Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr virus infection of T cells

Defective Epstein–Barr virus in chronic active infection and haematological malignancy

(2019) Yusuke Okuno et al.   Nature Microbiology

Immunodeficiency and Epstein Barr virus induced lymphoproliferation caused by 4-1BB deficiency

(2019) Mohammed Alosaimi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunodeficiency, autoimmune thrombocytopenia and enterocolitis caused by autosomal recessive deficiency of PIK3CD-encoded phosphoinositide 3-kinase δ

(2019) David J Swan et al.   HAEMATOLOGICA

Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity

(2018) Emily S.J. Edwards et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Primary immunodeficiency disorder caused by phosphoinositide 3-kinase delta (PI3Kδ) deficiency

(2018) Georgios Sogkas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inherited Immunodeficiencies With High Predisposition to Epstein–Barr Virus-Driven Lymphoproliferative Diseases

(2018) Sylvain Latour et al.   Frontiers in Immunology

Epstein–Barr Virus Susceptibility in Activated PI3Kδ Syndrome (APDS) Immunodeficiency

(2018) Jean-Marie Carpier et al.   Frontiers in Immunology

Aberrant CD137 ligand expression induced by GATA6 overexpression promotes tumor progression in cutaneous T-cell lymphoma

(2018) Hiroaki Kamijo et al.   BLOOD

Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease

(2018) John E. Burke   MOLECULAR CELL

Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant

(2018) Sarah Beaussant Cohen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study

(2017) Tanya I. Coulter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dual loss of p110δ PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features

(2017) Nigel Sharfe et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human immunity against EBV—lessons from the clinic

(2017) Stuart G. Tangye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)

(2017) Georgette M. Castanedo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chronic Active Epstein–Barr Virus Disease

(2017) Hiroshi Kimura et al.   Frontiers in Immunology

Inherited CD70 deficiency in humans reveals a critical role for the CD70–CD27 pathway in immunity to Epstein-Barr virus infection

(2016) Kazushi Izawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combined immunodeficiency and Epstein-Barr virus–induced B cell malignancy in humans with inherited CD70 deficiency

(2016) Hassan Abolhassani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Immunology of Epstein-Barr Virus–Induced Disease

(2015) Graham S. Taylor et al.   Annual Review of Immunology

Novel mutations in TNFRSF7/CD27: Clinical, immunologic, and genetic characterization of human CD27 deficiency

(2015) Omar K. Alkhairy et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A human immunodeficiency caused by mutations in the PIK3R1 gene

(2014) Marie-Céline Deau et al.   JOURNAL OF CLINICAL INVESTIGATION

Epstein-Barr virus-associated T/natural killer-cell lymphoproliferative disorders

(2014) Sanghui Park et al.   JOURNAL OF DERMATOLOGY

CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation

(2014) Emmanuel Martin et al.   NATURE

Current research on chronic active Epstein-Barr virus infection in Japan

(2014) Shigeyoshi Fujiwara et al.   PEDIATRICS INTERNATIONAL

Hydroa vacciniforme-like lymphoma: a chronic EBV+ lymphoproliferative disorder with risk to develop a systemic lymphoma

(2013) L. Quintanilla-Martinez et al.   BLOOD

The contextual role of TNFR family members in CD8+T-cell control of viral infections

(2013) Michael E. Wortzman et al.   IMMUNOLOGICAL REVIEWS

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

(2013) Carrie L Lucas et al.   NATURE IMMUNOLOGY

Phosphoinositide 3-Kinase   Gene Mutation Predisposes to Respiratory Infection and Airway Damage

(2013) I. Angulo et al.   SCIENCE

Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27

(2012) E. Salzer et al.   HAEMATOLOGICA

Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency

(2012) Fabian Hauck et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases

(2011) H. Kimura et al.   BLOOD

CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia

(2011) Joris M. van Montfrans et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases

(2011) Oscar Vadas et al.   Science Signaling