BAFF inhibition in SLE-Is tolerance restored?

Current challenges in the development of new treatments for lupus

(2019) Maria Dall'Era et al.   ANNALS OF THE RHEUMATIC DISEASES

Organ damage in patients treated with belimumab versus standard of care: a propensity score-matched comparative analysis

(2019) Murray B Urowitz et al.   ANNALS OF THE RHEUMATIC DISEASES

Phase III, multicentre, randomised, double-blind, placebo-controlled, 104-week study of subcutaneous belimumab administered in combination with rituximab in adults with systemic lupus erythematosus (SLE): BLISS-BELIEVE study protocol

(2019) Y K Onno Teng et al.   BMJ Open

Linking signaling and selection in the germinal center

(2019) Mark J. Shlomchik et al.   IMMUNOLOGICAL REVIEWS

Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches

(2019) Ann M. Haberman et al.   IMMUNOLOGICAL REVIEWS

Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma

(2019) Noopur Raje et al.   NEW ENGLAND JOURNAL OF MEDICINE

BAFF and CD4+T cells are major survival factors for long-lived splenic plasma cells in a B-cell–depletion context

(2018) Lan-Huong Thai et al.   BLOOD

BAFF Neutralization Aggravates Atherosclerosis

(2018) Dimitrios Tsiantoulas et al.   CIRCULATION

TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis

(2018) Lunhua Liu et al.   DIABETES

B-cell activating factor and related genetic variants in lupus related atherosclerosis

(2018) Evangelos Theodorou et al.   JOURNAL OF AUTOIMMUNITY

Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity

(2018) Debra D. Bloom et al.   JOURNAL OF IMMUNOTHERAPY

TACI deletion protects against progressive murine lupus nephritis induced by BAFF overexpression

(2018) Tanvi Arkatkar et al.   KIDNEY INTERNATIONAL

Systematic review, and meta-analysis of steroid-sparing effect, of biologic agents in randomized, placebo-controlled phase 3 trials for systemic lupus erythematosus

(2018) Shereen Oon et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors

(2018) Michele Vigolo et al.   Nature Communications

BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus

(2018) Woori Shin et al.   Nature Communications

Efficacy and Safety of Atacicept in Patients With Systemic Lupus Erythematosus

(2018) Joan T. Merrill et al.   Arthritis & Rheumatology

Long-Term Safety and Efficacy of Belimumab in Patients With Systemic Lupus Erythematosus

(2018) Richard A. Furie et al.   Arthritis & Rheumatology

BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance

(2018) Takashi Matsushita et al.   Science Advances

Shedding of BAFF/APRIL Receptors Controls B Cells

(2018) Edgar Meinl et al.   TRENDS IN IMMUNOLOGY

Combined immunosuppressive treatment (CIST) in lupus nephritis: a multicenter, randomized controlled study

(2018) Yuan An et al.   CLINICAL RHEUMATOLOGY

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

The role of APRIL - A proliferation inducing ligand - In autoimmune diseases and expectations from its targeting

(2018) Laurie Baert et al.   JOURNAL OF AUTOIMMUNITY

TACI Isoforms Regulate Ligand Binding and Receptor Function

(2018) Yolanda Garcia-Carmona et al.   Frontiers in Immunology

BAFF and BAFF-Receptor in B Cell Selection and Survival

(2018) Cristian R. Smulski et al.   Frontiers in Immunology

Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab

(2018) Christine Kowalczyk-Quintas et al.   Frontiers in Immunology

A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens

(2017) Vishal J. Sindhava et al.   JOURNAL OF CLINICAL INVESTIGATION

Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy

(2017) Qiming Wang et al.   JOURNAL OF IMMUNOLOGY

B cell activating factor (BAFF) selects IL-10 − B cells over IL-10 + B cells during inflammatory responses

(2017) Ning Ma et al.   MOLECULAR IMMUNOLOGY

Overexpression of the Cytokine BAFF and Autoimmunity Risk

(2017) Maristella Steri et al.   NEW ENGLAND JOURNAL OF MEDICINE

mTOR intersects antibody-inducing signals from TACI in marginal zone B cells

(2017) Jordi Sintes et al.   Nature Communications

BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells

(2017) Cristian R. Smulski et al.   Cell Reports

Gene Expression and Pharmacodynamic Changes in 1,760 Systemic Lupus Erythematosus Patients From Two Phase III Trials of BAFF Blockade With Tabalumab

(2017) Robert W. Hoffman et al.   Arthritis & Rheumatology

Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells

(2017) Padmapriya Ponnuswamy et al.   Scientific Reports

Germinal centers and autoimmune disease in humans and mice

(2016) Anthony L DeFranco   IMMUNOLOGY AND CELL BIOLOGY

The Regulation of Inherently Autoreactive VH4-34–Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa

(2016) Geoffrey T. Hart et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation

(2016) Shaun W. Jackson et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells

(2016) Holly M. Jacobs et al.   JOURNAL OF IMMUNOLOGY

The Effect of BAFF Inhibition on Autoreactive B-Cell Selection in Murine Systemic Lupus Erythematosus

(2016) Alexis Boneparth et al.   MOLECULAR MEDICINE

Checkpoints for Autoreactive B Cells in the Peripheral Blood of Lupus Patients Assessed by Flow Cytometry

(2016) Susan Malkiel et al.   Arthritis & Rheumatology

CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk

(2015) E. Hobeika et al.   EMBO JOURNAL

BAFF-driven autoimmunity requires CD19 expression

(2015) Kirsten A. Fairfax et al.   JOURNAL OF AUTOIMMUNITY

Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers

(2015) William A. Figgett et al.   JOURNAL OF AUTOIMMUNITY

ATON: Results from a Phase II randomized trial of the B-cell-targeting agent atacicept in patients with optic neuritis

(2015) Robert C. Sergott et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus

(2015) Christopher M Tipton et al.   NATURE IMMUNOLOGY

TACI deficiency leads to alternatively activated macrophage phenotype and susceptibility toLeishmaniainfection

(2015) Windy R. Allman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

γ-secretase directly sheds the survival receptor BCMA from plasma cells

(2015) Sarah A. Laurent et al.   Nature Communications

Differential Development of Systemic Lupus Erythematosus in NZM 2328 Mice Deficient in Discrete Pairs of BAFF Receptors

(2015) Chaim O. Jacob et al.   Arthritis & Rheumatology

Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL

(2014) M. J. Benson et al.   JOURNAL OF IMMUNOLOGY

The Immunoregulator Soluble TACI Is Released by ADAM10 and Reflects B Cell Activation in Autoimmunity

(2014) Franziska S. Hoffmann et al.   JOURNAL OF IMMUNOLOGY

Effects ofAPRIL(TNFSF13) polymorphisms and splicing isoforms on the secretion of soluble APRIL

(2014) Takumi Furuya et al.   Modern Rheumatology

A Pathway Switch Directs BAFF Signaling to Distinct NFκB Transcription Factors in Maturing and Proliferating B Cells

(2014) Jonathan V. Almaden et al.   Cell Reports

Identification of Stage-Specific Genes Associated With Lupus Nephritis and Response to Remission Induction in (NZB × NZW)F1 and NZM2410 Mice

(2014) Ramalingam Bethunaickan et al.   Arthritis & Rheumatology

Non-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures

(2014) Sandra Gardam et al.   Frontiers in Immunology

Development of Systemic Lupus Erythematosus in NZM 2328 Mice in the Absence of any Single BAFF Receptor

(2013) Chaim O. Jacob et al.   ARTHRITIS AND RHEUMATISM

Regulatory Roles of the Tumor Necrosis Factor Receptor BCMA

(2013) Christine M. Coquery et al.   CRITICAL REVIEWS IN IMMUNOLOGY

The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway

(2013) Edina Schweighoffer et al.   IMMUNITY

Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation

(2013) Radhika Goenka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comparative Transcriptional Profiling of 3 Murine Models of SLE Nephritis Reveals Both Unique and Shared Regulatory Networks

(2013) Ramalingam Bethunaickan et al.   PLoS One

Context-Specific BAFF-R Signaling by the NF-κB and PI3K Pathways

(2013) Julia Jellusova et al.   Cell Reports

Belimumab in the treatment of systemic lupus erythematosus: high disease activity predictors of response

(2012) Ronald F van Vollenhoven et al.   ANNALS OF THE RHEUMATIC DISEASES

Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival

(2012) Xue Q. Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Yaa Locus and IFN-α Fine-Tune Germinal Center B Cell Selection in Murine Systemic Lupus Erythematosus

(2012) Ioana Moisini et al.   JOURNAL OF IMMUNOLOGY

Selective APRIL Blockade Delays Systemic Lupus Erythematosus in Mouse

(2012) Bertrand Huard et al.   PLoS One

Atacicept in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor antagonist therapy: Results of a phase II, randomized, placebo-controlled, dose-finding trial

(2011) M. C. Genovese et al.   ARTHRITIS AND RHEUMATISM

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

(2011) Richard Furie et al.   ARTHRITIS AND RHEUMATISM

Dispensability of APRIL to the development of systemic lupus erythematosus in NZM 2328 mice

(2011) Chaim O. Jacob et al.   ARTHRITIS AND RHEUMATISM

TACI deficiency impairs sustained Blimp-1 expression in B cells decreasing long-lived plasma cells in the bone marrow

(2011) S. Tsuji et al.   BLOOD

BAFF-R expression correlates with positive selection of immature B cells

(2011) Roxane Tussiwand et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Development of autoimmune nephritis in genetically asplenic and splenectomized BAFF transgenic mice

(2011) Carrie A. Fletcher et al.   JOURNAL OF AUTOIMMUNITY

B Cell Maturation Antigen Deficiency Exacerbates Lymphoproliferation and Autoimmunity in Murine Lupus

(2011) C. Jiang et al.   JOURNAL OF IMMUNOLOGY

BAFF/APRIL Inhibition Decreases Selection of Naive but Not Antigen-Induced Autoreactive B Cells in Murine Systemic Lupus Erythematosus

(2011) W. Huang et al.   JOURNAL OF IMMUNOLOGY

Cellular Competition Independent of BAFF/B Lymphocyte Stimulator Results in Low Frequency of an Autoreactive Clonotype in Mature Polyclonal B Cell Compartments

(2011) N. Nikbakht et al.   JOURNAL OF IMMUNOLOGY

IFN-  Confers Resistance of Systemic Lupus Erythematosus Nephritis to Therapy in NZB/W F1 Mice

(2011) Z. Liu et al.   JOURNAL OF IMMUNOLOGY

B Cell and BAFF Dependence of IFN- -Exaggerated Disease in Systemic Lupus Erythematosus-Prone NZM 2328 Mice

(2011) N. Jacob et al.   JOURNAL OF IMMUNOLOGY

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Selective blockade of BAFF for the prevention and treatment of systemic lupus erythematosus nephritis in NZM2410 mice

(2010) Meera Ramanujam et al.   ARTHRITIS AND RHEUMATISM

B-cell stage and context-dependent requirements for survival signals from BAFF and the B-cell receptor

(2010) Fabienne Mackay et al.   IMMUNOLOGICAL REVIEWS

BAFF Receptor Signaling Aids the Differentiation of Immature B Cells into Transitional B Cells following Tonic BCR Signaling

(2010) S. L. Rowland et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Novel Function of B Cell-Activating Factor in the Induction of IL-10-Producing Regulatory B Cells

(2010) M. Yang et al.   JOURNAL OF IMMUNOLOGY

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

(2010) Bing He et al.   NATURE IMMUNOLOGY

Mouse Models of Systemic Lupus Erythematosus Reveal a Complex Pathogenesis

(2010) J. B. Rottman et al.   VETERINARY PATHOLOGY

Prevention of murine antiphospholipid syndrome by BAFF blockade

(2008) Philip Kahn et al.   ARTHRITIS AND RHEUMATISM

TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties

(2008) Fabienne Mackay et al.   CYTOKINE & GROWTH FACTOR REVIEWS

B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta

(2008) Thomas Henley et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling

(2008) Jason E Stadanlick et al.   NATURE IMMUNOLOGY

Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis

(2008) Q. Lai Kwan Lam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact

(2008) J. L. Scholz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of new splice variants of the genes BAFF and BCMA

(2007) Anna S. Smirnova et al.   MOLECULAR IMMUNOLOGY