Faithful preclinical mouse models for better translation to bedside in the field of immuno-oncology

Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts

(2019) A. Capasso et al.   Journal for ImmunoTherapy of Cancer

A novel immunogenic mouse model of melanoma for the preclinical assessment of combination targeted and immune-based therapy

(2019) Emily J. Lelliott et al.   Scientific Reports

The Cancer Genome Atlas Expression Subtypes Stratify Response to Checkpoint Inhibition in Advanced Urothelial Cancer and Identify a Subset of Patients with High Survival Probability

(2019) Jaegil Kim et al.   EUROPEAN UROLOGY

Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells

(2019) Hongwei Du et al.   CANCER CELL

Personalized Dendritic Cell Vaccines—Recent Breakthroughs and Encouraging Clinical Results

(2019) Beatris Mastelic-Gavillet et al.   Frontiers in Immunology

Molecular Subtype-Specific Immunocompetent Models of High-Grade Urothelial Carcinoma Reveal Differential Neoantigen Expression and Response to Immunotherapy

(2018) Ryoichi Saito et al.   CANCER RESEARCH

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

Mutational landscape of a chemically-induced mouse model of liver cancer

(2018) Frances Connor et al.   JOURNAL OF HEPATOLOGY

Mouse strain and sex as determinants of immune response to trivalent influenza vaccine

(2018) Raisa Petrović et al.   LIFE SCIENCES

Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers

(2018) Daniel P. Hollern et al.   PLoS Genetics

The Use of the Humanized Mouse Model in Gene Therapy and Immunotherapy for HIV and Cancer

(2018) Mayra A. Carrillo et al.   Frontiers in Immunology

Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations

(2018) Jun Gong et al.   Journal for ImmunoTherapy of Cancer

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy

(2018) Atsutaka Minagawa et al.   Cell Stem Cell

Towards the development of human immune-system-on-a-chip platforms

(2018) Alessandro Polini et al.   DRUG DISCOVERY TODAY

Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin

(2018) Simone L. Park et al.   NATURE

Trial watch: The clinical trial landscape for PD1/PDL1 immune checkpoint inhibitors

(2018) Jun Tang et al.   NATURE REVIEWS DRUG DISCOVERY

Impact of Molecular Subtypes in Muscle-invasive Bladder Cancer on Predicting Response and Survival after Neoadjuvant Chemotherapy

(2017) Roland Seiler et al.   EUROPEAN UROLOGY

An Immunogram for the Cancer-Immunity Cycle: Towards Personalized Immunotherapy of Lung Cancer

(2017) Takahiro Karasaki et al.   Journal of Thoracic Oncology

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

(2017) Riccardo Mezzadra et al.   NATURE

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

(2017) Marian L. Burr et al.   NATURE

Patient-derived xenografts as in vivo models for research in urological malignancies

(2017) Takahiro Inoue et al.   Nature Reviews Urology

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Making Mouse Models That Reflect Human Immune Responses

(2017) Lili Tao et al.   TRENDS IN IMMUNOLOGY

Defining the optimal murine models to investigate immune checkpoint blockers and their combination with other immunotherapies

(2016) M. F. Sanmamed et al.   ANNALS OF ONCOLOGY

Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response

(2016) Tiffany A. Reese et al.   Cell Host & Microbe

Molecular Pathways: Breaking the Epithelial Cancer Barrier for Chimeric Antigen Receptor and T-cell Receptor Gene Therapy

(2016) C. S. Hinrichs   CLINICAL CANCER RESEARCH

Antitumor Effect of Programmed Death-1 (PD-1) Blockade in Humanized the NOG-MHC Double Knockout Mouse

(2016) Tadashi Ashizawa et al.   CLINICAL CANCER RESEARCH

Genetically engineered mouse models in oncology research and cancer medicine

(2016) Kelly Kersten et al.   EMBO Molecular Medicine

Does age matter? The impact of rodent age on study outcomes

(2016) Samuel J Jackson et al.   LABORATORY ANIMALS

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

Adapting Cancer Immunotherapy Models for the Real World

(2016) Lauryn E. Klevorn et al.   TRENDS IN IMMUNOLOGY

Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2-/-IL2R null Immunodeficient Mice

(2015) M. F. Sanmamed et al.   CANCER RESEARCH

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

(2015) Sidi Chen et al.   CELL

Preclinical Mouse Cancer Models: A Maze of Opportunities and Challenges

(2015) Chi-Ping Day et al.   CELL

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

Precision cancer mouse models through genome editing with CRISPR-Cas9

(2015) Haiwei Mou et al.   Genome Medicine

Clinical impact of H-Y alloimmunity

(2014) Rakesh Popli et al.   IMMUNOLOGIC RESEARCH

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

(2014) Tobias Bald et al.   NATURE

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system

(2014) Danilo Maddalo et al.   NATURE

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Causes, consequences, and reversal of immune system aging

(2013) Encarnacion Montecino-Rodriguez et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer immunoediting by the innate immune system in the absence of adaptive immunity

(2012) Timothy O’Sullivan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer

(2012) R Saito et al.   ONCOGENE

The evolutionary basis for differences between the immune systems of man, mouse, pig and ruminants

(2012) Mick Bailey et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

A systematic analysis of experimental immunotherapies on tumors differing in size and duration of growth

(2012) Frank T. Wen et al.   OncoImmunology

Natural Innate and Adaptive Immunity to Cancer

(2011) Matthew D. Vesely et al.   Annual Review of Immunology

Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R null humanized mice

(2011) E. Billerbeck et al.   BLOOD

Immunological Variation Between Inbred Laboratory Mouse Strains

(2011) R. S. Sellers et al.   VETERINARY PATHOLOGY

Tumor Immunoediting by NKp46

(2010) M. Elboim et al.   JOURNAL OF IMMUNOLOGY

Systems Biology and Genomics of Breast Cancer

(2010) C. M. Perou et al.   Cold Spring Harbor Perspectives in Biology

Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout Mice

(2009) D. Parra et al.   CANCER RESEARCH

Origin and evolution of the adaptive immune system: genetic events and selective pressures

(2009) Martin F. Flajnik et al.   NATURE REVIEWS GENETICS

Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis

(2008) J. B. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA