2014) C C Watkins et al.   Translational Psychiatry

Soluble interleukin-6 receptor level reflecting the illness activity in bipolar disorder

(2013) Shang-Ying Tsai et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Immune dysregulation and autoimmunity in bipolar disorder: Synthesis of the evidence and its clinical application

(2013) Sanil Rege et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Chronic Administration of Infliximab (TNF-α Inhibitor) Decreases Depression and Anxiety-like Behaviour in Rat Model of Chronic Mild Stress

(2013) Ayşe Karson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Tryptophan breakdown is increased in euthymic overweight individuals with bipolar disorder: a preliminary report

(2013) Eva Z Reininghaus et al.   BIPOLAR DISORDERS

Serotonin – Kynurenine Hypothesis of Depression: Historical Overview and Recent Developments

(2013) Gregory Oxenkrug   CURRENT DRUG TARGETS

CYTOKINE TARGETS IN THE BRAIN: IMPACT ON NEUROTRANSMITTERS AND NEUROCIRCUITS

(2013) Andrew H. Miller et al.   DEPRESSION AND ANXIETY

The absence of indoleamine 2,3-dioxygenase expression protects against NMDA receptor-mediated excitotoxicity in mouse brain

(2013) G. Mazarei et al.   EXPERIMENTAL NEUROLOGY

Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

(2013) Christian Hölscher   JOURNAL OF ENDOCRINOLOGY

Posttrauma cotreatment with lithium and valproate: reduction of lesion volume, attenuation of blood-brain barrier disruption, and improvement in motor coordination in mice with traumatic brain injury

(2013) Fengshan Yu et al.   JOURNAL OF NEUROSURGERY

In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes

(2012) M. Maes et al.   ACTA PSYCHIATRICA SCANDINAVICA

Kynurenines: from the perspective of major psychiatric disorders

(2012) Aye M. Myint   FEBS Journal

Comparison of polarization properties of human adult microglia and blood-derived macrophages

(2012) Bryce A. Durafourt et al.   GLIA

Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder

(2012) Bruno Etain et al.   HUMAN MOLECULAR GENETICS

NF-κB Drives the Synthesis of Melatonin in RAW 264.7 Macrophages by Inducing the Transcription of the Arylalkylamine-N-Acetyltransferase (AA-NAT) Gene

(2012) Sandra Marcia Muxel et al.   PLoS One

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

Regulation of Macrophage Polarization and Wound Healing

(2012) Christopher J. Ferrante et al.   Advances in Wound Care

Does stage of illness impact treatment response in bipolar disorder? Empirical treatment data and their implication for the staging model and early intervention

(2011) Michael Berk et al.   BIPOLAR DISORDERS

Role of α7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-α (TNF-α) as revealed by subtype selective agonists

(2011) Jinhe Li et al.   JOURNAL OF NEUROIMMUNOLOGY

Constant Darkness Induces IL-6-Dependent Depression-Like Behavior through the NF- B Signaling Pathway

(2011) F. J. Monje et al.   JOURNAL OF NEUROSCIENCE

PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats

(2011) Samantha L McLean et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Global burden of disease in young people aged 10–24 years: a systematic analysis

(2011) Fiona M Gore et al.   LANCET

Interleukin-1β: A New Regulator of the Kynurenine Pathway Affecting Human Hippocampal Neurogenesis

(2011) Patricia A Zunszain et al.   NEUROPSYCHOPHARMACOLOGY

Adult interleukin-6 knockout mice show compromisedneurogenesis

(2011) Kellie K. Bowen et al.   NEUROREPORT

Structural Magnetic Resonance Imaging in Bipolar Disorder: An International Collaborative Mega-Analysis of Individual Adult Patient Data

(2010) Brian Hallahan et al.   BIOLOGICAL PSYCHIATRY

The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test

(2010) Ruben Isacson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hippocampal neurogenesis as a target for the treatment of mental illness: A critical evaluation

(2010) Nathan A. DeCarolis et al.   NEUROPHARMACOLOGY

Chronic high corticosterone reduces neurogenesis in the dentate gyrus of adult male and female rats

(2010) S. Brummelte et al.   NEUROSCIENCE

Staging Bipolar Disorder

(2010) Eduard Vieta et al.   NEUROTOXICITY RESEARCH

N-acetylserotonin activates TrkB receptor in a circadian rhythm

(2010) Sung-Wuk Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

(2010) M. Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Lipopolysaccharide-Activated Microglia Induce Dysfunction of the Blood–Brain Barrier in Rat Microvascular Endothelial Cells Co-Cultured with Microglia

(2009) Noriko Sumi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease

(2009) Sehee Kim et al.   JOURNAL OF ENDOCRINOLOGY

Tumour necrosis factor-α impairs neuronal differentiation but not proliferation of hippocampal neural precursor cells: Role of Hes1

(2009) Aoife Keohane et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients

(2009) J S Rao et al.   MOLECULAR PSYCHIATRY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

The potential use of biomarkers as an adjunctive tool for staging bipolar disorder

(2009) Flávio Kapczinski et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

(2008) Wayne C. Drevets et al.   Brain Structure & Function

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder

(2008) Christine L. Miller et al.   NEUROCHEMISTRY INTERNATIONAL

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Allostatic load in bipolar disorder: Implications for pathophysiology and treatment

(2007) Flavio Kapczinski et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH