Regulatory T Cells: the Many Faces of Foxp3

Mitochondrial complex III is essential for suppressive function of regulatory T cells

(2019) Samuel E. Weinberg et al.   NATURE

Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function

(2019) Catherine Konopacki et al.   NATURE IMMUNOLOGY

Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells

(2019) Billur Akkaya et al.   NATURE IMMUNOLOGY

Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels

(2019) Martin Vaeth et al.   Nature Communications

The FOXP3Δ2 isoform supports regulatory T cell development and protects against severe IPEX

(2019) Katie Frith et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells

(2019) Frédéric Van Gool et al.   IMMUNITY

Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance

(2019) Zinan Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel human IL2RB mutation results in T and NK cell–driven immune dysregulation

(2019) Isabel Z. Fernandez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy

(2019) Azza Abdel-Gadir et al.   NATURE MEDICINE

Functional reprogramming of regulatory T cells in the absence of Foxp3

(2019) Louis-Marie Charbonnier et al.   NATURE IMMUNOLOGY

Patients withCD3Gmutations reveal a role for human CD3γ in Tregdiversity and suppressive function

(2018) Jared H. Rowe et al.   BLOOD

Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects

(2018) Charlotte Schwab et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation

(2018) Fayhan J. Alroqi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study

(2018) Federica Barzaghi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy

(2018) Daniel Kotlarz et al.   NATURE GENETICS

Regulatory T cells in autoimmune disease

(2018) Margarita Dominguez-Villar et al.   NATURE IMMUNOLOGY

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

(2018) Eleonora Trotta et al.   NATURE MEDICINE

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes

(2018) Jonathan T. Sockolosky et al.   SCIENCE

Dominant-negative STAT5B mutations cause growth hormone insensitivity with short stature and mild immune dysregulation

(2018) Jürgen Klammt et al.   Nature Communications

Emerging Functions of Regulatory T Cells in Tissue Homeostasis

(2018) Amit Sharma et al.   Frontiers in Immunology

RAG Deficiency: Two Genes, Many Diseases

(2018) Ottavia M. Delmonte et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy

(2018) Jamie B. Spangler et al.   JOURNAL OF IMMUNOLOGY

RAG gene defects at the verge of immunodeficiency and immune dysregulation

(2018) Anna Villa et al.   IMMUNOLOGICAL REVIEWS

Tregopathies: Monogenic diseases resulting in regulatory T-cell deficiency

(2018) Alma-Martina Cepika et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses

(2017) Joanne E. Konkel et al.   IMMUNITY

Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells

(2017) Norihito Hayatsu et al.   IMMUNITY

DOCK8 Deficiency Presenting as an IPEX-Like Disorder

(2017) Fayhan J. Alroqi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Stability and function of regulatory T cells expressing the transcription factor T-bet

(2017) Andrew G. Levine et al.   NATURE

Regulatory T cells promote myelin regeneration in the central nervous system

(2017) Yvonne Dombrowski et al.   NATURE NEUROSCIENCE

FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes

(2017) Ho-Keun Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A human immunodeficiency syndrome caused by mutations in CARMIL2

(2017) T. Schober et al.   Nature Communications

From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation

(2016) Rosa Bacchetta et al.   Annals of the New York Academy of Sciences

Tissue Tregs

(2016) Marisella Panduro et al.   Annual Review of Immunology

The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements

(2016) Claudio Procaccini et al.   IMMUNITY

FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy

(2016) Willem S. Lexmond et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual T cell– and B cell–intrinsic deficiency in humans with biallelicRLTPRmutations

(2016) Yi Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity

(2016) Chong T. Luo et al.   NATURE

Classical dendritic cells are required for dietary antigen–mediated induction of peripheral Treg cells and tolerance

(2016) Daria Esterházy et al.   NATURE IMMUNOLOGY

An essential role for the IL-2 receptor in Treg cell function

(2016) Takatoshi Chinen et al.   NATURE IMMUNOLOGY

Immunometabolism of regulatory T cells

(2016) Ryan Newton et al.   NATURE IMMUNOLOGY

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells

(2016) Amir Hossein Massoud et al.   NATURE MEDICINE

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

(2016) Jing He et al.   NATURE MEDICINE

A potential founder variant inCARMIL2/RLTPRin three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction

(2016) Hanne S. Sorte et al.   Molecular Genetics & Genomic Medicine

Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE

(2015) Jens Y Humrich et al.   ANNALS OF THE RHEUMATIC DISEASES

Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

(2015) C. G. Brunstein et al.   BLOOD

Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry

(2015) Saskia J. A. M. Santegoets et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

Regulatory T Cell Reprogramming toward a Th2-Cell-like Lineage Impairs Oral Tolerance and Promotes Food Allergy

(2015) Magali Noval Rivas et al.   IMMUNITY

Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like disorder caused by loss-of-function mutations in LRBA

(2015) Louis-Marie Charbonnier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients

(2015) Michelle Rosenzwajg et al.   JOURNAL OF AUTOIMMUNITY

IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1

(2015) Peter Hsu et al.   JOURNAL OF IMMUNOLOGY

Control of peripheral tolerance by regulatory T cell–intrinsic Notch signaling

(2015) Louis-Marie Charbonnier et al.   NATURE IMMUNOLOGY

The microbiota regulates type 2 immunity through ROR t+ T cells

(2015) C. Ohnmacht et al.   SCIENCE

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

(2015) E. Sefik et al.   SCIENCE

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Function of a Foxp3 cis -Element in Protecting Regulatory T Cell Identity

(2014) Xudong Li et al.   CELL

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

(2014) Yongqiang Feng et al.   CELL

Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II

(2014) Bitao Liang et al.   JOURNAL OF IMMUNOLOGY

TCR Signaling Events Are Required for Maintaining CD4 Regulatory T Cell Numbers and Suppressive Capacities in the Periphery

(2014) Arnaud Delpoux et al.   JOURNAL OF IMMUNOLOGY

Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells

(2014) Aaron Arvey et al.   NATURE IMMUNOLOGY

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

(2014) Desirée Schubert et al.   NATURE MEDICINE

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

(2014) S. A. Villalta et al.   Science Translational Medicine

Effects of Low-Dose Recombinant Interleukin 2 to Promote T-Regulatory Cells in Alopecia Areata

(2014) Emeline Castela et al.   JAMA Dermatology

CD45RA–Foxp3high activated/effector regulatory T cells in the CCR7+CD45RA–CD27+CD28+central memory subset are decreased in peripheral blood from patients with rheumatoid arthritis

(2013) Fumichika Matsuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity

(2013) Kevin Goudy et al.   CLINICAL IMMUNOLOGY

Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells

(2013) Jennifer A. Jenks et al.   CLINICAL IMMUNOLOGY

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders

(2013) James W. Verbsky et al.   CURRENT OPINION IN PEDIATRICS

Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation–polyendocrinopathy–enteropathy–X-linked–like syndrome

(2013) Gulbu Uzel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lung-resident tissue macrophages generate Foxp3+regulatory T cells and promote airway tolerance

(2013) Pejman Soroosh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

(2013) Kate S. Smigiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

TGF  Receptor Mutations Impose a Strong Predisposition for Human Allergic Disease

(2013) P. A. Frischmeyer-Guerrerio et al.   Science Translational Medicine

Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial

(2013) Agnès Hartemann et al.   Lancet Diabetes & Endocrinology

IL-10 and IL-10 receptor defects in humans

(2012) Erik-Oliver Glocker et al.   Annals of the New York Academy of Sciences

Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance

(2012) Angelina M. Bilate et al.   Annual Review of Immunology

Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion

(2012) Y. C. Kim et al.   BLOOD

Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

(2012) Robert M. Samstein et al.   CELL

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2

(2012) Meghan A. Koch et al.   IMMUNITY

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

(2012) Naganari Ohkura et al.   IMMUNITY

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+T reg cells

(2012) Jonathan M. Weiss et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

(2012) Mahesh Yadav et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The immunogenetics of immune dysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome

(2012) Eva d'Hennezel et al.   JOURNAL OF MEDICAL GENETICS

Novel Foxo1-dependent transcriptional programs control Treg cell function

(2012) Weiming Ouyang et al.   NATURE

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

Transcription factor Foxp3 and its protein partners form a complex regulatory network

(2012) Dipayan Rudra et al.   NATURE IMMUNOLOGY

Treg Cells, Life History, and Diversity

(2012) C. Benoist et al.   Cold Spring Harbor Perspectives in Biology

Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome: A Paradigm of Immunodeficiency with Autoimmunity

(2012) Federica Barzaghi et al.   Frontiers in Immunology

A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity

(2011) Dipica Haribhai et al.   IMMUNITY

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

(2011) Ashutosh Chaudhry et al.   IMMUNITY

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

(2011) Yunqi Wang et al.   IMMUNITY

Peripheral education of the immune system by colonic commensal microbiota

(2011) Stephanie K. Lathrop et al.   NATURE

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

(2011) David Saadoun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Foxo Transcription Factors Control Regulatory T Cell Development and Function

(2010) Yann M. Kerdiles et al.   IMMUNITY

In vivo regulation of the allergic response by the IL-4 receptor α chain immunoreceptor tyrosine-based inhibitory motif

(2010) Raffi Tachdjian et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling

(2010) Clinton B. Mathias et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulatory T Cells Interfere with Glutathione Metabolism in Dendritic Cells and T Cells

(2010) Zhonghua Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

(2010) Weiming Ouyang et al.   NATURE IMMUNOLOGY

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

T Cell Receptor CDR3 Sequence but Not Recognition Characteristics Distinguish Autoreactive Effector and Foxp3+ Regulatory T Cells

(2009) Xin Liu et al.   IMMUNITY

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

(2009) Maria A. Curotto de Lafaille et al.   IMMUNITY

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

(2009) Ye Zheng et al.   NATURE

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner

(2009) A. Chaudhry et al.   SCIENCE

DNA methylation controls Foxp3 gene expression

(2008) Julia K. Polansky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: Inconsistent correlation between forkhead box protein 3 expression and disease severity

(2008) Eleonora Gambineri et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

(2008) Y. Onishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE