Ontogeny of Phase I Metabolism of Drugs

Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-hydroxylation is an In Vitro Marker of CYP3A7 Activity

(2019) Yu-Jie Chen et al.   DRUG METABOLISM AND DISPOSITION

Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method

(2019) E. A. M. Calvier et al.   AAPS Journal

Intravenous Paracetamol Dosing Guidelines for Pain Management in (pre)term Neonates Using the Paediatric Study Decision Tree

(2018) P. Mian et al.   CURRENT PHARMACEUTICAL DESIGN

Developmental Pharmacokinetics in Neonates: Maturational Changes and Beyond

(2018) Karel Allegaert et al.   CURRENT PHARMACEUTICAL DESIGN

Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing

(2018) Tamorah Lewis et al.   PEDIATRIC RESEARCH

Breath test using 13C methacetin does not seem to be useful in the assessment of liver function in girls with anorexia nervosa: a case control study

(2018) Katarzyna Górowska-Kowolik et al.   BMC GASTROENTEROLOGY

Developmental Changes in Pharmacokinetics and Pharmacodynamics

(2018) John van den Anker et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Non-maturational covariates for dynamic systems pharmacology models in neonates, infants, and children: Filling the gaps beyond developmental pharmacology

(2017) Karel Allegaert et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Evidence-based drug treatment for special patient populations through model-based approaches

(2017) Elke H.J. Krekels et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver

(2017) Meijuan Xu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Polymorphisms in CYP2C9 are associated with response to indomethacin among neonates with patent ductus arteriosus

(2017) Caitlin J Smith et al.   PEDIATRIC RESEARCH

Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill Children

(2016) Nienke J. Vet et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The effect of inflammation on voriconazole trough concentrations in children

(2016) Mendy ter Avest et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Tacrolimus dose requirements in paediatric renal allograft recipients are characterized by a biphasic course determined by age and bone maturation

(2016) Noël Knops et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cytochrome P450 2C9 gene polymorphism and warfarin maintenance dosage in pediatric patients: A systematic review and meta-analysis

(2016) Jinhua Zhang et al.   Cardiovascular Therapeutics

The Effect of Weight and CYP3A5 Genotype on the Population Pharmacokinetics of Tacrolimus in Stable Paediatric Renal Transplant Recipients

(2016) Agnieszka A. Prytuła et al.   CLINICAL PHARMACOKINETICS

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants

(2016) Mikael Boberg et al.   DRUG METABOLISM AND DISPOSITION

SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants

(2016) Maja Matic et al.   THERAPEUTIC DRUG MONITORING

Addressing phenoconversion: the Achilles' heel of personalized medicine

(2015) Rashmi R. Shah et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Neonatal drug therapy: The first frontier of therapeutics for children

(2015) K Allegaert et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Clinical Pharmacology of Paracetamol in Neonates: A Review

(2015) Gian Maria Pacifici et al.   CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL

Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants

(2015) Elke H. J. Krekels et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Meta-analysis of hepatic cytochrome P450 ontogeny to underwrite the prediction of pediatric pharmacokinetics using physiologically based pharmacokinetic modeling

(2015) Vijay V. Upreti et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Content and activity of human liver microsomal protein and prediction of individual hepatic clearance in vivo

(2015) Haifeng Zhang et al.   Scientific Reports

Changes in Individual Drug-Independent System Parameters during Virtual Paediatric Pharmacokinetic Trials: Introducing Time-Varying Physiology into a Paediatric PBPK Model

(2014) Khaled Abduljalil et al.   AAPS Journal

Microsomal protein per gram of liver (MPPGL) in paediatric biliary atresia patients

(2014) Lies De Bock et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

A Re-evaluation and Validation of Ontogeny Functions for Cytochrome P450 1A2 and 3A4 Based on In Vivo Data

(2014) Farzaneh Salem et al.   CLINICAL PHARMACOKINETICS

Developmental Changes in the Expression and Function of Cytochrome P450 3A Isoforms: Evidence from In Vitro and In Vivo Investigations

(2013) Ibrahim Ince et al.   CLINICAL PHARMACOKINETICS

Valproic acid pathway

(2013) Yogita Ghodke-Puranik et al.   Pharmacogenetics and Genomics

Low but Inducible Contribution of Renal Elimination to Clearance of Propylene Glycol in Preterm and Term Neonates

(2013) Roosmarijn F. W. De Cock et al.   THERAPEUTIC DRUG MONITORING

Interpreting Pharmacogenetic Data in the Developing Neonate: The Challenge of Hitting a Moving Target

(2012) J S Leeder et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Developmental expression of drug metabolizing enzymes: Impact on disposition in neonates and young children

(2012) R.N. Hines   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous 13C-Methacetin Breath Test Differentiates Biliary Atresia From Other Causes of Neonatal Cholestasis

(2012) Eyal Shteyer et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Safe and Effective Variability—A Criterion for Dose Individualization

(2012) Nicholas H.G. Holford et al.   THERAPEUTIC DRUG MONITORING

Impact of the CYP2C19*17 Allele on the Pharmacokinetics of Omeprazole and Pantoprazole in Children: Evidence for a Differential Effect

(2010) G. L. Kearns et al.   DRUG METABOLISM AND DISPOSITION

Hormonal Regulation of Hepatic Drug-Metabolizing Enzyme Activity During Adolescence

(2008) MJ Kennedy   CLINICAL PHARMACOLOGY & THERAPEUTICS

Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling

(2008) Z. E. Barter et al.   DRUG METABOLISM AND DISPOSITION

Postmenstrual Age and CYP2D6 Polymorphisms Determine Tramadol O-demethylation in Critically Ill Neonates and Infants

(2008) Karel Allegaert et al.   PEDIATRIC RESEARCH