Paraoxonase-1 as a Regulator of Glucose and Lipid Homeostasis: Impact on the Onset and Progression of Metabolic Disorders

Alzheimer’s Disease Markers in Aged ApoE-PON1 Deficient Mice

(2019) Chandrakala Aluganti Narasimhulu et al.   JOURNAL OF ALZHEIMERS DISEASE

Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation

(2018) Samar H Ibrahim et al.   GUT

Circulating ApoJ is closely associated with insulin resistance in human subjects

(2018) Ji A. Seo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Paraoxonases: metabolic role and pharmacological projection

(2018) Carlos Moya et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Incidence and Trend of Type 1 Diabetes and the Underlying Environmental Determinants

(2018) Ying Xia et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Serum paraoxonase 1 activity is paradoxically maintained in nonalcoholic fatty liver disease despite low HDL cholesterol

(2018) Eline H. van den Berg et al.   JOURNAL OF LIPID RESEARCH

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis

(2017) Anna M. Diehl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Paraoxonase, arylesterase and lactonase activities of paraoxonase-1 (PON1) in obese and severely obese women

(2017) Carlo Cervellati et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Impact of menopause and diabetes on atherogenic lipid profile: is it worth to analyse lipoprotein subfractions to assess cardiovascular risk in women?

(2017) Marília Izar Helfenstein Fonseca et al.   Diabetology & Metabolic Syndrome

Glycation of paraoxonase 1 by high glucose instigates endoplasmic reticulum stress to induce endothelial dysfunction in vivo

(2017) Wei Yu et al.   Scientific Reports

Paraoxonase-1 activities in children and adolescents with type 1 diabetes mellitus

(2016) Elena C. Craciun et al.   ACTA BIOCHIMICA POLONICA

Paraoxonases-1, -2 and -3: What are their functions?

(2016) Clement E. Furlong et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Serum Paraoxonase-1 Levels are Significantly Decreased in the Presence of Insulin Resistance

(2016) A. Gateva et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin as a weapon

(2016) Samuel D. Robinson et al.   TOXICON

Oxidative Stress-Related Genes in Type 2 Diabetes: Association Analysis and Their Clinical Impact

(2015) Suranjana Ray Haldar et al.   BIOCHEMICAL GENETICS

Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies

(2015) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

Human paraoxonase-1 (PON1): Gene structure and expression, promiscuous activities and multiple physiological roles

(2015) Mike Mackness et al.   GENE

Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management

(2015) Stuart McPherson et al.   JOURNAL OF HEPATOLOGY

Cystine accumulation attenuates insulin release from the pancreatic β-cell due to elevated oxidative stress and decreased ATP levels

(2015) Bernadette McEvoy et al.   JOURNAL OF PHYSIOLOGY-LONDON

PON1 and Mediterranean Diet

(2015) José Lou-Bonafonte et al.   Nutrients

How Inflammation Impinges on NAFLD: A Role for Kupffer Cells

(2015) Nádia Duarte et al.   Biomed Research International

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Obesity, insulin resistance and comorbidities ? Mechanisms of association

(2014) Ana Valeria B. Castro et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Apoptosis of Beta Cells in Diabetes Mellitus

(2014) Rachakatla Anuradha et al.   DNA AND CELL BIOLOGY

Plasma Clusterin (ApoJ) Levels Are Associated with Adiposity and Systemic Inflammation

(2014) Jong Chul Won et al.   PLoS One

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

(2014) Hannele Yki-Järvinen   Lancet Diabetes & Endocrinology

Quantification of the arylesterase activity of paraoxonase-1 in human blood

(2013) Clara G. Dias et al.   Analytical Methods

Paraoxonase1 (PON1) reduces insulin resistance in mice fed a high-fat diet, and promotes GLUT4 overexpression in myocytes, via the IRS-1/Akt pathway

(2013) Marie Koren-Gluzer et al.   ATHEROSCLEROSIS

Extra-virgin olive oil consumption reduces the age-related decrease in HDL and paraoxonase 1 anti-inflammatory activities

(2013) Soumaya Loued et al.   BRITISH JOURNAL OF NUTRITION

New insights into osteoporosis: the bone-fat connection

(2013) M. Kawai et al.   JOURNAL OF INTERNAL MEDICINE

The Importance of Paraoxonase 1 Activity, Nitric Oxide and Lipid Peroxidation in Hepatosteatosis

(2013) A Atamer et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Paraoxonase-1 Deficiency Is Associated with Severe Liver Steatosis in Mice Fed a High-fat High-cholesterol Diet: A Metabolomic Approach

(2013) Anabel García-Heredia et al.   JOURNAL OF PROTEOME RESEARCH

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

(2013) Steven E Kahn et al.   LANCET

Paraoxonase-1 Inhibits Oxidized Low-Density Lipoprotein-Induced Metabolic Alterations and Apoptosis in Endothelial Cells: A Nondirected Metabolomic Study

(2013) Anabel García-Heredia et al.   MEDIATORS OF INFLAMMATION

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

Risk of postprandial insulin resistance: The liver/vagus rapport

(2013) Maria Paula Macedo et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

The physiological roles of apolipoprotein J/clusterin in metabolic and cardiovascular diseases

(2013) S. Park et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Obesity, insulin resistance, NASH and hepatocellular carcinoma

(2013) Jun Yu et al.   SEMINARS IN CANCER BIOLOGY

Adipokines Mediate Inflammation and Insulin Resistance

(2013) Hyokjoon Kwon et al.   Frontiers in Endocrinology

Tissue–Specific Insulin Signaling, Metabolic Syndrome, and Cardiovascular Disease

(2012) Christian Rask-Madsen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Evolution of Inflammatory Diseases

(2012) Daniel Okin et al.   CURRENT BIOLOGY

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace

(2012) György Baffy et al.   JOURNAL OF HEPATOLOGY

Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders

(2011) Lale Ozcan et al.   Annual Review of Medicine

The Human Paraoxonase Gene Cluster As a Target in the Treatment of Atherosclerosis

(2011) Zhi-Gang She et al.   ANTIOXIDANTS & REDOX SIGNALING

The antioxidant HDL-associated paraoxonase-1 (PON1) attenuates diabetes development and stimulates β-cell insulin release

(2011) Marie Koren-Gluzer et al.   ATHEROSCLEROSIS

Paraoxonase 1 genetic polymorphisms and susceptibility to breast cancer: A meta-analysis

(2011) Mostafa Saadat   Cancer Epidemiology

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Determinants of Paraoxonase 1 Status: Genes, Drugs and Nutrition

(2011) C. Schrader et al.   CURRENT MEDICINAL CHEMISTRY

Effect of dietary lipids on paraoxonase-1 activity and gene expression

(2011) G. Ferretti et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Paraoxonase 2 Deficiency Alters Mitochondrial Function and Exacerbates the Development of Atherosclerosis

(2010) Asokan Devarajan et al.   ANTIOXIDANTS & REDOX SIGNALING

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

Antioxidants and glucose metabolism disorders

(2010) Catherine Bisbal et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Human carotid lesion linoleic acid hydroperoxide inhibits paraoxonase 1 (PON1) activity via reaction with PON1 free sulfhydryl cysteine 284

(2010) Hagai Tavori et al.   FREE RADICAL BIOLOGY AND MEDICINE

Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years

(2010) V. W.-S. Wong et al.   GUT

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

(2010) Elizabeth M. Brunt et al.   HEPATOLOGY

Role of protein kinase C in pitavastatin-induced human paraoxonase I expression in Huh7 cells

(2010) Kaoru Arii et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Association of the clusterin gene polymorphisms with type 2 diabetes mellitus

(2010) Makoto Daimon et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Insulin Resistance in Obesity as the Underlying Cause for the Metabolic Syndrome

(2010) Emily J. Gallagher et al.   MOUNT SINAI JOURNAL OF MEDICINE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Paraoxonase-1 Activity in Childhood Obesity and Its Relation to Leptin and Adiponectin Levels

(2010) Péter Koncsos et al.   PEDIATRIC RESEARCH

Increased PAFAH and Oxidized Lipids Are Associated With Inflammation and Atherosclerosis in Hypercholesterolemic Pigs

(2009) Dieuwke De Keyzer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease

(2009) Judit Marsillach et al.   BMC GASTROENTEROLOGY

High-Density Lipoprotein Modulates Glucose Metabolism in Patients With Type 2 Diabetes Mellitus

(2009) Brian G. Drew et al.   CIRCULATION

Involvement of paraoxonase 1 genetic variants in Alzheimer’s disease neuropathology

(2009) Valérie Leduc et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Reconstituted High-Density Lipoprotein Increases Plasma High-Density Lipoprotein Anti-Inflammatory Properties and Cholesterol Efflux Capacity in Patients With Type 2 Diabetes

(2009) Sanjay Patel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Sp1 Phosphorylation and Its Regulation of Gene Transcription

(2009) N. Y. Tan et al.   MOLECULAR AND CELLULAR BIOLOGY

Correlating Cerebral Hypometabolism With Future Memory Decline in Subsequent Converters to Amnestic Pre–Mild Cognitive Impairment

(2008) Richard J. Caselli et al.   ARCHIVES OF NEUROLOGY

Vascular Inflammation, Insulin Resistance, and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance

(2008) Francis Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Glycation of paraoxonase-1 inhibits its activity and impairs the ability of high-density lipoprotein to metabolize membrane lipid hydroperoxides

(2008) M. Mastorikou et al.   DIABETIC MEDICINE

Obesity and Free Fatty Acids

(2008) Guenther Boden   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Relationship of Serum Resistin Level to Traits of Metabolic Syndrome and Serum Paraoxonase 1 Activity in a Population with a Broad Range of Body Mass Index

(2008) L. Bajnok et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Human carotid atherosclerotic plaque increases oxidative state of macrophages and low-density lipoproteins, whereas paraoxonase 1 (PON1) decreases such atherogenic effects

(2008) Hagai Tavori et al.   FREE RADICAL BIOLOGY AND MEDICINE

Serum paraoxonase and arylesterase activities in patients with epithelial ovarian cancer

(2008) Hakan Camuzcuoglu et al.   GYNECOLOGIC ONCOLOGY

Determinants of variation in human serum paraoxonase activity

(2008) D L Rainwater et al.   HEREDITY

High glucose induces transactivation of the human paraoxonase 1 gene in hepatocytes

(2008) Yukio Ikeda et al.   METABOLISM-CLINICAL AND EXPERIMENTAL