Article
Chemistry, Medicinal
Hana Votavova, Zuzana Urbanova, David Kundrat, Michaela Dostalova Merkerova, Martin Vostry, Monika Hruba, Jaroslav Cermak, Monika Belickova
Summary: DFX improves hematopoiesis in anemic myelodysplastic syndrome patients by modulating immune response, suppressing negative regulators of blood cell differentiation, and upregulating heme metabolism.
Review
Immunology
Sarah Weber, Anastasia Parmon, Nina Kurrle, Frank Schnuetgen, Hubert Serve
Summary: MDS and AML patients often experience systemic iron overload issues, iron is closely associated with the pathogenesis and potential treatment strategies of the diseases, imbalances in iron homeostasis may lead to various cell death.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Caner Saygin, Lucy A. Godley
Summary: Myelodysplastic syndrome (MDS) is a bone marrow disease characterized by the inability to produce normal numbers of blood cells. Different types of MDS are driven by distinct biological pathways, with advancements in treatment strategies based on molecular understanding. The recognition of precursor conditions may allow for strategies to delay or prevent MDS development.
Article
Hematology
Vladimir Riabov, Maximilian Mossner, Alexandra Stoehr, Johann-Christoph Jann, Alexander Streuer, Nanni Schmitt, Antje Knaflic, Verena Nowak, Nadine Weimer, Julia Oblaender, Iris Palme, Christiane Schumann, Claudia D. Baldus, Torsten J. Schulze, Patrick Wuchter, Henning Roehl, Ahmed Jawhar, Christel Weiss, Tobias Boch, Georgia Metzgeroth, Martin Neumann, Wolf-Karsten Hofmann, Florian Nolte, Daniel Nowak
Summary: The expression of ERFE and GDF15 in MDS patients was found to be highly aberrant, with ERFE expression unexpectedly relevant for MDS prognosis. ERFE overexpression predicted superior overall survival in certain MDS subgroups, suggesting a possible involvement of ERFE in the molecular pathogenesis of MDS.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Hematology
Julia Stomper, Paulina Richter-Pechanska, Dietmar Pfeifer, Immacolata Andolfo, Achille Iolascon, Martina U. Muckenthaler, Michael Luebbert
Summary: This study describes sustained and dose-dependent erythroid improvement in a patient with constitutional variants in the TRIB2 and ABCB6 genes after treatment with DFX.
Article
Chemistry, Medicinal
Katarzyna Malarz, Dawid Zych, Robert Gawecki, Michal Kuczak, Robert Musiol, Anna Mrozek-Wilczkiewicz
Summary: Terpyridine derivatives, particularly the newly synthesized 4'-phenyl-2,2':6',2 ''-terpyridine group, exhibit high anti-proliferative activity and selective toxicity towards various types of cancer cells. Molecular biology studies have shown their impact on cell cycle inhibition, apoptosis, and autophagy pathways, with a specific focus on DNA and ROS-related targets.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui
Summary: Mitochondria, essential organelles for energy production in eukaryotes, generate reactive oxygen species during the process which play pivotal roles in cell signaling and iron homeostasis regulation. The regulation of iron transportation, involving proteins like HCP1, DMT1, and mitoferrin, is increasingly understood in relation to mitochondrial reactive oxygen species and diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Zhi Liu, Gregory A. Simchick, Jing Qiao, Morgan M. Ashcraft, Shuolin Cui, Tamas Nagy, Qun Zhao, May P. Xiong
Summary: A nanochelator system utilizing the physiological environment of iron overload was developed to improve iron elimination and pharmacokinetic properties in mice, showing promising results for iron chelation therapy with no adverse effects observed in toxicity studies. This ROS-responsive nanochelator design could be a safe alternative for effectively removing iron chelates from the body in iron chelation therapy regimens requiring repeated dosing.
Review
Oncology
Cecilia H. Kim, Heather A. Leitch
Summary: Iron overload-induced reactive oxygen species affect cellular activities, leading to dysfunction in hematopoietic stem cells and other cells, exacerbating the pathophysiology of myelodysplastic syndromes.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Charlene B. Van Buiten, Guojun Wu, Yan Y. Lam, Liping Zhao, Ilya Raskin
Summary: Fe0 treatment reduces luminal ROS in the gastrointestinal tract, improves metabolic outcomes in obese and hyperglycemic animals, promotes the growth of beneficial bacteria, and suppresses detrimental populations.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Zhuobin Xu, Yufei Zhu, Mengke Xie, Kankan Liu, Liangliang Cai, Huihui Wang, Dandan Li, Hao Chen, Lizeng Gao
Summary: This study synthesized mackinawite nanozymes (GFeSNs) from glutathione and iron ions, and found that GFeSNs have broad-spectrum antioxidant properties and can significantly improve the treatment outcomes of acute kidney injury (AKI) by scavenging reactive oxygen species (ROS).
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Michele Cerasuolo, Irene Di Meo, Maria Chiara Auriemma, Francesca Trojsi, Maria Ida Maiorino, Mario Cirillo, Fabrizio Esposito, Rita Polito, Anna Maria Colangelo, Giuseppe Paolisso, Michele Papa, Maria Rosaria Rizzo
Summary: Neurodegeneration is a complex process involving multiple mechanisms, with diseases like Parkinson's, multiple sclerosis, Alzheimer's, prion diseases, and ALS being examples. Iron overload has been identified as a potential cause of neurodegeneration, with dysregulated iron metabolism and increased oxidative stress being common in these diseases. Alzheimer's, in particular, shows increased iron content in vulnerable brain regions, leading to mitochondrial alterations and lack of antioxidant defenses. Iron metabolism and ferroptosis play a significant role in diabetes-induced cognitive decline, and iron chelators offer a promising therapeutic approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Giuseppe A. Palumbo, Sara Galimberti, Wilma Barcellini, Daniela Cilloni, Nicola Di Renzo, Elena Maria Elli, Carlo Finelli, Luca Maurillo, Alessandra Ricco, Pellegrino Musto, Rodolfo Russo, Roberto Latagliata
Summary: Iron chelation therapy has become a mainstay in heavily transfused hematological patients to reduce iron overload and prevent organ damage. It is widely used in thalassemic patients and low-risk MDS patients, and has been proposed for high-risk MDS patients and other disorders requiring significant transfusion support. Data suggests that iron toxicity exacerbates anemia and clinical comorbidities, and with the availability of approved oral iron chelators, a larger use of ICT is envisioned in the near future.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Medicinal
Zahra Shaghaghi, Shokouh Motieian, Maryam Alvandi, Amirhossein Yazdi, Bahareh Asadzadeh, Soghra Farzipour, Sahar Abbasi
Summary: Ferroptosis is a novel form of programmed cell death that occurs due to an increase in iron levels and is implicated in various cardiovascular diseases. Inhibiting cardiac ferroptosis holds potential as a therapeutic method for cardiovascular disorders, but further understanding of the regulatory mechanisms of ferroptosis activation is needed.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Ana Cristina Goncalves, Raquel Alves, Ines Baldeiras, Joana Jorge, Barbara Marques, Artur Paiva, Barbara Oliveiros, Emilia Cortesao, Jose Manuel Nascimento Costa, Ana Bela Sarmento-Ribeiro
Summary: Oxidative stress is correlated with the development of various cancers, including myelodysplastic syndromes (MDS), and treatment resistance. This study found that lower-risk MDS patients who responded to ESA treatment had lower oxidative stress levels, with plasmatic peroxides levels being a good predictive biomarker for ESA treatment response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
