Article
Chemistry, Multidisciplinary
Girija Goyal, Pranav Prabhala, Gautam Mahajan, Bruce Bausk, Tal Gilboa, Liangxia Xie, Yunhao Zhai, Roey Lazarovits, Adam Mansour, Min Sun Kim, Aditya Patil, Danielle Curran, Jaclyn M. Long, Sanjay Sharma, Abidemi Junaid, Limor Cohen, Thomas C. Ferrante, Oren Levy, Rachelle Prantil-Baun, David R. Walt, Donald E. Ingber
Summary: In this study, researchers successfully cultured human ectopic lymphoid follicles with similar characteristics to lymphoid follicles in a microfluidic chip. These follicles showed improved immune responses to vaccines and can serve as an alternative to non-human primates for preclinical evaluation.
Article
Immunology
Theinmozhi Arulraj, Sebastian C. Binder, Michael Meyer-Hermann
Summary: The mechanisms of germinal center shutdown are still unclear. This study uses a mathematical model to identify several mechanisms that can promote germinal center contraction and shutdown, including antigen consumption, antigen masking, alterations in cell differentiation and proliferation capacity. In addition, the study proposes experimental methods to further investigate the mechanistic basis of germinal center shutdown.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sang Won Lee, Ji-Yong Moon, Sun-Kyung Lee, Hyun Lee, SeolHwa Moon, Sung Jun Chung, Yoomi Yeo, Tai Sun Park, Dong Won Park, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Sang-Heon Kim
Summary: According to a prospective observational study, factors such as age, sex, obesity, and adverse reactions were not associated with antibody responses after two doses of ChAdOx1 nCoV-19 vaccination.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Stefanie N. N. Meyer, Sanjay Koul, Laura Pasqualucci
Summary: The DNA sequencing revolution has altered our understanding of B-cell lymphomas, with genetically engineered mouse models playing a key role in research. Accurate modeling of genetic alterations found in human GC B cell malignancies can help guide the design of novel therapeutic approaches for this disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Janik Riese, Celine Haehnel, Jonas Menz, Maurice Hannemann, Aydar Khabipov, Felix Luehrs, Tobias Schulze
Summary: The study reveals that S1PR(4) deficiency significantly affects the splenic architecture and germinal center response in abdominal sepsis. In addition, the motility of splenic B cells is reduced in the absence of S1PR(4), but there is only a minor reduction in the titres of specific antibodies produced.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Milou Ohm, Anna G. C. Boef, Susanne P. Stoof, Mariette B. van Ravenhorst, Fiona R. M. van der Klis, Guy A. M. Berbers, Mirjam J. Knol
Summary: The study found that antibody responses were higher in girls than in boys following primary MenAWY vaccination and booster MenC vaccination, although the differences were small and both sexes had high levels of protective antibodies.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Biotechnology & Applied Microbiology
Lucy Denly
Summary: Current evidence does not support the existence of sex differences in the immunogenicity, effectiveness, or efficacy of seasonal influenza vaccines, but females report adverse events following immunization more frequently than males. Further controlled studies are needed to draw conclusions about potential sex differences in response to these vaccines.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Aniket Kini, Rosemary Morgan, Helen Kuo, Patrick Shea, Janna Shapiro, Sean X. Leng, Andrew Pekosz, Sabra L. Klein
Summary: This review examined the impact of sociodemographic variables such as age, sex, race, and gender on influenza vaccine acceptance, coverage, and outcomes. The findings indicate that these factors significantly influence vaccine acceptance rates and outcomes to varying degrees.
Letter
Medicine, General & Internal
Dan P. Ly
Summary: This study examines differences in influenza vaccination rates based on patient race and sex between female and male physicians in the same outpatient setting.
JAMA INTERNAL MEDICINE
(2021)
Article
Immunology
Minjin Kim, Yucheol Cheong, Jinhee Lee, Jongkwan Lim, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: This study demonstrated that caspase-triggered live attenuated influenza vaccine induced broad reactive antibody response and provided heterosubtypic protection against diverse influenza viruses in mice model. The protection relied on non-neutralizing antibodies-mediated ADCC activities and robust mucosal secretion of sIgA, which highlight the potential of this vaccine as a promising option for developing a universal influenza vaccine.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Sulan Zhai, Min Cao, Han Zhou, Huamin Zhu, Tongchang Xu, Yuliang Wang, Xiaoming Wang, Zhenming Cai
Summary: NSD1 plays an important role in regulating the development of B1 and B2 cells, the process of germinal center formation, and high-affinity antibody production. Deletion of NSD1 gene led to a reduction in germinal center response, decreased production of high-affinity antibodies, increased production of low-affinity antibodies, and promoted the development of B1 cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Weijia Xiong, Tim K. Tsang, Ranawaka A. P. M. Perera, Nancy H. L. Leung, Vicky J. Fang, Ian G. Barr, J. S. Malik Peiris, Benjamin J. Cowling
Summary: We explored the biphasic pattern of antibody titers waning after influenza vaccination in children. Using blood samples, we found evidence for a faster waning in the first 1-2 years, followed by a slower decline in the longer term. Children with higher postvaccination titers showed faster antibody decay.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Yo Han Jang, Baik L. Seong
Summary: Influenza virus infection poses a major public health challenge, with current vaccines potentially compromised by viral antigenic changes. Efforts are underway to develop a universal influenza vaccine that provides long-lasting and broad protection. Immune responses induced by live attenuated influenza vaccines (LAIVs), including neutralizing antibodies, T cell responses, and mucosal immunity, show promising potential for serving as attractive platforms for a universal influenza vaccine.
Article
Immunology
Franciane Mouradian Emidio Teixeira, Luana de Mendonca Oliveira, Anna Julia Pietrobon, Erika Machado de Salles, Maria Regina D'Imperio Lima, Isabelle Freire Tabosa Viana, Roberto Dias Lins, Paula Ordonhez Rigato, Ernesto Torres de Azevedo Marques, Alberto Jose da Silva Duarte, Maria Notomi Sato
Summary: Neonatal immunization with a LAMP-1/p55Gag DNA vaccine can enhance antibody production and contribute to the development of new vaccine approaches for other emerging pathogens in early life.
Article
Medicine, General & Internal
Rajeka Lazarus, Sarah Baos, Heike Cappel-Porter, Andrew Carson-Stevens, Madeleine Clout, Lucy Culliford, Stevan R. Emmett, Jonathan Garstang, Lukuman Gbadamoshi, Bassam Hallis, Rosie A. Harris, David Hutton, Nick Jacobsen, Katherine Joyce, Rachel Kaminski, Vincenzo Libri, Alex Middleditch, Liz McCullagh, Ed Moran, Adrian Phillipson, Elizabeth Price, John Ryan, Russell Thirard, Rachel Todd, Matthew D. Snape, David Tucker, Rachel Lauren Williams, Jonathan S. Nguyen-Van-Tam, Adam Finn, Chris A. Rogers
Summary: This study assessed the safety of concomitant administration of COVID-19 and influenza vaccines. The results showed that simultaneous vaccination with ChAdOx1 or BNT162b2 and an age-appropriate influenza vaccine raised no safety concerns and did not adversely affect immune responses.
Article
Sport Sciences
Danica Michalickova, Rajna Minic, Jelena Kotur-Stevuljevic, Marija Andjelkovic, Nenad Dikic, Marija Kostic-Vucicevic, Ondrej Slanar, Brizita Djordjevic
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Olgica Mihaljevic, Snezana Zivancevic-Simonovic, Aleksandra Lucic-Tomic, Irena Zivkovic, Rajna Minic, Ljiljana Mijatovic-Teodorovic, Zorica Jovanovic, Marija Andelkovic, Marijana Stanojevic-Pirkovic
JOURNAL OF MEDICAL BIOCHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Vladimir Milovanovic, Rajna Minic, Jelena Vakic, Sasa Ivanovic, Vitomir Cupic, Suncica Borozan, Andrijana Nesic, Irena Zivkovic
Summary: The study identified LAAO as the enzyme responsible for venom MTT reduction and demonstrated that the monomeric form of LAAO is also active. A new MTT assay method was established for in vitro testing of LAAO activity, with potential applications for testing other snake venoms and antivenoms.
Article
Biochemistry & Molecular Biology
Zorana Lopandic, Luka Dragacevic, Dragan Popovic, Uros Andjelkovic, Rajna Minic, Marija Gavrovic-Jankulovic
Summary: This study designed a BanLec-eGFP chimera for studying the glycosylation structure and function of different microorganisms, successfully expressed and confirmed its structure using molecular modeling and molecular mechanics techniques.
Article
Microbiology
Ana Janjusevic, Ljiljana Markovic Denic, Rajna Minic, Anita Grgurevic, Ivana Cirkovic
Summary: This study investigated VRE intestinal carriage among high-risk inpatients in Serbian university hospitals and characterized the phenotypic/genotypic profiles of the isolated VRE strains. Results showed a high prevalence of VRE carriage and multidrug resistance among the at-risk patients.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Article
Biochemistry & Molecular Biology
Luka Dragacevic, Zorana Lopandic, Marija Gavrovic-Jankulovic, Irena Zivkovic, Veljko Blagojevic, Natalija Polovic, Rajna Minic
Summary: The surface of microorganisms is covered with carbohydrates, making them unique glycan probes. Lectins can bind to these probes, which can be used for selecting microorganisms or novel lectins. The enzyme-linked lectin sorbent assay (ELLSA) is a reliable and convenient method for high-throughput analysis, which can be used for profiling microbial glycan structures or testing novel lectins.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Immunology
Sanja Knezevic, Dejana Kosanovic, Luka Dragacevic, Irena Zivkovic, Vesna Ilic, Ljiljana Hajdukovic, Olivera Savic, Rajna Minic
Summary: This study aimed to explore the differences in levels of S. pneumoniae specific antibodies among different age and gender groups. The results showed that older individuals had lower titres of specific antibodies, especially in men. Men over 50 years of age also had lower antibody levels compared to women under 50 years of age. The study highlights the deficiency in immune response in older individuals, especially males, and suggests immunization with pneumococcal vaccines for this population.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2022)
Article
Medicine, Research & Experimental
Biljana Bufan, Nevena Arsenovic-Ranin, Irena Zivkovic, Raisa Petrovic, Gordana Leposavic
Summary: This study found that chronic propranolol treatment can decrease the antibody response to QIV in mice and the mechanisms may involve cellular and molecular changes. The results of this study are important for understanding the impact of propranolol on immune response.
Article
Immunology
Slavomir Nikodijevic, Veljko Blagojevic, Ivana Curuvija, Dejana Kosanovic, Tamara Djukic, Brizita Djordjevic, Vesna Ilic, Rajna Minic
Summary: Increased interest in microbiota has led to the need for thorough analysis of antibody reactivity to different microorganisms. This study investigated the binding and specificity of salivary IgA, a key component of the immune defense against microorganisms, to various microorganisms. The results showed that this analysis method can differentiate species/strains with high IgA binding capacity and should be further confirmed on a larger sample size. Additionally, comparisons were made between the binding of salivary IgA and serum IgA in response to whole microbial cells and purified microbial components, revealing higher specificity in the serum IgA repertoire. The study concludes that the composition of the steady state salivary IgA repertoire raises questions about its ability to select resident microbiota.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Infectious Diseases
Ana Janjusevic, Ivana Cirkovic, Rajna Minic, Goran Stevanovic, Ivan Soldatovic, Biljana Mihaljevic, Ana Vidovic, Ljiljana Markovic Denic
Summary: This study aimed to identify risk factors associated with fecal VRE colonization among high-risk inpatients in university hospitals in Serbia. The results showed that age ≥65 years, stay in geriatric, ICU, or haemato-oncology departments, and the use of cephalosporins and fluoroquinolones increased the risk for VRE colonization.
Article
Biochemistry & Molecular Biology
Rajna Minic, Aleksandra Arsic, Milica Kojadinovic, Aleksa Palibrk, Brizita Djordjevic, Zorica Stevic
Summary: The study identified significant differences in fatty acid composition in erythrocytes of ALS patients compared to healthy volunteers, suggesting metabolic disturbances in ALS. There were correlations between fatty acid levels and ALS disease assessment scores, as well as disease duration, providing important insights for potential interventions.
JOURNAL OF MEDICAL BIOCHEMISTRY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Z. Lopandic, D. Kosanovic, L. Dragacevic, L. Burazer, M. Gavrovic-Jankulovic, R. Minic
Article
Pharmacology & Pharmacy
O. Zuza, R. Minic, J. Kotur-Stevuljevic, D. Zujovic, B. Dordevic, A. Ilic
Summary: This study compared the effects of N-acetyl cysteine (NAC) alone and NAC in combination with propolis (NACP) on oxidative stress and inflammation parameters in COPD patients. The results showed that NACP treatment was more successful in reducing oxidative stress and inflammation compared to NAC treatment.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.