Physiologically Relevant Oxygen Concentration (6% O2) as an Important Component of the Microenvironment Impacting Melanoma Phenotype and Melanoma Response to Targeted Therapeutics In Vitro

Targeting the ERK Signaling Pathway in Melanoma

(2019) Paola Savoia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Relevance of Oxygen Concentration in Stem Cell Culture for Regenerative Medicine

(2019) Cristina Mas-Bargues et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMPK directly activates mTORC2 to promote cell survival during acute energetic stress

(2019) Dubek Kazyken et al.   Science Signaling

Plasticity of Drug-Naïve and Vemurafenib- or Trametinib-Resistant Melanoma Cells in Execution of Differentiation/Pigmentation Program

(2019) Malgorzata Czyz et al.   Journal of Oncology

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

Cancer stem cells and hypoxia-inducible factors (Review)

(2018) Wei-Wei Tong et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

PGC-1α as a Pivotal Factor in Lipid and Metabolic Regulation

(2018) Ching-Feng Cheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Whole-exome sequencing reveals novel genetic variants associated with diverse phenotypes of melanoma cells

(2018) Mariusz L. Hartman et al.   MOLECULAR CARCINOGENESIS

Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo

(2018) Seung-Shick Shin et al.   Oncogenesis

MAPK pathway in melanoma part II—secondary and adaptive resistance mechanisms to BRAF inhibition

(2017) Teresa Amaral et al.   EUROPEAN JOURNAL OF CANCER

The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate

(2017) Pranavi Koppula et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vemurafenib and trametinib reduce expression of CTGF and IL-8 in V600EBRAF melanoma cells

(2017) Mariusz L Hartman et al.   LABORATORY INVESTIGATION

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology

(2017) Akinori Kawakami et al.   LABORATORY INVESTIGATION

Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

(2017) Rajasekharan Somasundaram et al.   Nature Communications

Maintenance of redox homeostasis by hypoxia-inducible factors

(2017) Debangshu Samanta et al.   Redox Biology

Exogenous growth factors bFGF, EGF and HGF do not influence viability and phenotype of V600EBRAF melanoma cells and their response to vemurafenib and trametinib in vitro

(2017) Izabela Zalesna et al.   PLoS One

The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4

(2016) Céline Pinheiro et al.   CELL CYCLE

Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors

(2016) Gao Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

CD271 Down-Regulation Promotes Melanoma Progression and Invasion in Three-Dimensional Models and in Zebrafish

(2016) Annalisa Saltari et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hypoxia-Driven Mechanism of Vemurafenib Resistance in Melanoma

(2016) Y. Qin et al.   MOLECULAR CANCER THERAPEUTICS

Hypoxia increases the heterogeneity of melanoma cell populations and affects the response to vemurafenib

(2016) DANIELA PUCCIARELLI et al.   Molecular Medicine Reports

A PGC1α-mediated transcriptional axis suppresses melanoma metastasis

(2016) Chi Luo et al.   NATURE

Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived xenografts

(2016) Joydeep Bhadury et al.   Oncotarget

Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance

(2015) Willy Hugo et al.   CELL

The hitchhiker’s guide to PGC-1α isoform structure and biological functions

(2015) Vicente Martínez-Redondo et al.   DIABETOLOGIA

Hypoxia-Inducible Factor-1αand CD271 inversely correlate with melanoma invasiveness

(2015) Alessandra Marconi et al.   EXPERIMENTAL DERMATOLOGY

Pro-Survival Role of MITF in Melanoma

(2015) Mariusz L. Hartman et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MITF Modulates Therapeutic Resistance through EGFR Signaling

(2015) Zhenyu Ji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vemurafenib resistance reprograms melanoma cells towards glutamine dependence

(2015) Jenny E Hernandez-Davies et al.   Journal of Translational Medicine

Phenotypic diversity of patient-derived melanoma populations in stem cell medium

(2015) Malgorzata Sztiller-Sikorska et al.   LABORATORY INVESTIGATION

Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells

(2015) Franziska Baenke et al.   Molecular Oncology

Molecular drivers of cellular metabolic reprogramming in melanoma

(2015) Cecilie Abildgaard et al.   TRENDS IN MOLECULAR MEDICINE

Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells

(2015) Andreas Koch et al.   Oncotarget

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene

(2015) Arnaldur Hall et al.   Oncotarget

CD271 is an imperfect marker for melanoma initiating cells

(2015) Yann Cheli et al.   Oncotarget

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

(2014) S R McKeown   BRITISH JOURNAL OF RADIOLOGY

Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1  and Oxidative Phosphorylation in Melanoma

(2014) Y. N. V. Gopal et al.   CANCER RESEARCH

MITF in melanoma: mechanisms behind its expression and activity

(2014) Mariusz L. Hartman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ovarian tumor-initiating cells display a flexible metabolism

(2014) Angela S. Anderson et al.   EXPERIMENTAL CELL RESEARCH

Targeting glutamine transport to suppress melanoma cell growth

(2014) Qian Wang et al.   INTERNATIONAL JOURNAL OF CANCER

The Pyruvate Dehydrogenase Complexes: Structure-based Function and Regulation

(2014) Mulchand S. Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Gene Expression Profiling Identifies Microphthalmia-Associated Transcription Factor (MITF) and Dickkopf-1 (DKK1) as Regulators of Microenvironment-Driven Alterations in Melanoma Phenotype

(2014) Mariusz L. Hartman et al.   PLoS One

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

(2014) Judith Müller et al.   Nature Communications

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

Culture under low physiological oxygen conditions improves the stemness and quality of induced pluripotent stem cells

(2013) Chao-Wan Guo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoxia Contributes to Melanoma Heterogeneity by Triggering HIF1α-Dependent Phenotype Switching

(2013) Daniel S. Widmer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing

(2013) H Vörsmann et al.   Cell Death & Disease

Inactivation of the HIF-1 /PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants

(2012) J. Kluza et al.   CANCER RESEARCH

Sphere formation and self-renewal capacity of melanoma cells is affected by the microenvironment

(2012) Malgorzata Sztiller-Sikorska et al.   MELANOMA RESEARCH

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

(2011) Aude Carreau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

HIF-1α in Epidermis: Oxygen Sensing, Cutaneous Angiogenesis, Cancer, and Non-Cancer Disorders

(2011) Hamid R. Rezvani et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fibroblasts Contribute to Melanoma Tumor Growth and Drug Resistance

(2011) Edward H. Flach et al.   MOLECULAR PHARMACEUTICS

A High Proliferative Index of Recurrent Melanoma Is Associated with Worse Survival

(2011) Ting J. Tu et al.   ONCOLOGY

Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF

(2011) E. Feige et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

(2011) J.-P. Gillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Constitutive HIF-1 activity in malignant melanoma

(2010) Silke Kuphal et al.   EUROPEAN JOURNAL OF CANCER

Expression and function of hypoxia inducible factor-1 alpha in human melanoma under non-hypoxic conditions

(2009) Caroline N Mills et al.   Molecular Cancer

Hypoxia, melanocytes and melanoma - survival and tumor development in the permissive microenvironment of the skin

(2009) Barbara Bedogni et al.   Pigment Cell & Melanoma Research